Mashito Sakai Department of Molecular Metabolic Regulation, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Japan
1 protocol

Michihiro Matsumoto
  • Department of Molecular Metabolic Regulation, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Japan
Research focus
  • Biochemistry
  • 1 Author merit


M.D. in Kobe University School of Medicine, Kobe, Japan, 1993.
Ph.D. in Second Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan, 2001

Current position

Director, Department of Molecular Metabolic Regulation, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

Publications (since 2005)

  1. Sakai, M., Matsumoto, M., Tujimura, T., Yongheng, C., Noguchi, T., Inagaki, K., Inoue, H., Hosooka, T., Takazawa, K., Kido, Y., Yasuda, K., Hiramatsu, R., Matsuki, Y. and Kasuga, M. (2012). CITED2 links hormonal signaling to PGC-1alpha acetylation in the regulation of gluconeogenesis. Nat Med 18(4): 612-617.
  2. Kimura, K., Yamada, T., Matsumoto, M., Kido, Y., Hosooka, T., Asahara, S., Matsuda, T., Ota, T., Watanabe, H., Sai, Y., Miyamoto, K., Kaneko, S., Kasuga, M. and Inoue, H. (2012). Endoplasmic reticulum stress inhibits STAT3-dependent suppression of hepatic gluconeogenesis via dephosphorylation and deacetylation. Diabetes 61(1): 61-73.
  3. Nagare, T., Sakaue, H., Matsumoto, M., Cao, Y., Inagaki, K., Sakai, M., Takashima, Y., Nakamura, K., Mori, T., Okada, Y., Matsuki, Y., Watanabe, E., Ikeda, K., Taguchi, R., Kamimura, N., Ohta, S., Hiramatsu, R. and Kasuga, M. (2011). Overexpression of KLF15 transcription factor in adipocytes of mice results in down-regulation of SCD1 protein expression in adipocytes and consequent enhancement of glucose-induced insulin secretion. J Biol Chem 286(43): 37458-37469.
  4. Koyanagi, M., Asahara, S., Matsuda, T., Hashimoto, N., Shigeyama, Y., Shibutani, Y., Kanno, A., Fuchita, M., Mikami, T., Hosooka, T., Inoue, H., Matsumoto, M., Koike, M., Uchiyama, Y., Noda, T., Seino, S., Kasuga, M. and Kido, Y. (2011). Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1. PLoS One 6(8): e23238.
  5. Matsuda, T., Kido, Y., Asahara, S., Kaisho, T., Tanaka, T., Hashimoto, N., Shigeyama, Y., Takeda, A., Inoue, T., Shibutani, Y., Koyanagi, M., Hosooka, T., Matsumoto, M., Inoue, H., Uchida, T., Koike, M., Uchiyama, Y., Akira, S. and Kasuga, M. (2010). Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice. J Clin Invest 120(1): 115-126.
  6. Plum, L., Lin, H. V., Dutia, R., Tanaka, J., Aizawa, K. S., Matsumoto, M., Kim, A. J., Cawley, N. X., Paik, J. H., Loh, Y. P., DePinho, R. A., Wardlaw, S. L. and Accili, D. (2009). The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake. Nat Med 15(10): 1195-1201.
  7. Tanaka, J., Qiang, L., Banks, A. S., Welch, C. L., Matsumoto, M., Kitamura, T., Ido-Kitamura, Y., DePinho, R. A. and Accili, D. (2009). Foxo1 links hyperglycemia to LDL oxidation and endothelial nitric oxide synthase dysfunction in vascular endothelial cells. Diabetes 58(10): 2344-2354.
  8. Han, S., Liang, C. P., Westerterp, M., Senokuchi, T., Welch, C. L., Wang, Q., Matsumoto, M., Accili, D. and Tall, A. R. (2009). Hepatic insulin signaling regulates VLDL secretion and atherogenesis in mice. J Clin Invest 119(4): 1029-1041.
  9. Banks, A. S., Kon, N., Knight, C., Matsumoto, M., Gutierrez-Juarez, R., Rossetti, L., Gu, W. and Accili, D. (2008). SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab 8(4): 333-341.
  10. Senokuchi, T., Liang, C. P., Seimon, T. A., Han, S., Matsumoto, M., Banks, A. S., Paik, J. H., DePinho, R. A., Accili, D., Tabas, I. and Tall, A. R. (2008). Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress. Diabetes 57(11): 2967-2976.
  11. Matsumoto, M., Pocai, A., Rossetti, L., Depinho, R. A. and Accili, D. (2007). Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. Cell Metab 6(3): 208-216.
  12. Matsumoto, M., Han, S., Kitamura, T. and Accili, D. (2006). Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism. J Clin Invest 116(9): 2464-2472.
  13. Inoue, H., Ogawa, W., Asakawa, A., Okamoto, Y., Nishizawa, A., Matsumoto, M., Teshigawara, K., Matsuki, Y., Watanabe, E., Hiramatsu, R., Notohara, K., Katayose, K., Okamura, H., Kahn, C. R., Noda, T., Takeda, K., Akira, S., Inui, A. and Kasuga, M. (2006). Role of hepatic STAT3 in brain-insulin action on hepatic glucose production. Cell Metab 3(4): 267-275.
  14. Matsumoto, M. and Accili, D. (2006). The tangled path to glucose production. Nat Med 12(1): 33-34; discussion 34.
  15. Matsumoto, M. and Accili, D. (2005). All roads lead to FoxO. Cell Metab 1(4): 215-216.
  16. Hashimoto, N., Kido, Y., Uchida, T., Matsuda, T., Suzuki, K., Inoue, H., Matsumoto, M., Ogawa, W., Maeda, S., Fujihara, H., Ueta, Y., Uchiyama, Y., Akimoto, K., Ohno, S., Noda, T. and Kasuga, M. (2005). PKClambda regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic beta cells. J Clin Invest 115(1): 138-145.
  17. Yutsudo, Y., Kido, Y., Okabayashi, Y., Matsumoto, M., Ogawa, W., Ohba, M., Kuroki, T. and Kasuga, M. (2005). Protein kinase Calpha is implicated in cholecystokinin-induced activation of 70-kd S6 kinase in AR42J cells. Pancreas 30(1): 50-53.
1 Protocol published
Authors:  Michihiro Matsumoto and Mashito Sakai, date: 11/05/2012, view: 23292, Q&A: 3
Hepatic glucose production is a primary determinant of fasting hyperglycemia in type 2 diabetic patients. Glucagon-cAMP-PKA pathway increases, but insulin-PI3 kinase-Akt pathway suppresses glucose production. This assay aims to evaluate the ability ...
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