Education
PhD, National Institute of Mental Health and Neurosciences (NIMHANS), India, 2012
Lab information
Dr Piera Pasinelli lab, Jefferson Weinberg ALS Center
http://www.jefferson.edu/university/farber_institute/weinberg_als_center.html
Research focus
Cell Biology, Neuronal cultures, live cell imaging, calcium signaling, microscopy, stress granules, Neurodegeneration, ALS, neuromuscular junction, synaptic dysfunction,
Publications
https://scholar.google.com/citations?user=rx8auDgAAAAJ&hl=en&authuser=21. Casci I, Krishnamurthy K*, Kour S, Tripathy V, Ramesh N, Anderson EN, Marrone L,
Grant RA, Oliver S, Gochenaur L, Patel K, Sterneckert J, Gleixner AM, Donnelly
CJ, Ruepp MD, Sini AM, Zuccaro E, Pennuto M, Pasinelli P, Pandey UB. Muscleblind
acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN
localization. Nat Commun. 2019 Dec 6;10(1):5583. doi: 10.1038/s41467-019-13383-z.
PubMed [citation] PMID: 31811140, PMCID: PMC6898697
2. Charsar BA, Brinton MA, Locke K, Chen AY, Ghosh B, Urban MW, Komaravolu S,
Krishnamurthy K, Smit R, Pasinelli P, Wright MC, Smith GM, Lepore AC. AAV2-BDNF
promotes respiratory axon plasticity and recovery of diaphragm function following
spinal cord injury. FASEB J. 2019 Dec;33(12):13775-13793. doi:
10.1096/fj.201901730R. Epub 2019 Oct 2. PubMed [citation] PMID: 31577916, PMCID:
PMC6894085
3. Kia A, McAvoy K, Krishnamurthy K, Trotti D, Pasinelli P. Astrocytes expressing
ALS-linked mutant FUS induce motor neuron death through release of tumor necrosis
factor-alpha. Glia. 2018 May;66(5):1016-1033. doi: 10.1002/glia.23298. Epub 2018
Jan 30. PubMed [citation] PMID: 29380416, PMCID: PMC5873384
4. Daigle JG, Krishnamurthy K*, Ramesh N, Casci I, Monaghan J, McAvoy K, Godfrey EW,
Daniel DC, Johnson EM, Monahan Z, Shewmaker F, Pasinelli P, Pandey UB. Pur-alpha
regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity. Acta
Neuropathol. 2016 Apr;131(4):605-20. doi: 10.1007/s00401-015-1530-0. Epub 2016
Jan 4. PubMed [citation] PMID: 26728149, PMCID: PMC4791193
5. Wen X, Tan W, Westergard T, Krishnamurthy K, Markandaiah SS, Shi Y, Lin S,
Shneider NA, Monaghan J, Pandey UB, Pasinelli P, Ichida JK, Trotti D. Antisense
proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear
aggregates that initiate in vitro and in vivo neuronal death. Neuron. 2014 Dec
17;84(6):1213-25. doi: 10.1016/j.neuron.2014.12.010. PubMed [citation] PMID:
25521377, PMCID: PMC4632245
6. Krishnamurthy K, Mehta B, Singh M, Tewari BP, Joshi PG, Joshi NB.
Depalmitoylation preferentially downregulates AMPA induced Ca2+ signaling and
neurotoxicity in motor neurons. Brain Res. 2013 Sep 5;1529:143-53. doi:
10.1016/j.brainres.2013.06.039. Epub 2013 Jul 10. PubMed [citation] PMID:
23850769
7. Joshi DC, Singh M, Krishnamurthy K, Joshi PG, Joshi NB. AMPA induced Ca2+ influx
in motor neurons occurs through voltage gated Ca2+ channel and Ca2+ permeable
AMPA receptor. Neurochem Int. 2011 Nov;59(6):913-21. doi:
10.1016/j.neuint.2011.06.023. Epub 2011 Jul 13. PubMed [citation] PMID: 21777635