Fanglian He Bio-protocol
205 protocols

Jyotiska Chaudhuri Buck Institute for Research on Aging
28 protocols

Kristin Shingler University of Minnesota School of Dentistry
16 protocols

Michael Enos Stanford University
16 protocols

Peichuan Zhang
  • Research scientist, Calico Life Sciences
Research focus
  • Molecular biology
  • Aging, genetics, C. elegans
  • 5 Author merit


PhD, Pennsylvania State University, 2003

Lab information

Cynthia Kenyon


1) Mack, H.I.D., Zhang, P., Fonslow, B.R., and Yates, J.R. The protein kinase MBK-1 contributes to lifespan extension in daf-2 mutant and germline-deficient Caenorhabditis elegans. Aging (Albany NY). 2017. [Epub ahead of print]

2) Zhang, P., Judy, M., Lee, S.J., and Kenyon, C. Direct and indirect gene regulation by a life-extending FOXO protein in C. elegans: roles for GATA factors and lipid gene regulators. Cell Metabolism. 2013. 17:85-100.

3) Henis-Korenblit, S., Zhang, P., Hansen, M., McCormick, M., Lee, S.J., Cary, M., and Kenyon, C. Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity. Proc Natl Acad Sci U S A. 2010. 107:9730-5.

4) Yamawaki, T.M., Arantes-Oliveira, N., Berman, J.R., Zhang, P., and Kenyon, C. Independent activities of the germline and somatic reproductive tissues in the regulation of C. elegans’ lifespan. Genetics. 2008. 178:513-26.
5 Protocols published
Analysis of Mouse Liver Glycogen Content
Author:  Peichuan Zhang, date: 05/20/2012, view: 31715, Q&A: 11
Liver is the major site for glycogen storage. Glycogen content can be significantly altered upon disruption of glucose homeostasis in metabolic syndromes, such as diabetes. Glycogen content can be determined by an acid-hydrolysis method ...
Alcian Blue – Alizarin Red Staining of Mouse Skeleton
Author:  Peichuan Zhang, date: 04/20/2012, view: 25706, Q&A: 8
Our lab has used the Alcian blue – Alizarin red staining method with certain modifications to characterize skeleton deformities in mice lacking Pek/Perk, encoding a translational control eIF2alpha kinase.
2 Protocols reviewed
Chemotaxis and Jumping Assays in Nematodes
Authors:  Tiffany Baiocchi and Adler R. Dillman, date: 09/20/2015, view: 7090, Q&A: 0
Nematodes have sensitive olfactory perception, which is used to detect and differentiate many volatile odorants. Some odorants are attractive, others repulsive, and yet others evoke no particular response. Chemotaxis assays can be used to determine ...
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Lipid Extraction from Mouse Feces
Authors:  Daniel Kraus, Qin Yang and Barbara B. Kahn, date: 01/05/2015, view: 11974, Q&A: 0
The analysis of feces composition is important for the study of energy metabolism, which comprises various measurements of energy intake, energy expenditure, and energy wasting. The current protocol describes how to measure energy-dense lipids in ...
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12 Protocols edited
Artificial Optogenetic TRN Stimulation of C. elegans
Authors:  Ithai Rabinowitch, Millet Treinin and Jihong Bai, date: 10/20/2016, view: 4851, Q&A: 0
Optogenetics is a powerful tool for manipulating neuronal activity with high temporal and spatial precision. In the nematode C. elegans optogentics is especially useful and easy to apply. This is because C. elegans is translucent, ...
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Evaluation of Burkholderia cepacia Complex Bacteria Pathogenicity Using Caenorhabditis elegans
Authors:  Pietro Tedesco, Elia Di Schiavi, Fortunato Palma Esposito and Donatella de Pascale, date: 10/20/2016, view: 4042, Q&A: 0
This protocol describes two biological assays to evaluate pathogenicity of Burkholderia cepacia complex (Bcc) strains against the nematode Caenorhabditis elegans. Specifically, these two assays allow one to identify if the ...
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