Peter Steven Zammit
  • Faculty, King's College London
Research focus
  • Cell biology
  • Muscle cell function in health and disease
  • 0 Author merit

Lab information

Peter Zammit Lab
https://www.kcl.ac.uk/research/the-zammit-group

Publications

• Pruller, J., Hofer, I., Ganassi, M., Heher, P., Ma, M.T. and Zammit, P.S. (2021). A human Myogenin promoter modified to be highly active in alveolar rhabdomyosarcoma drives an effective suicide gene therapy. Cancer Gene Therapy 28: 427-441 (10.1038/s41417-020-00225-0).
• Ganassi, M., Badodi, S., Wanders, K., Zammit, P.S. and Hughes, S.M. (2020). Myogenin is an Essential Regulator of Adult Myofibre Growth and Muscle Stem Cell Homeostasis. eLife 9, e60445 (10.7554/eLife.60445).
• Banerji, C.R.S., Henderson, D., Tawil, R.N. and Zammit, P.S. (2020). Skeletal muscle regeneration in Facioscapulohumeral muscular dystrophy is correlated with pathological severity. Human Molecular Genetics 29, 2746–2760 (10.1093/hmg/ddaa164).
• Banerji, C.R.S., Panamarova Macura, M. and Zammit, P.S. (2020). DUX4-expressing immortalised FSHD lymphoblastoid cells express genes elevated in FSHD muscle biopsies, correlating with the early stages of inflammation. Human Molecular Genetics 29, 2285–2299 (10.1093/hmg/ddaa053).
• Banerji, C.R.S., Cammish, P., Evangelista, T., Zammit, P.S., Straub, V. and Marini-Bettolo, C. (2020). Facioscapulohumeral muscular dystrophy 1 patients participating in the UK FSHD registry can be subdivided into 4 patterns of self-reported symptoms. Neuromuscul Disord. 30, 315-328. (10.1016/j.nmd.2020.03.001).
• Bourke, S., Teijeiro Gonzalez, Y., Donà, F., Panamarova, M., Suhling, K., Eggert, U., Dailey, L.A., Zammit, P. and Green, M.A. (2020). Cellular imaging using emission-tuneable conjugated polymer nanoparticles. RSC Adv. 9: 37971 (10.1039/c9ra07983a).
• Pruller J. and Zammit P.S. (2020). Overview of cell types capable of contributing to skeletal muscle repair and regeneration. In: Gimble J., Presen D.M., Oreffo R.O.C., Wolbank S. and Redl, H. (editors). Reference Series in Biomedical Engineering. Springer Nature Switzerland AG 2020, Cell Engineering and Regeneration 3-32 (doi.org/10.1007/978-3-319-08831-0_2)
• Figeac, N., Prüller, J., Hofer, I., Fortier, M., Ortuste Quiroga H., Banerji C.R.S. and Zammit, P.S. (2019). DEPDC1B is a key regulator of myoblast proliferation in mouse and man. Cell Prolif. e12717 (10.1111/cpr.12717).
• Brayson, D., Frustaci, A., Verardo, R., Chimenti, C., Russo, M.A., Hayward, R., Ahmad, S.M., Vizcay-Barrena, G., Protti, A., Zammit, P.S., dos Remedios, C.G., Ehler, E., Shah, A.M. and Shanahan, C.M. (2019). Prelamin A mediates myocardial inflammation in dilated and 1 HIV associated cardiomyopathies. JCI Insight 4: e126315. (10.1172/jci.insight.126315).
• Ross, J.A., Levy, Y., Ripolone, M., Kolb, J.S., Turmaine, M., Holt, M., Lindqvist, J., Claeys, K.G., Weis, J., Monforte, M., Tasca, G., Moggio, M., Figeac, N., Zammit, P.S., Jungbluth, H., Fiorillo, C., Vissing, J., Witting, N., Granzier, H., Zanoteli, E., Hardeman, E.C., Wallgren-Pettersson, C. and Ochala, J. (2019). Impairments in contractility and cytoskeletal organisation cause nuclear defects in nemaline myopathy. Acta Neuropathologica 138, 477-495 (10.1007/s00401-019-02034-8).
• Figeac, N., Mohamed, A.D., Congshan, S., Schonfelder, M., Matallanas, D., Garcia-Munoz, A., Missiaglia E., Collie-Duguid, E., De Mello, V., Pobbati, A.V., Pruller, J., Jaka, O., Harridge, S.D.R., Hong, W., Shipley, J., Vargesson, N., Zammit, P.S.* and Wackerhage, H. (2019). Vgll3 operates via Tead1, Tead3 and Tead4 to influence myogenesis in skeletal muscle. J. Cell Sci. 132, jcs225946. (doi: 10.1242/jcs.225946) (*joint corresponding and senior author).
• Banerji C.R.S. and Zammit P.S (2019). PAX7 target gene repression is a superior FSHD biomarker than DUX4 target gene activation, associating with pathological severity and identifying FSHD at the single cell level. Human Molecular Genetics 28, 2224-2236 (doi: 10.1093/hmg/ddz043).
• Lahmann I., Bröhl D., Zyrianova T., Isomura A., Czajkowski M.T., Kapoor V., Griger J., Ruffault P.-L., Mademtzoglou D., Zammit P.S., Wunderlich T., Spuler S., Kühn R., Preibisch S., Wolf J., Kageyama R. and Birchmeier C. (2019). Oscillations of MyoD and Hes1 proteins regulate the maintenance of activated muscle stem cells. Genes and Development 33, 524-535 (doi: 10.1101/gad.322818.118).
• Banerji C.R.S., Panamarova M., Pruller J., Figeac N., Hebaishi H., Fidanis E., Saxena A., Contet J., Sacconi S., Severini S. and Zammit P.S (2019). Dynamic transcriptomic analysis reveals suppression of PGC1α/ERRα drives perturbed myogenesis in facioscapulohumeral muscular dystrophy. Human Molecular Genetics 28, 1244-1259 (doi: 10.1093/hmg/ddy405)
• Morgan, J., Butler-Browne, G., Muntoni, F., Patel, K.; Skeletal muscle stem cells involvement in pathology study group (Amthor, H., Birchmeier, C., Bonaldo, P., Bönnemann, C., Browne G.B., Chaturvedi, D., Davenport, R., Ferreiro, A., Furling, D., Giordani, L., Grounds, M., Jungbluth, H., Muñoz-Cánoves, P., Mishra, P., Morgan, J., Muntoni, F., Padberg, G., Paradas, C., Partridge, T., Patel, K., Relaix, F., Rüegg, M., Stevenson, A., Van Putten, M., Wood, A., Zammit, P.)(2019). 240th ENMC workshop: The involvement of skeletal muscle stem cells in the pathology of muscular dystrophies 25-27 January 2019, Hoofddorp, The Netherlands. Neuromuscul Disord. 29(9), 704-715. (doi: 10.1016/j.nmd.2019.07.003)
• Steele-Stallard H., Pinton L., Sarcar S., Ozdemir T., Maffioletti S., Zammit P.S.* and Tedesco F.S. (2018). Modelling Skeletal Muscle Laminopathies Using Human Induced Pluripotent Stem Cells Carrying Disease-Causing LMNA mutations. Frontiers in Physiology 9, 1332. (doi: 10.3389/fphys.2018.01332) (*joint corresponding and senior author)
• Ganassi M., Badodi S., Ortuste Quiroga H., Zammit P.S., Hinits Y. and Hughes S.M. (2018). Myogenin controls muscle size by promoting myocyte fusion to balance fibre number and size. Nature Communications 9, 4232 (DOI: 10.1038/s41467-018-06583-6).
• Prüller J., Mannhardt I., Eschenhagen T., Zammit P.S.* and Figeac N. (2018). Satellite cells delivered in their niche efficiently generate functional myotubes in three-dimensional cell culture. PLoS ONE 13(9): e0202574. (doi.org/10.1371/ journal.pone.0202574) (*corresponding and joint senior author).
• Alonso-Martin S., Auradé F., Mademtzoglou D, Rochat A., Zammit P.S., and Relaix F. (2018). SOXF factors regulate murine satellite cell self-renewal and function through inhibition of β-catenin activity. eLife 7:e26039. (doi.org/10.7554/eLife.26039)
• Maffioletti S.M., Sarcar S., Henderson A.B.H., Mannhardt I., Pinton L., Moyle L.A., Steele-Stallard H., Cappellari O., Wells K.E., Ferrari G., Mitchell J.S., Tyzack G.E., Kotiadis V.N., Khedr M., Ragazzi M., Wang W., Duchen M.R., Patani R., Zammit P.S., Wells D.J., Eschenhagen T. and Tedesco F.S. (2018). Three-dimensional Human iPSC-derived Artifical Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering. Cell Reports 23, 899–908 (doi.org/10.1016/j.celrep.2018.03.091)
• Rayagiri S.S., Ranaldi D., Raven A., Mohamad Azhar N.I.F., Lefebvre O., Zammit, P.S., and Borycki A.-G.(2018). Basal lamina remodeling at the skeletal muscle stem cell niche mediates stem cell self-renewal. Nature Communications 9: 1075 (DOI: 10.1038/s41467-018-03425-3).
• Low S.H., Barnes J.L., Zammit, P.S. and Beauchamp, J.R. (2018). Delta-like 4 activates Notch3 to regulate self-renewal in skeletal muscle stem cells. Stem Cells 36: 458–466 (doi.org/10.1002/stem.2757).
• Banerji C.R.S., Panamarova M., Hebaishi H., White R.B., Relaix F., Severini S. and Zammit P.S. (2017). PAX7 target genes are globally repressed in FSHD skeletal muscle. Nature Communications 8: 2152 (10.1038/s41467-017-01200-4)
• Zammit, P. S. (2017). Function of the myogenic regulatory factors Myf5, MyoD, Myogenin and MRF4 in skeletal muscle, satellite cells and regenerative myogenesis. Semin. Cell Dev. Biol. 72,19-32 (doi: 10.1016/j.semcdb.2017.11.011).
• Sun C., De Mello V., Mohamed A., Ortuste Quiroga H.P., Garcia-Munoz A., Al Bloshi A., Tremblay A.M., von Kriegsheim A., Collie-Duguid E., Vargesson N., Matallanas D., Wackerhage H. and Zammit P.S. (2017). Common and distinctive functions of the Hippo effectors Yap and Taz in muscle stem cell function. Stem Cells: 35:1958–1972 (DOI: 10.1002/stem.2652).
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