Kaustabh Ghosh Department of Bioengineering, Program in Cell, Molecular and Developmental Biology, University of California, USA
1 protocol
Francesco Dal Grande Senckenberg Gesellschaft fuer Naturforschung
2 protocols

Giusy Tornillo Cardiff University
5 protocols

Jia Li SRI International
43 protocols

Irit Adini
  • Harvard Medical School
Research focus
  • Molecular biology
  • 1 Author merit


Ph.D. in Microbiology and Molecular Genetics, Hebrew University Hadassah Medical School, Jerusalem, Israel, 2002

Current position

Visiting Project Scientist, Department of Bioengineering, University of California, Riverside


*Corresponding author

  1. Adini, I.*, Adini, A., Bazinet, L., Watnick, R. S., Bielenberg, D. R. and D'Amato, R. J. (2015). Melanocyte pigmentation inversely correlates with MCP-1 production and angiogenesis-inducing potential. FASEB J 29(2): 662-670.
  2. Panigrahy, D., Adini, I., Mamluk, R., Levonyak, N., Bruns, C. J., D'Amore, P. A., Klagsbrun, M. and Bielenberg, D. R. (2014). Regulation of soluble neuropilin 1, an endogenous angiogenesis inhibitor, in liver development and regeneration. Pathology 46(5): 416-423.
  3. Adini, I.*, Ghosh, K., Adini, A., Chi, Z. L., Yoshimura, T., Benny, O., Connor, K. M., Rogers, M. S., Bazinet, L., Birsner, A. E., Bielenberg, D. R. and D'Amato, R. J. (2014). Melanocyte-secreted fibromodulin promotes an angiogenic microenvironment. J Clin Invest 124(1): 425-436.
  4. Kontos, C. D. (2014). More than skin deep: connecting melanocyte pigmentation and angiogenic diseases. J Clin Invest 124(1): 76-79. 
  5. Adini, A., Adini, I., Ghosh, K., Benny, O., Pravda, E., Hu, R., Luyindula, D. and D'Amato, R. J. (2013). The stem cell marker prominin-1/CD133 interacts with vascular endothelial growth factor and potentiates its action. Angiogenesis 16(2): 405-416.
  6. Gerald, D., Adini, I., Shechter, S., Perruzzi, C., Varnau, J., Hopkins, B., Pravda, E., Kurschat, P., Klagsbrun, M., Prendergast, G. C., Stuhlmann, H., Rigby, A. C., Nagy, J. A. and L. E. (2013). Benjamin nuclear RhoB-VEZF1 complex regulates the differential response of blood versus lymphatic endothelium to stress. Nat Commun 4:2824.
  7. Rogers, M. S., Adini, I., McBride, A. F., Birsner, A. E. and D'Amato, R. J. (2013). The albino mutation of tyrosinase alters ocular angiogenic responsiveness. Angiogenesis 16(3): 639-646. 
  8. Spivey, K. A., Chung, I., Banyard, J., Adini, I., Feldman, H. A. and Zetter, B. R. (2012). A role for collagen XXIII in cancer cell adhesion, anchorage-independence and metastasis. Oncogene 31(18): 2362-2372.
  9. Greenberger, S., Adini, I., Boscolo, E., Mulliken, J. B. and Bischoff, J. (2010). Targeting NF-kappaB in infantile hemangioma-derived stem cells reduces VEGF-A expression. Angiogenesis 13(4): 327-335. 
  10. Greenberger, S., Boscolo, E., Adini, I., Mulliken, J. B. and Bischoff, J. (2010). Corticosteroid suppression of VEGF-A in infantile hemangioma-derived stem cells. N Engl J Med 362(11): 1005-1013.
  11. Sun, J., Hopkins, B. D., Tsujikawa, K., Perruzzi, C., Adini, I., Swerlick, R., Bornstein, P., Lawler, J. and Benjamin, L. E. (2009). Thrombospondin-1 modulates VEGF-A-mediated Akt signaling and capillary survival in the developing retina. Am J Physiol Heart Circ Physiol 296(5): H1344-1351. 
  12. Fainaru, O.*, Adini, I.*, Benny, O., Bazinet, L., Pravda, E., D'Amato, R. and Folkman, J. (2008). Doxycycline induces membrane expression of VE-cadherin on endothelial cells and prevents vascular hyperpermeability. FASEB J 22(10): 3728-3735.
  13. Benny, O., Fainaru, O., Adini, A., Cassiola, F., Bazinet, L., Adini, I., Pravda, E., Nahmias, Y., Koirala, S., Corfas, G., D'Amato, R. J. and Folkman, J. (2008). An orally delivered small-molecule formulation with antiangiogenic and anticancer activity. Nat Biotechnol 26(7): 799-807.
  14. Fainaru, O., Adini, A., Benny, O., Adini, I., Short, S., Bazinet, L., Nakai, K., Pravda, E., Hornstein, M. D., D'Amato, R. J. and Folkman, J. (2008). Dendritic cells support angiogenesis and promote lesion growth in a murine model of endometriosis. FASEB J 22(2): 522-529.
  15. Pakneshan, P., Birsner, A. E., Adini, I., Becker, C. M. and D’Amato, R. J. (2008). Suppression of vascular permeability and corneal angiogenesis by non-steroidal anti-inflammatory drugs. Investigative Opthalmology and Visual Sciences 49(9): 3909-13.
  16. Adini, I., Ephros, M., Chen, J. and Jaffe, C. L. (2003). Asymptomatic visceral leishmaniasis, northern Israel. Emerg Infect Dis 9(3): 397-398.
  17. Adini, I., Rabinovitz, I., Sun, J. F., Prendergast, G. C. and Benjamin, L. E. (2003). RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development. Genes Dev 17(21): 2721-2732.
  18. Baneth, G., Dank, G., Keren-Kornblatt, E., Sekeles, E., Adini, I., Eisenberger, C. L., Schnur, L. F., King, R. and Jaffe, C. L. (1998). Emergence of visceral leishmaniasis in central Israel. Am J Trop Med Hyg 59(5): 722-725.
  19. Adini, I., Jacobson, R. L., Kasap, M., Schlein, Y. and Jaffe, C. L. (1998). Species-specific detection of Leishmania in sandflies using an enzyme-linked immunosorbent assay. Trans R Soc Trop Med Hyg 92(1): 35-37.
1 Protocol published
Mouse Retinal Whole Mounts and Quantification of Vasculature Protocol
Authors:  Irit Adini and Kaustabh Ghosh, date: 08/05/2015, view: 6135, Q&A: 0
Angiogenesis is the formation of new blood vessels from a pre-existing vascular bed. It is a multi-step process beginning with enzymatic degradation of the capillary basement membrane, followed by endothelial cell (EC) proliferation, migration, tube ...
3 Protocols reviewed
Ex vivo Trophoblast-specific Genetic Manipulation Using Lentiviral Delivery
Authors:  Damayanti Chakraborty, Masanaga Muto and Michael J. Soares, date: 12/20/2017, view: 874, Q&A: 0
In this protocol report, we describe a lentiviral gene delivery technique for genetic modification of the rat trophoblast cell lineage. Lentiviral packaged gene constructs can be efficiently and specifically delivered to the trophoblast cell lineage ...
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Isolation, Culture, and Staining of Single Myofibers
Authors:  Yann Simon Gallot, Sajedah M. Hindi, Aman K. Mann and Ashok Kumar, date: 10/05/2016, view: 4217, Q&A: 0
Adult skeletal muscle regeneration is orchestrated by a specialized population of adult stem cells called satellite cells, which are localized between the basal lamina and the plasma membrane of myofibers. The process of satellite cell-activation, ...
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