Education

Ph.D. in Biochemistry and molecular biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China

Current position

Instructor, Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, Texas, U.S.A

Publications

1. Wang, Y., Su, L., Morin, M. D., Jones, B. T., Whitby, L. R., Surakattula, M. M., Huang, H., Shi, H., Choi, J. H., Wang, K. W., Moresco, E. M., Berger, M., Zhan, X., Zhang, H., Boger, D. L. and Beutler, B. (2016). TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS. Proc Natl Acad Sci U S A 113(7): E884-893.

2. Shi, H., Wang, Y., Li, X., Zhan, X., Tang, M., Fina, M., Su, L., Pratt, D., Bu, C. H., Hildebrand, S., Lyon, S., Scott, L., Quan, J., Sun, Q., Russell, J., Arnett, S., Jurek, P., Chen, D., Kravchenko, V. V., Mathison, J. C., Moresco, E. M., Monson, N. L., Ulevitch, R. J. and Beutler, B. (2016). NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component. Nat Immunol 17(3): 250-258.

3. Wang, T., Zhan, X., Bu, C. H., Lyon, S., Pratt, D., Hildebrand, S., Choi, J. H., Zhang, Z., Zeng, M., Wang, K. W., Turer, E., Chen, Z., Zhang, D., Yue, T., Wang, Y., Shi, H., Wang, J., Sun, L., SoRelle, J., McAlpine, W., Hutchins, N., Zhan, X., Fina, M., Gobert, R., Quan, J., Kreutzer, M., Arnett, S., Hawkins, K., Leach, A., Tate, C., Daniel, C., Reyna, C., Prince, L., Davis, S., Purrington, J., Bearden, R., Weatherly, J., White, D., Russell, J., Sun, Q., Tang, M., Li, X., Scott, L., Moresco, E. M., McInerney, G. M., Karlsson Hedestam, G. B., Xie, Y. and Beutler, B. (2015). Real-time resolution of point mutations that cause phenovariance in mice. Proc Natl Acad Sci U S A 112(5): E440-449.

4. Zeng, M., Hu, Z., Shi, X., Li, X., Zhan, X., Li, X. D., Wang, J., Choi, J. H., Wang, K. W., Purrington, T., Tang, M., Fina, M., DeBerardinis, R. J., Moresco, E. M., Pedersen, G., McInerney, G. M., Karlsson Hedestam, G. B., Chen, Z. J. and Beutler, B. (2014). MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses. Science 346(6216): 1486-1492.

5. Siggs, O. M., Xiao, N., Wang, Y., Shi, H., Tomisato, W., Li, X., Xia, Y. and Beutler, B. (2012). iRhom2 is required for the secretion of mouse TNFalpha. Blood 119(24): 5769-5771.