Meng-Tsen Ke Laboratory for Sensory Circuit Formation, RIKEN Center for Developmental Biology, Japan
3 protocols

Satoshi Fujimoto Kyushu University
1 protocol

Takeshi Imai
  • Professor, Graduate School of Medical Sciences, Kyushu University, Japan
Research focus
  • Neuroscience and Developmental Biology
  • 3 Author merit


Ph.D. in Biophysics and Biochemistry, The University of Tokyo, Japan, 2006

Current position

Professor, Graduate School of Medical Sciences, Kyushu University, Japan

Publications (selected)

  1. Google Scholar:
  2. Iwata, R., Kiyonari, H. and Imai, T. (2017). Mechanosensory-Based Phase Coding of Odor Identity in the Olfactory Bulb. Neuron 96(5): 1139-1152 e1137. 
  3. Ke, M. T., Nakai, Y., Fujimoto, S., Takayama, R., Yoshida, S., Kitajima, T. S., Sato, M. and Imai, T. (2016). Super-Resolution Mapping of Neuronal Circuitry With an Index-Optimized Clearing Agent. Cell Rep 14(11): 2718-2732. 
  4. Nakashima, A.*, Takeuchi, H.*, Imai, T.*, Saito, H., Kiyonari, H., Abe, T., Chen, M., Weinstein, L. S., Yu, C. R., Storm, D. R., Nishizumi, H. and Sakano, H. (2013). Agonist-independent GPCR activity regulates anterior-posterior targeting of olfactory sensory neurons. Cell 154(6): 1314-1325. (*Equally contributed)
  5. Ke, M. T., Fujimoto, S. and Imai, T. (2013). SeeDB: a simple and morphology-preserving optical clearing agent for neuronal circuit reconstruction. Nat Neurosci 16(8): 1154-1161.
  6. Imai, T., Sakano, H. and Vosshall, L. B. (2010). Topographic mapping--the olfactory system. Cold Spring Harb Perspect Biol 2(8): a001776. (Review)
  7. Imai, T., Yamazaki, T., Kobayakawa, R., Kobayakawa, K., Abe, T., Suzuki, M. and Sakano, H. (2009). Pre-target axon sorting establishes the neural map topography. Science 325(5940): 585-590.
  8. Imai, T., Suzuki, M. and Sakano, H. (2006). Odorant receptor-derived cAMP signals direct axonal targeting. Science 314(5799): 657-661.
3 Protocols published
Optical Clearing and Index Matching of Tissue Samples for High-resolution Fluorescence Imaging Using SeeDB2
Authors:  Meng-Tsen Ke and Takeshi Imai, date: 10/20/2018, view: 7104, Q&A: 1
Tissue clearing techniques are useful for large-scale three-dimensional fluorescence imaging of thick tissues. However, high-resolution imaging deep inside tissues has been challenging, as it is extremely sensitive to light scattering and spherical ...
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