Protein engineering; Antibody engineering; Protein design and directed evolution; Protein biochemistry; Structural biology; Fluorescent biosensors; Optogenetics; Genome Engineering; Cell signaling; Post-translational modification; Cancer biology.
Zhou, X., Zou, X., Lin, M. 2017. A single-chain photoswitchable Cas9 architecture for inducible gene editing and transcription. ACS Chemical Biology. In Press. 2017.
Zhou, X., Fan, L., Li, P., Shen, K., Lin, M. 2017. Optical Control of Cell Signaling by Single-chain Photoswitchable Kinases. Science. 355: 836 – 842.
Bajar, B., Lam, A., Radiee, R., Oh, Y., Chu, J., Zhou, X., Kim, N., Kim, B., Chung, M., Yablonovitch, A., Cruz, B., Kulalert, K., Tao, J., Meyer, T., Su, X., Lin, M. 2016. Fluorescent indicators for simultaneous reporting of all four cell cycle phases. Nature Methods. 13: 993 – 996.
Zhou, X., Pan, M., Lin, M. 2015. Investigating neuronal function with optically controllable proteins. 2015. Frontiers in Molecular Neuroscience. 8: 37.
Zhou X., Lin M. 2015. Experimental systems for optogenetic control of protein activity with photodissociable fluorescent proteins. Proc. SPIE 9305, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II, 930534.
Zhou, X., Lin, M. 2013. Photoswitchable fluorescent proteins: ten years of colorful chemistry and exciting applications. Curr. Opin. Chem. Biol. 17: 682 – 690.
Zhou, X., Chung, H., Lam, A., Lin, M. 2012. Optical control of protein activity by fluorescent protein domains. Science 338: 810 – 814.