Huei San Leong The Walter and Eliza Hall Institute of Medical Research
1 protocol

Marnie Blewitt
  • Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Australia
Research focus
  • Cancer biology
  • 1 Author merit


Ph.D. in Mammalian Epigenetics, Department of Molecular and Microbial Biosciences, University of Sydney, Australia, 2004

Current position

Laboratory head and faculty member, Molecular Medicine Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia

Publications (since 2005)

Primary publications

  1. Mould, A. W., Pang, Z., Pakusch, M., Tonks, I. D., Stark, M., Carrie, D., Mukhopadhyay, P., Seidel, A., Ellis, J. J., Deakin, J., Wakefield, M. J., Krause, L., Blewitt, M. E. and Kay, G. F. (2013). Smchd1 regulates a subset of autosomal genes subject to monoallelic expression in addition to being critical for X inactivation. Epigenetics Chromatin 6(1): 19.
  2. Leong, H. S., Chen, K., Hu, Y., Lee, S., Corbin, J., Pakusch, M., Murphy, J. M., Majewski, I. J., Smyth, G. K., Alexander, W. S., Hilton, D. J. and Blewitt, M. E. (2013). Epigenetic regulator Smchd1 functions as a tumor suppressor. Cancer Res 73(5): 1591-1599.
  3. Lewis, R. S., Kolesnik, T. B., Kuang, Z., D'Cruz, A. A., Blewitt, M. E., Masters, S. L., Low, A., Willson, T., Norton, R. S. and Nicholson, S. E. (2011). TLR regulation of SPSB1 controls inducible nitric oxide synthase induction. J Immunol 187(7): 3798-3805.
  4. Young, M. D., Willson, T. A., Wakefield, M. J., Trounson, E., Hilton, D. J., Blewitt, M. E., Oshlack, A. and Majewski, I. J. (2011). ChIP-seq analysis reveals distinct H3K27me3 profiles that correlate with transcriptional activity. Nucleic Acids Res 39(17): 7415-7427.
  5. Roberts, A. R., Blewitt, M. E., Youngson, N. A., Whitelaw, E. and Chong, S. (2011). Reduced dosage of the modifiers of epigenetic reprogramming Dnmt1, Dnmt3L, SmcHD1 and Foxo3a has no detectable effect on mouse telomere length in vivo. Chromosoma 120(4): 377-385.
  6. Majewski, I. J., Ritchie, M. E., Phipson, B., Corbin, J., Pakusch, M., Ebert, A., Busslinger, M., Koseki, H., Hu, Y., Smyth, G. K., Alexander, W. S., Hilton, D. J. and Blewitt, M. E. (2010). Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells. Blood 116(5): 731-739.
  7. Ashe, A., Morgan, D. K., Whitelaw, N. C., Bruxner, T. J., Vickaryous, N. K., Cox, L. L., Butterfield, N. C., Wicking, C., Blewitt, M. E., Wilkins, S. J., Anderson, G. J., Cox, T. C. and Whitelaw, E. (2008). A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development. Genome Biol 9(12): R182.
  8. Blewitt, M. E., Gendrel, A. V., Pang, Z., Sparrow, D. B., Whitelaw, N., Craig, J. M., Apedaile, A., Hilton, D. J., Dunwoodie, S. L., Brockdorff, N., Kay, G. F. and Whitelaw, E. (2008). SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation. Nat Genet 40(5): 663-669.
  9. Majewski, I. J., Blewitt, M. E., de Graaf, C. A., McManus, E. J., Bahlo, M., Hilton, A. A., Hyland, C. D., Smyth, G. K., Corbin, J. E., Metcalf, D., Alexander, W. S. and Hilton, D. J. (2008). Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity. PLoS Biol 6(4): e93.
  10. Chong, S., Vickaryous, N., Ashe, A., Zamudio, N., Youngson, N., Hemley, S., Stopka, T., Skoultchi, A., Matthews, J., Scott, H. S., de Kretser, D., O'Bryan, M., Blewitt, M. and Whitelaw, E. (2007). Modifiers of epigenetic reprogramming show paternal effects in the mouse. Nat Genet 39(5): 614-622.
  11. Blewitt, M. E., Vickaryous, N. K., Paldi, A., Koseki, H. and Whitelaw, E. (2006). Dynamic reprogramming of DNA methylation at an epigenetically sensitive allele in mice. PLoS Genet 2(4): e49.
  12. Blewitt, M. E., Vickaryous, N. K., Hemley, S. J., Ashe, A., Bruxner, T. J., Preis, J. I., Arkell, R. and Whitelaw, E. (2005). An N-ethyl-N-nitrosourea screen for genes involved in variegation in the mouse. Proc Natl Acad Sci U S A 102(21): 7629-7634.

Book chapters

  1. Blewitt ME and Whitelaw E – for 2012 publication. Mouse models in epigenetics research, in Epigenetics – 2nd Edition. Publisher: Cold Spring Harbour Laboratories. Editors: Danny Reinberg, Thomas Jenuwein and C David Allis
  2. Gearing LJ and Blewitt ME (Sept 2011) Mammalian X inactivation, In; Epigenetics: A Reference Manual, Publisher: Caister Academic Press, Editors Jeffrey M Craig and Nicholas C Wong
1 Protocol published
Retrovirus Mediated Malignant Transformation of Mouse Embryonic Fibroblasts
Authors:  Huei San Leong and Marnie Blewitt, date: 08/05/2013, view: 10523, Q&A: 2
Cellular transformation is a widely used method to artificially induce cells to form tumours in vivo. Here, we describe the methodology for malignant transformation of mouse embryonic fibroblasts (MEFs) for transplantation into ...
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