Marina Moraes Mourão
  • Research scientist, Instituto René Rachou
Research focus
  • Molecular biology
  • Neglected Tropical Diseases, Schistosomiasis, Functional Genomics, Transcriptomics, Drug Discovery, Host-parasite Interaction, Trans-splicing.
  • 0 Author merit

Education

PhD, Federal University of Minas Gerais- UFMG, 2009

Lab information

Medical Helminthology and Malacology

Publications

1.
MOREIRA, B. P. ; ARMSTRONG, T. ; Batista, I. C. A. ; PAULA, N. C. C. S. T. ; MOURÃO, M. M. ; FALCONE, FRANCO HARALD ; Dekker, L. . Use of BODIPY-Labeled ATP Analogues in the Development and Validation of a Fluorescence Polarization-Based Assay for Screening of Kinase Inhibitors. ACS Omega, p. 1, 2020.

2.
PAULA, N. C. C. S. T. ; GAVA, S. G. ; TORRES, G. P. ; PAIVA, C. E. S. ; MOREIRA, B. P. ; LUNKES, FMN ; Montressor, L. ; CALDEIRA, R. L. ; MOURÃO, M. M. . Schistosoma mansoni FES Tyrosine kinase involvement in the mammalian schistosomiasis outcome and miracidia infection capability in Biomphalaria glabrata. Frontiers in Microbiology, v. Abril, p. 1, 2020.

3.
CARNEIRO, V. C. ; SILVA, I. C. A. ; AMARAL, M. S. ; PEREIRA, A. S. ; SILVEIRA, G. O. ; PIRES, D. S. ; DEKKER, F. J. ; ROTILI, D. ; MAI, A. ; TORRES, E. J. L. ; SIPPL, W. ; BORRELLO, M. T. ; GANESAN, A. ; LANCELOT, J. ; THIENGO, S. ; FERNANDEZ, M. A. ; VICENTINO, A. R. R. ; PIERCE, R. J. ; VERJOVSKI, S. A. ; MOURÃO, M. M. ; COELHO, F. S. ; FANTAPPIE, M. R. . Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni. PLoS Neglected Tropical Diseases, v. 14, p. e0008332, 2020.

4.
COELHO, FERNANDA SALES ; RODPAI, RUTCHANEE ; MILLER, ANDRÉ ; KARINSHAK, SHANNON E. ; MANN, VICTORIA H. ; DOS SANTOS CARVALHO, OMAR ; CALDEIRA, ROBERTA LIMA ; de Moraes Mourão, Marina ; BRINDLEY, PAUL J. ; ITTIPRASERT, WANNAPORN . Diminished adherence of Biomphalaria glabrata embryonic cell line to sporocysts of Schistosoma mansoni following programmed knockout of the allograft inflammatory factor. Parasites & Vectors, v. 13, p. 511, 2020.

5.
FERREIRA, J. G. G. ; GAVA, S. G. ; OLIVEIRA, E. S. ; Batista, I. C. A. ; FERNANDES, G. R. ; MOURÃO, M. M. ; CALZAVARA-SILVA, C. E. . Gene expression signatures in AML-12 hepatocytes cells upon DENV infection and APAP treatment. Viruses-Basel, v. 12, p. 1284, 2020.

6.
GAVA, S. G. ; AVELAR, L. G. A. ; NEVES, R. H. ; SILVA, M. ; ARAUJO, NEUSA ; PAULA, N. C. C. S. T. ; EL KHAL, A. ; Mattos, A C ; MACHADO-SILVA, J. R. ; OLIVEIRA, G. C. ; MOURÃO, M. M. . Smp38 MAP Kinase Regulation in Schistosoma mansoni: Roles in Survival, Oviposition, and Protection Against Oxidative Stress. Frontiers in Immunology, v. 10, p. 21, 2019.

7.
de MELO, T. T. ; MENDES, M. M. ; ALVES, C. C. ; CARVALHO, G. B. ; FERNANDES, V. C. ; PIMENTA, D. L. F. ; MOURÃO, M. M. ; GAI, F. ; KALLI, M. ; COELHO, A. ; DE AZAMBUJA RIBEIRO, R.I.M. ; FALCONE, F. ; PEREIRA, R. A. S. ; FONSECA, C. T. . The Schistosoma mansoni cyclophilin A epitope 107-121 induces a protective immune response against schistosomiasis. MOLECULAR IMMUNOLOGY, v. 111, p. 172-181, 2019.

8.
GAVA, S. G. ; PAULA, N. C. C. S. T. ; FALCONE, F. ; OLIVEIRA, G. C. ; MOURÃO, M. M. . Profiling transcriptional regulation and functional roles of Schistosoma mansoni c-Jun N-terminal kinase. Frontiers in Genetics, v. 10, p. 1036, 2019.

9.
BERNARDES, W. P. O. S. ; Araújo, J M ; CARVALHO, G. B. ; ALVES, C. C. ; COELHO, A. ; DUTRA, I. T. S. ; Texeira, S. S. F. ; DE AZAMBUJA RIBEIRO, R.I.M. ; MOURÃO, M. M. ; PEREIRA, R. A. S. ; FONSECA, C. T. . Sm16, a Schistosoma mansoni immunomodulatory protein, fails to elicit a protective immune response and does not have an essential role in parasite survival in the definitive host. Journal of Immunology Research, v. 2019, p. 6793596, 2019.

10.
MACCESI, M. ; AGUIAR, P. H. N. ; PASCHE, V. ; PADILLA, M. ; SUZUKI, B. M. ; MONTEFUSCCO, S. ; ABAGYAN, R. ; KEISER, J. ; MOURÃO, M. M. ; CAFFREY, C. R. . Multi-center screening of the Pathogen Box collection for schistosomiasis drug discovery. Parasites & Vectors, v. 12, p. 493, 2019.

11.
CASTILLO, M. ; HUMPHRIES, J. ; MOURÃO, M. M. ; MARQUEZ, J. ; GONZALEZ, A. ; MONTELONGO, C. E. . Biomphalaria glabrata immunity: Post-genome advances. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, v. 19, p. 303672, 2019.

12.
BORONI, M. L. M. ; SAMMETH, M. ; GAVA, S. G. ; MACEDO, A. M. ; MACHADO, C. R. ; FRANCO, G. R. ; MOURÃO, M. M. . Landscape of the spliced leader trans-splicing mechanism in Schistosoma mansoni. Scientific Reports, v. 8, p. 8:3877, 2018.

13.
ANDERSON, L. ; GOMES, M. R. ; MOURÃO, M. M. ; ROMIER, C. ; PIERCE, R. J. ; VERJOVSKI, S. A. . Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoni. PLOS NEGLECTED TROPICAL DISEASES (ONLINE), v. 11, p. e0005539, 2017.

14.
GROSSI, S. G. ; PAULA, N. C. C. S. T. ; ARAUJO, F. M. G. ; SALIM, A. C. ; OLIVEIRA, G. C. ; MOURÃO, M. M. . Schistosoma mansoni: Off-target analyses using nonspecific double-stranded RNAs as control for RNAi experiments in schistosomula. EXPERIMENTAL PARASITOLOGY, v. 5, p. e7, 2017.

15.
SCHOLTE, LARISSA L.S. ; Mourão, Marina M. ; PAIS, FABIANO SVIATOPOLK-MIRSKY ; MELESINA, JELENA ; ROBAA, DINA ; VOLPINI, ANGELA C. ; SIPPL, WOLFGANG ; PIERCE, RAYMOND J. ; OLIVEIRA, GUILHERME ; NAHUM, LAILA A. . Evolutionary relationships among protein lysine deacetylases of parasites causing neglected diseases. INFECTION GENETICS AND EVOLUTION, v. 5, p. S15671348173016, 2017.

16.
AGUIAR, P. H. N. ; FERNANDES, N. M. G. S. ; ZANI, C. L. ; MOURÃO, M. M. . A High Throughput colorimetric assay for detection of Schistosoma mansoni viability based on the tetrazolium salt XTT. Parasites & Vectors, v. 10, p. 1, 2017.

17.
MOURÃO, M. M.; GAVA, S. G. . RNA Interference and Nonspecific Controls in Parasitic Helminths. JOURNAL OF BACTERIOLOGY & PARASITOLOGY, v. 8, p. 1000325, 2017.

18.
PALEVICH, NIKOLA ; BRITTON, COLLETTE ; KAMENETZKY, LAURA ; MITREVA, MAKEDONKA ; de Moraes Mourão, Marina ; BENNURU, SASISEKHAR ; QUACK, THOMAS ; SCHOLTE, LARISSA LOPES SILVA ; TYAGI, RAHUL ; SLATKO, BARTON E. . Tackling Hypotheticals in Helminth Genomes. TRENDS IN PARASITOLOGY, v. 34, p. 179-183, 2017.

19.
GIAROLA-SILVA, S. ; COELHO-DOS-REIS, J. J. A. ; MOURÃO, M. M. ; NAKAGAKI-SILVA, E. E. ; SANTOS, S. M. E. ; PERUHYPE-MAGALHAES, V. ; TEIXEIRA de CARVALHO, A. ; MARTINS-FILHO, O. A. ; ARAUJO, M. S. S. . Distinct patterns of cellular immune response elicited by influenza non-adjuvanted and AS03-adjuvanted monovalent H1N1(pdm09) vaccine. ANTIVIRAL RESEARCH, v. 5, p. S01663542173000, 2017.

20.
ANDRADE, LUIZA FREIRE DE ; Mourão, Marina de Moraes ; GERALDO, JULIANA ASSIS ; COELHO, FERNANDA SALES ; SILVA, LARISSA LOPES ; NEVES, RENATA HEISLER ; VOLPINI, ANGELA ; MACHADO-SILVA, JOSÉ ROBERTO ; ARAUJO, NEUSA ; NACIF-PIMENTA, RAFAEL ; CAFFREY, CONOR R. ; OLIVEIRA, GUILHERME . Regulation of Schistosoma mansoni Development and Reproduction by the Mitogen-Activated Protein Kinase Signaling Pathway. PLOS NEGLECTED TROPICAL DISEASES (ONLINE), v. 8, p. e2949, 2014.

21.
CABRAL, M. ; SILVA, F. R. ; GOMES, L. I. ; ZAULI, D. A. G. ; MOURÃO, M. M. ; TEIXEIRA de CARVALHO, A. ; MARTINS-FILHO, O. A. . Impact of mitomycin C on the mRNA expression signatures of immunological biomarkers in eosinophilic nasal polyposis. American Journal of Rhinology & Allergy (Print), v. 27, p. 32-41, 2013.

22.
MOURÃO, M. M.; BITAR, M. ; LOBO, F. P. ; GRYNBERG, P. ; WAISBERG, M. ; PROSDOCIMI, F. ; MACHADO, C. R. ; MACEDO, A. M. ; YOSHINO, T. P. ; FRANCO, G. R. . A directed approach for the identification of transcripts harbouring the spliced leader sequence and the effect of trans-splicing knockdown in Schistosoma mansoni. Memórias do Instituto Oswaldo Cruz (Impresso), v. 108, p. 707-717, 2013.

23.
MAREK, M. ; KANNAN, S. ; HAUSER, A. T. ; MOURÃO, M. M. ; CABY, S. ; CURA, V. ; STOLFA, D. A. ; SCHMIDTKUNZ, K. ; ANDRADE, L. F. ; RENAUD, J. ; OLIVEIRA, G. C. ; SIPPL, W. ; JUNG, M. ; CAVARELLI, J. ; PIERCE, R. J. ; ROMIER, C. . Structural Basis for the Inhibition of Histone Deacetylase 8 (HDAC8), a Key Epigenetic Player in the Blood Fluke Schistosoma mansoni. PLoS Pathogens (Online), v. 9, p. e1003645, 2013.

24.
GRYNBERG, P. ; PASSOS-SILVA, D. G. ; Mourão, Marina de Moraes ; HIRATA, R. J. ; MACEDO, A. M. ; MACHADO, C. R. ; BARTHOLOMEU, D. C. ; FRANCO, G. R. . Trypanosoma cruzi Gene Expression in Response to Gamma Radiation. Plos One, v. 7, p. e29596, 2012.

25.
NAHUM, L. A. ; MOURÃO, M. M. ; OLIVEIRA, G. C. . New Frontiers in Schistosoma Genomics and Transcriptomics. Journal of Parasitology Research (Print), v. 2012, p. 1-11, 2012.

26.
MOURÃO, M. M.; GRUNAU, C. ; JONES, M. ; LOVERDE, P. T. ; OLIVEIRA, G. C. . Recent advances in Schistosoma genomics. PARASITE IMMUNOL., v. 34, p. 151-162, 2012.

27.
LACERDA, I. C. A. ; GOMES, F. C. O. ; BORELLI, B. M. ; FARIA JUNIOR, C. ; FRANCO, G. R. ; MOURÃO, M. M. ; MORAIS, P. B. ; ROSA, C. A. . Identification of the Bacterial Community Responsible for Tradirional Fermentation During Sour Cassava Startch, Cachaça and Minas Cheese Production Using Culture Independent 16S rRNA Gene Sequence Analysis. Brazilian Journal of Microbiology (Impresso), v. 42, p. 650-657, 2011.

28.
GOMES, F. C. O. ; SILVA, C. L. C. ; VIANNA, C. R. ; LACERDA, I. C. A. ; BORELLI, B. M. ; NUNES, A. C. ; FRANCO, G. R. ; MOURÃO, M. M. ; ROSA, C. A. . Identification of lactic acid bacteria associated with traditional cachaça fermentations. Brazilian Journal of Microbiology (Impresso), v. 41, p. 486-492, 2010.

29.
ABREU, J. T. ; MOURÃO, M. M. ; SANTOS, C. E. ; VELOSO, C. J. M. ; RESENDE, J. S. ; FLATSCHART, R. B. ; FOLGUERAS-FLATSCHART, A. V. ; JÚNIOR, S. N. ; SANTORO, M. M. ; MENDES, A. C. R. ; FRANCO, G. R. ; SILVA, A. ; CAMPOS, A. B. ; FERNANDEZ, S. . Molecular Studies of the Brazilian Infectious Bronchitis Virus Isolates. Revista Brasileira de Ciência Avícola / Brazilian Journal of Poultry Science, v. 12, p. 85-88, 2010.

30.
GREEN, V. A. ; MUNSHI, S. U. ; MARAKALALA, M. J. ; Mourão, Marina M. . Molecular mechanisms of viral infection and propagation: An overview of the second Advanced Summer School in Africa. IUBMB Life (London), v. 62, p. 573-583, 2010.

31.
MOURÃO, M. M.; DINGUIRARD, N. ; FRANCO, G. R. ; YOSHINO, T. P. . Phenotypic Screen of Early-Developing Larvae of the Blood Fluke, Schistosoma mansoni, using RNA Interference. Plos Neglected Tropical Diseases, v. 3, p. e502, 2009.

32.
Mourão, Marina de Moraes; DINGUIRARD, N. ; FRANCO, G. R. ; YOSHINO, T. P. . Role of the Endogenous Antioxidant System in the Protection of Schistosoma mansoni Primary Sporocysts against Exogenous Oxidative Stress. Plos Neglected Tropical Diseases, v. 3, p. e550, 2009.

33.
DRUMMOND, M. G. ; CALZAVARA-SILVA, C. E. ; D'ASTOLFO, D. S. ; CARDOSO, F. C. ; RAJAO, M. A. ; Mourão, Marina M. ; GAVA, E. ; OLIVEIRA, S. C. ; MACEDO, A. M. ; MACHADO, C. R. ; PENA, S. D. J. ; KITTEN, G. T. ; FRANCO, G. R. . Molecular Characterization of the Schistosoma mansoni Zinc Finger Protein SmZF1 as a Transcription Factor. PLoS Neglected Tropical Diseases (Online), v. 3, p. e547, 2009.

34.
YOSHINO, T. P. ; DINGUIRARD, N. ; de Moraes Mourão, Marina . In vitro manipulation of gene expression in larval Schistosoma: a model for postgenomic approaches in Trematoda. Parasitology (London. Print), p. 1-21, 2009.

35.
SANTOS, D. ; AGUIAR, P. H. N. ; LOBO, F. P. ; MOURAO, M ; TAMBOR, J. H. ; VALADAO, A. F. ; VILAS-BOAS, A. ; NOBREGA, F. ; LOVERDE, P. T. ; MACEDO, A. M. . Schistosoma mansoni: Heterologous complementation of a yeast null mutant by SmRbx, a protein similar to a RING box protein involved in ubiquitination?. Experimental Parasitology, v. 116, p. 440-449, 2007.

36.
PROSDOCIMI, F. ; LOPES, D. A. O. ; PEIXOTO, F. C. ; MOURÃO, M. M. ; PACÍFICO, L. G. ; RIBEIRO, R. A. ; ORTEGA, J. M. . Effects of sample re-sequencing and trimming on the quality and size of assembled consensus sequences. Genetics and Molecular Research, v. 6, p. 756-765, 2007.

Book Chapters
1.
PAULA, N. C. C. S. T. ; AGUIAR, P. H. N. ; GROSSI, S. G. ; OLIVEIRA, G. C. ; MOURÃO, M. M. . DRUG DISCOVERY- Schistosomiasis: Setting routes for drug discovery. 1. ed. Rijeka: Intech Open Science, 2016. v. 1.
2.
GAVA, S. G. ; SILVA JUNIOR, F. P. ; MOURÃO, M. M. ; SENGER, M. R. ; CALDEIRA, R. L. ; ROCHA, R. S. . Fármacos anti-helmínticos. In: Paulo Caleb Júnior de Lima Santos; Adriana Castello Costa Girardi; Fábio Cardoso Cruz; Gustavo José da Silva Pereira. (Org.). Farmacologia-Brazilian Institute of Pratical Pharmacology. 1ed.Rio de Janeiro: Atheneu, 2021, v. 1, p. 841-854.
3.
SANTOS, C. E. ; DIAS, M. C. ; MOURÃO, M. M. ; RESENDE, J. S. ; MACHADO, C. R. ; MACEDO, A. M. ; ABREU, J. T. ; FRANCO, G. R. . EVALUATING GENETIC VARIABILITY OF AVIAN INFECTIOUS BRONCHITIS VIRUS BRAZILIAN SOUTHEAST ISOLATES AND ASSESSING LSSP-PCR PATTERNS FOR DIAGNOSTIC TOOLS DEVELOPMENT. In: Prof. Dr. Michael Lierz ; Dr. Ursula Heffels-Redmann; Prof. Dr. Erhard F. Kaleta; Julia Heckmann. (Org.). Proceeding International Symposium on Avian Corona- and Pnumoviruses and Complicating Pathogens. 1ed.Wetter: Druckerei Schröder, 2012, v. VII, p. 31-42.
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