Henrich Cheng Neural Regeneration Laboratory, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taiwan
1 protocol

Chuan-Wen Chiu Genomics Research Center, Academia Sinica, Taiwan
1 protocol

Szu-Ting Chen National Yang-Ming University
1 protocol

Shie-Liang Edmond Hsieh
  • Genomics Research Center, Academia Sinica, Taiwan
Research focus
  • Immunology
  • 2 Author merit


MD in School of Medicine, National Yang-Ming University, Taipei, Taiwan, 1984
D.Phil. in the Department of Biochemistry, University of Oxford, 1992

Current position

Director, Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan

Publications (Since 2005)

  1. Chen, S. T., Liu, R. S., Wu, M. F., Lin, Y. L., Chen, S. Y., Tan, D. T., Chou, T. Y., Tsai, I. S., Li, L. and Hsieh, S. L.* (2012). CLEC5A regulates Japanese encephalitis virus-induced neuroinflammation and lethality. PLoS Pathog 8(4): e1002655.
  2. Tai, S. K., Chang, H. C., Lan, K. L., Lee, C. T., Yang, C. Y., Chen, N. J., Chou, T. Y., Tarng, D. C. and Hsieh, S. L.* (2012). Decoy receptor 3 enhances tumor progression via induction of tumor-associated macrophages. J Immunol 188(5): 2464-2471.
  3. Kuo, S. C., Lee, Y. T., Yang, S. P., Chen, C. P., Chen, T. L., Hsieh, S. L., Siu, L. K. and Fung, C. P. (2012). Eradication of multidrug-resistant Acinetobacter baumannii from the respiratory tract with inhaled colistin methanesulfonate: a matched case-control study. Clin Microbiol Infect 18(9): 870-876.
  4. Hwang, S. J., Chang, S. C., Yu, C. J., Chan, Y. J., Chen, T. J., Hsieh, S. L., Lai, H. Y., Lin, M. H., Liu, J. Y., Ong, G., Roman, F., Drame, M., Bock, H. L. and Yang, P. C. (2011). Immunogenicity and safety of an AS03(A)-adjuvanted H5N1 influenza vaccine in a Taiwanese population. J Formos Med Assoc 110(12): 780-786.
  5. Lin, W. W. and Hsieh, S. L.* (2011). Decoy receptor 3: a pleiotropic immunomodulator and biomarker for inflammatory diseases, autoimmune diseases and cancer. Biochem Pharmacol 81(7): 838-847.
  6. Tai, S. K., Yang, M. H., Chang, S. Y., Chang, Y. C., Li, W. Y., Tsai, T. L., Wang, Y. F., Chu, P. Y. and Hsieh, S. L.* (2011). Persistent Kruppel-like factor 4 expression predicts progression and poor prognosis of head and neck squamous cell carcinoma. Cancer Sci 102(4): 895-902.
  7. Lee, R. T., Hsu, T. L., Huang, S. K., Hsieh, S. L., Wong, C. H. and Lee, Y. C. (2011). Survey of immune-related, mannose/fucose-binding C-type lectin receptors reveals widely divergent sugar-binding specificities. Glycobiology 21(4): 512-520.
  8. Kuo, W. C., Yang, K. T., Hsieh, S. L. and Lai, M. Z. (2010). Ezrin is a negative regulator of death receptor-induced apoptosis. Oncogene 29(9): 1374-1383.
  9. Liu, P. F., Shi, W., Zhu, W., Smith, J. W., Hsieh, S. L., Gallo, R. L. and Huang, C. M. (2010). Vaccination targeting surface FomA of Fusobacterium nucleatum against bacterial co-aggregation: Implication for treatment of periodontal infection and halitosis. Vaccine 28(19): 3496-3505.
  10. Hsu, T. L., Cheng, S. C., Yang, W. B., Chin, S. W., Chen, B. H., Huang, M. T., Hsieh, S. L.** and Wong, C. H.** (2009). Profiling carbohydrate-receptor interaction with recombinant innate immunity receptor-Fc fusion proteins. J Biol Chem 284(50): 34479-34489.
  11. Wu, M. F., Yang, C. Y., Lin, T. L., Wang, J. T., Yang, F. L., Wu, S. H., Hu, B. S., Chou, T. Y., Tsai, M. D., Lin, C. H. and Hsieh, S. L.* (2009). Humoral immunity against capsule polysaccharide protects the host from magA+ Klebsiella pneumoniae-induced lethal disease by evading Toll-like receptor 4 signaling. Infect Immun 77(2): 615-621.
  12. Chen, C. Y., Yang, K. Y., Chen, M. Y., Chen, H. Y., Lin, M. T., Lee, Y. C., Perng, R. P., Hsieh, S. L., Yang, P. C. and Chou, T. Y. (2009). Decoy receptor 3 levels in peripheral blood predict outcomes of acute respiratory distress syndrome. Am J Respir Crit Care Med 180(8): 751-760.
  13. Chao, W.-W., Kuo, Y.-H., Hsieh, S.-L. and Lin, B.-F. (2011). Inhibitory effects of ethyl acetate extract of Andrographis paniculata on NF-κB trans-activation activity and LPS-induced acute inflammation in mice. Evidence-Based Complementary and Alternative Medicine 2011.
  14. Hsieh, S.L.*, Decoy Receptor 3 (DcR3): A Pleiotropic Immunomodulator. Blood, 112, 916-917.
  15. Chen, S. T., Lin, Y. L., Huang, M. T., Wu, M. F., Cheng, S. C., Lei, H. Y., Lee, C. K., Chiou, T. W., Wong, C. H. and Hsieh, S. L.* (2008). CLEC5A is critical for dengue-virus-induced lethal disease. Nature 453(7195): 672-676.
  16. Chang, Y. C., Chen, T. C., Lee, C. T., Yang, C. Y., Wang, H. W., Wang, C. C. and Hsieh, S. L.* (2008). Epigenetic control of MHC class II expression in tumor-associated macrophages by decoy receptor 3. Blood 111(10): 5054-5063.
  17. You, R. I., Chang, Y. C., Chen, P. M., Wang, W. S., Hsu, T. L., Yang, C. Y., Lee, C. T. and Hsieh, S. L.* (2008). Apoptosis of dendritic cells induced by decoy receptor 3 (DcR3). Blood 111(3): 1480-1488.
  18. Lee, C. S., Hu, C. Y., Tsai, H. F., Wu, C. S., Hsieh, S. L., Liu, L. C. and Hsu, P. N. (2008). Elevated serum decoy receptor 3 with enhanced T cell activation in systemic lupus erythematosus. Clin Exp Immunol 151(3): 383-390.
  19. Wang, S. K., Liang, P. H., Astronomo, R. D., Hsu, T. L., Hsieh, S. L., Burton, D. R. and Wong, C. H. (2008). Targeting the carbohydrates on HIV-1: Interaction of oligomannose dendrons with human monoclonal antibody 2G12 and DC-SIGN. Proc Natl Acad Sci U S A 105(10): 3690-3695.
  20. Chen, M. L., Adak, A. K., Yeh, N. C., Yang, W. B., Chuang, Y. J., Wong, C. H., Hwang, K. C., Hwu, J. R., Hsieh, S. L. and Lin, C. C. (2008). Fabrication of an oriented Fc-fused lectin microarray through boronate formation. Angew Chem Int Ed Engl 47(45): 8627-8630.
  21. Tsai, C. M., Chiu, Y. K., Hsu, T. L., Lin, I. Y., Hsieh, S. L. and Lin, K. I. (2008). Galectin-1 promotes immunoglobulin production during plasma cell differentiation. J Immunol 181(7): 4570-4579.
  22. Chang, P. M., Chen, P. M., Hsieh, S. L., Tzeng, C. H., Liu, J. H., Chiou, T. J., Wang, W. S., Yen, C. C., Gau, J. P. and Yang, M. H. (2008). Expression of a soluble decoy receptor 3 in patients with diffuse large B-cell lymphoma predicts clinical outcome. Int J Oncol 33(3): 549-554.
  23. How, C. K., Chern, C. H., Wu, M. F., Wang, L. M., Huang, C. I., Lee, C. H. and Hsieh, S. L.* (2009). Expression of the triggering receptor expressed on myeloid cells-1 mRNA in a heterogeneous infected population. Int J Clin Pract 63(1): 126-133.
  24. Lian, W. N., Chang, C. H., Chen, Y. J., Dao, R. L., Luo, Y. C., Chien, J. Y., Hsieh, S. L. and Lin, C. H. (2007). Intracellular delivery can be achieved by bombarding cells or tissues with accelerated molecules or bacteria without the need for carrier particles. Exp Cell Res 313(1): 53-64.
  25. Tang, C. H., Hsu, T. L., Lin, W. W., Lai, M. Z., Yang, R. S., Hsieh, S. L.** and Fu, W. M.** (2007). Attenuation of bone mass and increase of osteoclast formation in decoy receptor 3 transgenic mice. J Biol Chem 282(4): 2346-2354.
  26. Ho, C. H., Hsu, C. F., Fong, P. F., Tai, S. K., Hsieh, S. L. and Chen, C. J. (2007). Epstein-Barr virus transcription activator Rta upregulates decoy receptor 3 expression by binding to its promoter. J Virol 81(9): 4837-4847.
  27. Ka, S. M., Sytwu, H. K., Chang, D. M., Hsieh, S. L., Tsai, P. Y. and Chen, A. (2007). Decoy receptor 3 ameliorates an autoimmune crescentic glomerulonephritis model in mice. J Am Soc Nephrol 18(9): 2473-2485.
  28. Wei, C. Y., Chou, Y. H., Ho, F. M., Hsieh, S. L. and Lin, W. W. (2006). Signaling pathways of LIGHT induced macrophage migration and vascular smooth muscle cell proliferation. J Cell Physiol 209(3): 735-743.
  29. You, R. I., Chen, M. C., Wang, H. W., Chou, Y. C., Lin, C. H. and Hsieh, S. L.* (2006). Inhibition of lymphotoxin-beta receptor-mediated cell death by survivin-DeltaEx3. Cancer Res 66(6): 3051-3061.
  30. Chen, S. J., Chu, M. L., Wang, C. J., Liao, C. L., Hsieh, S. L., Sytwu, H. K. and Wang, C. C. (2006). Kinetic Th1/Th2 responses of transgenic mice with bacterial meningitis induced by Haemophilus influenzae. Clin Sci (Lond) 111(4): 253-263.
  31. Liu, S. J., Leng, C. H., Lien, S. P., Chi, H. Y., Huang, C. Y., Lin, C. L., Lian, W. C., Chen, C. J., Hsieh, S. L. and Chong, P. (2006). Immunological characterizations of the nucleocapsid protein based SARS vaccine candidates. Vaccine 24(16): 3100-3108.
  32. Su, W. B., Chang, Y. H., Lin, W. W. and Hsieh, S. L.* (2006). Differential regulation of interleukin-8 gene transcription by death receptor 3 (DR3) and type I TNF receptor (TNFRI). Exp Cell Res 312(3): 266-277.
  33. Chang, Y. C., Chan, Y. H., Jackson, D. G. and Hsieh, S. L.* (2006). The glycosaminoglycan-binding domain of decoy receptor 3 is essential for induction of monocyte adhesion. J Immunol 176(1): 173-180.
  34. Lu, Y. T., Yen, C. Y., Ho, H. C., Chen, C. J., Wu, M. F. and Hsieh, S. L. (2006). Preparation and characterization of monoclonal antibody against protein TREM-like transcript-1 (TLT-1). Hybridoma (Larchmt) 25(1): 20-26.
  35. Chen, S. J., Chu, M. L., Wang, C. J., Liao, C. L., Hsieh, S. L., Sytwu, H. K. and Wang, C. C. (2006). Kinetic Th1/Th2 responses of transgenic mice with bacterial meningitis induced by Haemophilus influenzae. Clin Sci (Lond) 111(4): 253-263.
  36. Chen, S. J., Liao, C. L., Hsieh, S. L., Chu, M. L., Fang, M. C., Sytwu, H. K. and Wang, C. C. (2006). Kinetics of adaptive immunity to Haemophilus influenzae type b meningitis in transgenic mice: evidence from diverse expression of double T1/T2 transgenes and Th1/Th2-related cytokines. Immunol Lett 105(1): 6-15.
  37. Chi, K. H., Liu, S. J., Li, C. P., Kuo, H. P., Wang, Y. S., Chao, Y. and Hsieh, S. L. (2005). Combination of conformal radiotherapy and intratumoral injection of adoptive dendritic cell immunotherapy in refractory hepatoma. J Immunother 28(2): 129-135.
  38. Huang, L. F., Liu, Y. K., Lu, C. A., Hsieh, S. L. and Yu, S. M. (2005). Production of human serum albumin by sugar starvation induced promoter and rice cell culture. Transgenic Res 14(5): 569-581.
  39. Wang, P. H., Lee, W. L., Juang, C. M., Yang, Y. H., Lo, W. H., Lai, C. R., Hsieh, S. L. and Yuan, C. C. (2005). Altered mRNA expressions of sialyltransferases in ovarian cancers. Gynecol Oncol 99(3): 631-639.
  40. Yang, C. R., Hsieh, S. L., Ho, F. M. and Lin, W. W. (2005). Decoy receptor 3 increases monocyte adhesion to endothelial cells via NF-kappa B-dependent up-regulation of intercellular adhesion molecule-1, VCAM-1, and IL-8 expression. J Immunol 174(3): 1647-1656.
  41. Chang, Y. H., Hsieh, S. L., Chao, Y., Chou, Y. C. and Lin, W. W. (2005). Proinflammatory effects of LIGHT through HVEM and LTbetaR interactions in cultured human umbilical vein endothelial cells. J Biomed Sci 12(2): 363-375.
  42. Hsu, T. L., Wu, Y. Y., Chang, Y. C., Yang, C. Y., Lai, M. Z., Su, W. B. and Hsieh, S. L.* (2005). Attenuation of Th1 response in decoy receptor 3 transgenic mice. J Immunol 175(8): 5135-5145.
  43. Hung, J. T., Liao, J. H., Lin, Y. C., Chang, H. Y., Wu, S. F., Chang, T. H., Kung, J. T., Hsieh, S. L., McDevitt, H. and Sytwu, H. K. (2005). Immunopathogenic role of TH1 cells in autoimmune diabetes: evidence from a T1 and T2 doubly transgenic non-obese diabetic mouse model. J Autoimmun 25(3): 181-192.
2 Protocols published
Contusion Spinal Cord Injury Rat Model
Authors:  Chuan-Wen Chiu, Henrich Cheng and Shie-Liang Hsieh, date: 06/20/2017, view: 9586, Q&A: 0
Spinal cord injury (SCI) can lead to severe disability, paralysis, neurological deficits and even death. In humans, most spinal cord injuries are caused by transient compression or contusion of the spinal cord associated with motor vehicle ...
Detection of CLEC5A-JEV Interaction by ELISA
Authors:  Szu-Ting Chen and Shie-Liang Hsieh, date: 10/05/2012, view: 9959, Q&A: 0
JEV (Japanese encephalitis virus) belonging to Flaiviridae interacts with CLEC5A (C-type lectin domain family 5, member A), a member of C-type lectin associated with DAP12 signaling protein and expressed on myeloid cell, ...
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