David Mann Life Sciences Imperial College London
1 protocol

Gregory Craven Chemical Biology University of Leeds
1 protocol

Alan Armstrong
  • Professor, Department of Chemistry Imperial College London
Research focus
  • Chemistry, chemical biology
  • 1 Author merit


PhD, Imperial College London


1 Protocol published
Quantitative Irreversible Tethering (qIT) for Target-directed Covalent Fragment Screening
Authors:  Gregory B. Craven, David J. Mann and Alan Armstrong, date: 12/20/2020, view: 921, Q&A: 0

Small molecules that react to form covalent bonds with proteins are widely used as biological tools and therapeutic agents. Screening cysteine-reactive fragments against a protein target is an efficient way to identify chemical starting points for

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