Hsien-Hen Lin Institute of Biotechnology, National Taiwan University
1 protocol

Joyce Kuo Graudate Institute of Anatomy and Cell Biology, National Taiwan University, College of Medicine
1 protocol

Hung-Fu Liao Institute of Biotechnology, National Taiwan University
1 protocol

Shau-Ping Lin
  • Institute of Biotechnology, National Taiwan University
Research focus
  • Cell biology
  • 1 Author merit


Ph.D in Department of Physiology, Development and Neuroscience, University of Cambridge, UK

Current Position

Associate Professor, Institute of Biotechnology, National Taiwan University, Taipei, Taiwan
Genomics and Systems Biology degree program between, Academia Sinica and National Taiwan University
Adjunct Investigator, Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan

Publications (since 2010)

  1. Tseng, Y. T., Liao, H. F., Yu, C. Y., Mo, C. F. and Lin, S. P. (2015). Epigenetic factors in the regulation of prospermatogonia and spermatogonial stem cells. Reproduction 150(3): R77-91.
  2. Liao, H. F., Mo, C. F., Wu, S. C., Cheng, D. H., Yu, C. Y., Chang, K. W., Kao, T. H., Lu, C. W., Pinskaya, M., Morillon, A., Lin, S. S., Cheng, W. T., Bourc'his, D., Bestor, T., Sung, L. Y. and Lin, S. P. (2015). Dnmt3l-knockout donor cells improve somatic cell nuclear transfer reprogramming efficiency. Reproduction 150(4): 245-256.
  3. Chang, K. W., Huang, N. A., Liu, I. H., Wang, Y. H., Wu, P., Tseng, Y. T., Hughes, M. W., Jiang, T. X., Tsai, M. H., Chen, C. Y., Oyang, Y. J., Lin, E. C., Chuong, C. M. and Lin, S. P. (2015). Emergence of Differentially Regulated Pathways Associated with the Development of Regional Specificity in Chicken Skin. BMC Genomics 23: 16:22.
  4. Mo, C. F., Wu, F. C., Tai, K. Y., Chang, W. C., Chang, K. W., Kuo, H. C., Ho, H. N., Chen, H. F. and Lin, S. P. (2015). Loss of non-coding RNA expression from the DLK1-DIO3 imprinted locus correlates with reduced neural differentiation potential in human embryonic stem cell lines. Stem Cell Res Ther 6: 1.
  5. Kao, T. H., Liao, H. F., Wolf, D., Tai, K. Y., Chuang, C. Y., Lee, H. S., Kuo, H. C., Hata, K., Zhang, X., Cheng, X., Goff, S. P., Ooi, S. K., Bestor, T. H. and Lin, S. P. (2014). Ectopic DNMT3L triggers assembly of a repressive complex for retroviral silencing in somatic cells. J Virol 88(18): 10680-10695.
  6. Liao, H. F., Chen, W. S., Chen, Y. H., Kao, T. H., Tseng, Y. T., Lee, C. Y., Chiu, Y. C., Lee, P. L., Lin, Q. J., Ching, Y. H., Hata, K., Cheng, W. T., Tsai, M. H., Sasaki, H., Ho, H. N., Wu, S. C., Huang, Y. H., Yen, P. and Lin, S. P. (2014). DNMT3L promotes quiescence in postnatal spermatogonial progenitor cells. Development 141(12): 2402-2413.
  7. Cheng, C. C., Lee, Y. H., Lin, S. P., Huangfu, W. C. and Liu, I. H. (2014). Cell-autonomous heparanase modulates self-renewal and migration in bone marrow-derived mesenchymal stem cells. Journal of Biomedical Science 21: 21.
  8. Lu, C. H., Lee, R. K., Hwu, Y. M., Lin, M. H., Yeh, L. Y., Chen, Y. J., Lin, S. P., Li, S. H. (2013). Involvement of the serine protease inhibitor, SERPINE2, and the urokinase plasminogen activator in cumulus expansion and oocyte maturation. Involvement of the serine protease inhibitor, SERPINE2, and the urokinase plasminogen activator in cumulus expansion and oocyte maturation. PLoS One 8(8): e74602.
  9. Liao, H. F., Tai, K. Y., Chen, W. S., Cheng, L. C., Ho, H. N. and Lin, S. P. (2012). Functions of DNA methyltransferase 3-like in germ cells and beyond. Biol Cell 104(10): 571-587.
  10. Chang, T. C., Liu, C. C., Hsing, E. W., Liang, S. M., Chi, Y. H., Sung, L. Y., Lin, S. P., Shen, T. L., Ko, B. S., Yen, B. L., Yet, S. F., Wu, K. K. and Liou, J. Y. (2012). 14-3-3sigma regulates beta-catenin-mediated mouse embryonic stem cell proliferation by sequestering GSK-3beta. PLoS One 7(6): e40193.
  11. Chuang, C. Y., Lin, K. I., Hsiao, M., Stone, L., Chen, H. F., Huang, Y. H., Lin, S. P., Ho, H. N. and Kuo, H. C. (2012). Meiotic competent human germ cell-like cells derived from human embryonic stem cells induced by BMP4/WNT3A signaling and OCT4/EpCAM (epithelial cell adhesion molecule) selection. J Biol Chem 287(18): 14389-14401.
  12. Cheng, C. C., Lian, W. S., Hsiao, F. S., Liu, I. H., Lin, S. P., Lee, Y. H., Chang, C. C., Xiao, G. Y., Huang, H. Y., Cheng, C. F., Cheng, W. T. and Wu, S. C. (2012). Isolation and characterization of novel murine epiphysis derived mesenchymal stem cells. PLoS One 7(4): e36085.
  13. Chen, Y. J., Chen, C. C., Li, T. K., Wang, P. H., Liu, L. R., Chang, F. Y., Wang, Y. C., Yu, Y. H., Lin, S. P., Mersmann, H. J. and Ding, S. T. (2012). Docosahexaenoic acid suppresses the expression of FoxO and its target genes. J Nutr Biochem 23(12): 1609-1616.
  14. Hsiao, F. S., Lian, W. S., Lin, S. P., Lin, C. J., Lin, Y. S., Cheng, E. C., Liu, C. W., Cheng, C. C., Cheng, P. H., Ding, S. T., Lee, K. H., Kuo, T. F., Cheng, C. F., Cheng, W. T. and Wu, S. C. (2011). Toward an ideal animal model to trace donor cell fates after stem cell therapy: production of stably labeled multipotent mesenchymal stem cells from bone marrow of transgenic pigs harboring enhanced green fluorescence protein gene. J Anim Sci 89(11): 3460-3472.
  15. Liu, L. R., Lin, S. P., Chen, C. C., Chen, Y. J., Tai, C. C., Chang, S. C., Juang, R. H., Tseng, Y. W., Liu, B. H., Mersmann, H. J., Shen, T. L. and Ding, S. T. (2011). Serum amyloid A induces lipolysis by downregulating perilipin through ERK1/2 and PKA signaling pathways. Obesity (Silver Spring) 19(12): 2301-2309.
  16. Wang, D. Y., Wu, S. C., Lin, S. P., Hsiao, S. H., Chung, T. W. and Huang, Y. Y. (2011). Evaluation of transdifferentiation from mesenchymal stem cells to neuron-like cells using microfluidic patterned co-culture system. Biomed Microdevices 13(3): 517-526.
  17. Lu, C. H., Lee, R. K., Hwu, Y. M., Chu, S. L., Chen, Y. J., Chang, W. C., Lin, S. P. and Li, S. H. (2011). SERPINE2, a serine protease inhibitor extensively expressed in adult male mouse reproductive tissues, may serve as a murine sperm decapacitation factor. Biol Reprod 84(3): 514-525.
  18. Lin, C. Y., Lin, H. H., Tsai, M. H., Lin, S. P. and Chen, M. H. (2011). Zinc chloride for odontogenesis of dental pulp stem cells via metallothionein up-regulation. J Endod 37(2): 211-216.
  19. Schulz, R., Proudhon, C., Bestor, T. H., Woodfine, K., Lin, C. S., Lin, S. P., Prissette, M., Oakey, R. J. and Bourc'his, D. (2010). The parental non-equivalence of imprinting control regions during mammalian development and evolution. PLoS Genet 6(11): e1001214.
  20. Chen, H. F., Kuo, H. C., Lin, S. P., Chien, C. L., Chiang, M. S. and Ho, H. N. (2010). Hypoxic culture maintains self-renewal and enhances embryoid body formation of human embryonic stem cells. Tissue Eng Part A 16(9): 2901-2913.
  21. Hsiao, F. S., Cheng, C. C., Peng, S. Y., Huang, H. Y., Lian, W. S., Jan, M. L., Fang, Y. T., Cheng, E. C., Lee, K. H., Cheng, W. T., Lin, S. P. and Wu, S. C. (2010). Isolation of therapeutically functional mouse bone marrow mesenchymal stem cells within 3 h by an effective single-step plastic-adherent method. Cell Prolif 43(3): 235-248.
1 Protocol published
Authors:  Hung-Fu Liao, Joyce Kuo, Hsien-Hen Lin and Shau-Ping Lin, date: 12/20/2016, view: 8639, Q&A: 0
In mammals, homeostasis of many tissues rely on a subpopulation of cells, referred to as stem cells, to sustain an appropriate number of undifferentiated and differentiated cells. Spermatogonial stem cells (SSCs) provide the fundamental cellular ...
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