Jianzhu Chen The Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology (MIT), USA
2 protocols

Qingfeng Chen
  • Humanized Mouse Unit, Institute of Molecular and Cell Biology, Singapore
Research focus
  • Stem cell
  • 2 Author merit


Ph.D. in Cellular and Molecular Immunology, University of Science and Technology of China

Current Position

Head, Humanized mouse unit, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore


  1. Sridharan, A., Chen, Q., Tang, K. F., Ooi, E. E., Hibberd, M. L. and Chen, J. (2013). Inhibition of megakaryocyte development in the bone marrow underlies dengue virus-induced thrombocytopenia in humanized mice. J Virol 87(21): 11648-11658. (IF=5.076)
  2. Li, Y.*, Chen, Q.*, Zheng, D., Yin, L., Chionh, Y. H., Wong, L. H., Tan, S. Q., Tan, T. C., Chan, J. K., Alonso, S., Dedon, P. C., Lim, B. and Chen, J. (2013). Induction of functional human macrophages from bone marrow promonocytes by M-CSF in humanized mice. J Immunol 191(6): 3192-3199. (IF=5.520)
  3. Chen, Q., Khoury, M., Limmon, G., Choolani, M., Chan, J. K. and Chen, J. (2013). Human fetal hepatic progenitor cells are distinct from, but closely related to, hematopoietic stem/progenitor cells. Stem Cells 31(6): 1160-1169. (IF=7.9)
  4. He, F., Kiener, T. K., Lim, X. F., Tan, Y., Raj, K. V., Tang, M., Chow, V. T., Chen, Q. and Kwang, J. (2013). Development of a sensitive and specific epitope-blocking ELISA for universal detection of antibodies to human enterovirus 71 strains. PLoS One 8(1): e55517. (IF=3.730)
  5. Chen, Q., He, F., Kwang, J., Chan, J. K. and Chen, J. (2012). GM-CSF and IL-4 stimulate antibody responses in humanized mice by promoting T, B, and dendritic cell maturation. J Immunol 189(11): 5223-5229. (IF=5.520)
  6. Drake, A.* C., Chen*, Q. and Chen, J. (2012). Engineering humanized mice for improved hematopoietic reconstitution. Cell Mol Immunol 9(3): 215-224. (IF= 3.419)
  7. Khoury, M., Drake, A., Chen, Q., Dong, D., Leskov, I., Fragoso, M. F., Li, Y., Iliopoulou, B. P., Hwang, W., Lodish, H. F. and Chen, J. (2011). Mesenchymal stem cells secreting angiopoietin-like-5 support efficient expansion of human hematopoietic stem cells without compromising their repopulating potential. Stem Cells Dev 20(8): 1371-1381. (IF= 4.670)
  8. Chen, Q., Khoury, M. and Chen, J. (2009). Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice. Proc Natl Acad Sci U S A 106(51): 21783-21788. (IF=9.737)
  9. Chen, Q., Wei, H., Sun, R., Zhang, J. and Tian, Z. (2008). Therapeutic RNA silencing of Cys-X3-Cys chemokine ligand 1 gene prevents mice from adenovirus vector-induced acute liver injury. Hepatology 47(2): 648-658. (IF=12.003)
  10. Ren, T.*, Chen, Q.*, Tian, Z. and Wei, H. (2007). Down-regulation of surface fractalkine by RNA interference in B16 melanoma reduced tumor growth in mice. Biochem Biophys Res Commun 364(4): 978-984. (IF=2.500)
  11. Zhang, X., Wei, H., Chen, Q. and Tian, Z. (2007). Activation of human natural killer cells by recombinant membrane-expressed fractalkine on the surface of tumor cells. Oncol Rep 17(6): 1371-1375. (IF= 2.297)

    * Co-first author
2 Protocols published
Serial Transfer of Human Hematopoietic and Hepatic Stem/progenitor Cells
Authors:  Qingfeng Chen and Jianzhu Chen, date: 12/05/2013, view: 12914, Q&A: 0
A range of assays have been developed to determine the stemness or stem cell activity of human stem cells. The key assays of stem cells are functional: they must show self-renewal and the ability to generate the appropriate tissue. The best assays ...
Isolation of CD34+ Cells from Human Fetal Liver and Cord Blood
Authors:  Qingfeng Chen and Jianzhu Chen, date: 12/05/2013, view: 12185, Q&A: 6
CD34 is a glycosylated cell surface protein and represents a well-known marker for primitive progenitor cells in various organs, especially cord blood, bone marrow and fetal liver. CD34+ progenitor cells are suitable for a series of ...
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