Education
Ph.D. in Immunology, Graduate Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan, 1995
Current position
Research Fellow, Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan
Publications (since 2005)
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Chuang, H. C., Huang, T. N., and Hsueh, Y. P. (2014). Neuronal excitation up-regulates Tbr1, a high-confidence risk gene of autism, mediating Grin2b expression in the adult brain. Frontiers in Cellular Neuroscience 8:280.
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Hu, H. T. and Hsueh, Y. P. (2014). Calcium influx and postsynaptic proteins coordinate the dendritic filopodium-spine transition. Dev Neurobiol 74(10): 1011-1029.
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Liu, H. Y.* Chen, C. Y.* and Hsueh, Y. P.* (2014). Innate immune responses regulate morphogenesis and degeneration: roles of Toll-like receptors and Sarm1 in neurons. Neurosci Bull 30(4): 645-654. (Invited review; *Co-corresponding authors)
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Shih, P. Y., Lee, S. P., Chen, Y. K. and Hsueh, Y. P. (2014). Cortactin-binding protein 2 increases microtubule stability and regulates dendritic arborization. J Cell Sci 127(Pt 16): 3521-3534.
*Highlighted by cover image and “In this issue” of JCS
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Lin, C. W., Chen, C. Y., Cheng, S. J., Hu, H. T. and Hsueh, Y. P. (2014). Sarm1 deficiency impairs synaptic function and leads to behavioral deficits, which can be ameliorated by an mGluR allosteric modulator. Front Cell Neurosci 8: 87.
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Lin, C. W. and Hsueh, Y. P. (2014). Sarm1, a neuronal inflammatory regulator, controls social interaction, associative memory and cognitive flexibility in mice. Brain Behav Immun 37: 142-151.
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Lin, C. W., Liu, H. Y., Chen, C. Y. and Hsueh, Y. P. (2014). Neuronally-expressed Sarm1 regulates expression of inflammatory and antiviral cytokines in brains. Innate Immun 20(2): 161-172. (First published online ahead on June 10, 2013)
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Huang, T. N.*, Chuang, H. C.*, Chou, W. H., Chen, C. Y., Wang, H. F., Chou, S. J. and Hsueh, Y. P. (2014). Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality. Nat Neurosci 17(2): 240-247. (*Co-first authors)
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Liu, H. Y., Hong, Y. F., Huang, C. M., Chen, C. Y., Huang, T. N. and Hsueh, Y. P. (2013). TLR7 negatively regulates dendrite outgrowth through the Myd88-c-Fos-IL-6 pathway. J Neurosci 33(28): 11479-11493.
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Gnanasekaran, A., Sundukova, M., Hullugundi, S., Birsa, N., Bianchini, G., Hsueh, Y. P., Nistri, A. and Fabbretti, E. (2013). Calcium/calmodulin-dependent serine protein kinase (CASK) is a new intracellular modulator of P2X3 receptors. J Neurochem 126(1): 102-112.
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Chen, Y. K., Chen, C. Y., Hu, H. T. and Hsueh, Y. P. (2012). CTTNBP2, but not CTTNBP2NL, regulates dendritic spinogenesis and synaptic distribution of the striatin-PP2A complex. Mol Biol Cell 23(22): 4383-4392.
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Hsueh, Y. P. (2012). Neuron-specific regulation on F-actin cytoskeletons: The role of CTTNBP2 in dendritic spinogenesis and maintenance. Commun Integr Biol 5(4): 334-336. (Invited short communication)
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Hsueh, Y. P. (2012). From neurodevelopment to neurodegeneration: the interaction of neurofibromin and valosin-containing protein/p97 in regulation of dendritic spine formation. J Biomed Sci 19: 33. (Invited review)
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Chen, Y. K. and Hsueh, Y. P. (2012). Cortactin-binding protein 2 modulates the mobility of cortactin and regulates dendritic spine formation and maintenance. J Neurosci 32(3): 1043-1055.
*Highlighted by cover image and “This week in the Journal” of JN
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Wang, H. F. #, Shih, Y. T. #, Chen, C. Y. #, Chao, H. W., Lee, M. J. * and Hsueh, Y. P. * (2011). Valosin-containing protein and neurofibromin interact to regulate dendritic spine density. J Clin Invest 121(12): 4820-4837. (#Co-first authors; *Co-corresponding authors)
*Highlighted by a commentary in the same issue of JCI
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Hsueh, Y. P. (2011). A versatile player. J Mol Biol 412(1): 1-2. (Invited commentary on “The molecular Basis of the Caskin1 and Mint1 interaction with CASK” by Stafford et al., JMB 412:3-13).
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Chung, W. C., Huang, T. N. and Hsueh, Y. P. (2011). Targeted deletion of CASK-interacting nucleosome assembly protein causes higher locomotor and exploratory activities. Neurosignals 19(3): 128-141.
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Chen, C. Y., Lin, C. W., Chang, C. Y., Jiang, S. T. and Hsueh, Y. P. (2011). Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology. J Cell Biol 193(4): 769-784.
*Selected for early release
*Ranked up to #24 of the most-read articles in JCB
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Kuo, T. Y., Chen, C. Y. and Hsueh, Y. P. (2010). Bcl11A/CTIP1 mediates the effect of the glutamate receptor on axon branching and dendrite outgrowth. J Neurochem 114(5): 1381-1392.
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Kuo, T. Y., Hong, C. J., Chien, H. L. and Hsueh, Y. P. (2010). X-linked mental retardation gene CASK interacts with Bcl11A/CTIP1 and regulates axon branching and outgrowth. J Neurosci Res 88(11): 2364-2373.
*Selected as cover for the issue
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Huang, T. N., Chang, H. P. and Hsueh, Y. P. (2010). CASK phosphorylation by PKA regulates the protein-protein interactions of CASK and expression of the NMDAR2b gene. J Neurochem 112(6): 1562-1573.
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Hsueh, Y. P. (2009). Calcium/calmodulin-dependent serine protein kinase and mental retardation. Ann Neurol 66(4): 438-443. (Invited review)
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Kuo, T. Y., Hong, C. J. and Hsueh, Y. P. (2009). Bcl11A/CTIP1 regulates expression of DCC and MAP1b in control of axon branching and dendrite outgrowth. Mol Cell Neurosci 42(3): 195-207.
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Huang, T. N. and Hsueh, Y. P. (2009). CASK point mutation regulates protein-protein interactions and NR2b promoter activity. Biochem Biophys Res Commun 382(1): 219-222.
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Chao, H. W., Hong, C. J., Huang, T. N., Lin, Y. L. and Hsueh, Y. P. (2008). SUMOylation of the MAGUK protein CASK regulates dendritic spinogenesis. J Cell Biol 182(1): 141-155.
*Selected for early release
*Highlighted by Faculty of 1000 Biology
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Lin, Y. L. and Hsueh, Y. P. (2008). Neurofibromin interacts with CRMP-2 and CRMP-4 in rat brain. Biochem Biophys Res Commun 369(2): 747-752.
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Samuels, B. A., Hsueh, Y. P., Shu, T., Liang, H., Tseng, H. C., Hong, C. J., Su, S. C., Volker, J., Neve, R. L., Yue, D. T. and Tsai, L. H. (2007). Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK. Neuron 56(5): 823-837.
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Hsueh, Y. P. (2007). Transcriptional Regulation of the Tbr1-CASK-CINAP Protein Complex in Response to Neuronal Activity. In: Dudek, S. (ed). The Regulation of Transcription by Neuronal Activity. Springer Science Publishing. (Invited book chapter)
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Hsueh, Y. P. (2007). Neurofibromin signaling and synapses. J Biomed Sci 14(4): 461-466. (Invited review)
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Lin, Y. L., Lei, Y. T., Hong, C. J. and Hsueh, Y. P. (2007). Syndecan-2 induces filopodia and dendritic spine formation via the neurofibromin-PKA-Ena/VASP pathway. J Cell Biol 177(5): 829-841.
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Kuo, T. Y. and Hsueh, Y. P. (2007). Expression of zinc finger transcription factor Bcl11A/Evi9/CTIP1 in rat brain. J Neurosci Res 85(8): 1628-1636.
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Su, K. Y., Chien, W. L., Fu, W. M., Yu, I. S., Huang, H. P., Huang, P. H., Lin, S. R., Shih, J. Y., Lin, Y. L., Hsueh, Y. P., Yang, P. C. and Lin, S. W. (2007). Mice deficient in collapsin response mediator protein-1 exhibit impaired long-term potentiation and impaired spatial learning and memory. J Neurosci 27(10): 2513-2524.
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Hong, C. J. and Hsueh, Y. P. (2007). Cytoplasmic distribution of T-box transcription factor Tbr-1 in adult rodent brain. J Chem Neuroanat 33(3): 124-130.
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Hong, C. J. and Hsueh, Y. P. (2006). CASK associates with glutamate receptor interacting protein and signaling molecules. Biochem Biophys Res Commun 351(3): 771-776.
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Hsueh, Y. P. (2006). The role of the MAGUK protein CASK in neural development and synaptic function. Curr Med Chem 13(16): 1915-1927.
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Lin, C. W., Huang, T. N., Wang, G. S., Kuo, T. Y., Yen, T. Y. and Hsueh, Y. P. (2006). Neural activity- and development-dependent expression and distribution of CASK interacting nucleosome assembly protein in mouse brain. J Comp Neurol 494(4): 606-619.