Reviewer
Xinlei Li
  • Research scientist, The Abigail Wexner Research Institute at Nationwide Children's Hospital
Research focus
  • Cell biology
  • non-alcoholic steatohepatitis pathogenesis mechanisms; extracellular vesicle-based potential therapeutic for liver diseases; hepatitis virology.

Education

PhD, University of Chinese Academy of Sciences, 2014

Lab information

David Brigstock lab focuses on the extracellular vesicles-based interplays between parenchymal and non-parenchymal cells in the liver, and potential therapeutic against liver diseases including fibrosis, alcoholic liver disease, and non-alcoholic steatohepatitis.

Publications

1. Li, Xinlei, Jinqian Li, Yetong Feng, Hua Cai, Yi-Ping Li, Tao Peng. Long-chain fatty acyl-coenzyme A suppresses hepatitis C virus infection by targeting virion-bound lipoproteins. Antiviral Research, 2020. 177: 104734.
2. Li, Xinlei, Ruju Chen, Sherri Kemper, and David R. Brigstock. Dynamic changes in function and proteomic composition of extracellular vesicles from hepatic stellate cells during cellular activation. Cells, 2020. 9(2), 290.
3. Li, Xinlei#, Ruju Chen#, Sherri Kemper, and David R. Brigstock. Extracellular Vesicles from Hepatocytes Are Therapeutic for Toxin-Mediated Fibrosis and Gene Expression in the Liver. Frontiers in Cell and Developmental Biology, 2020. 7(368). https://dx.doi.org/10.3389/fcell.2019.00368. (#co-first author)
4. Liu, Chang, Wei Cai, Xin Yin, Zimin Tang, Guiping Wen, Charuta Ambardekar, Xinlei Li, Dong Ying, Zongdi Feng, Zizheng Zheng, and Ningshao Xia. An Optimized High-Throughput Neutralization Assay for Hepatitis E Virus (HEV) Involving Detection of Secreted Porf2. Viruses, 2019. 11(1).
5. Yin, Xin, Xinlei Li, Charuta Ambardekar, Zhimin Hu, Sebastien Lhomme, and Zongdi Feng. Hepatitis E virus persists in the presence of a type III interferon response. PLoS pathogens, 2017. 13(5): e1006417.
6. Yin, Xin, Xinlei Li, and Zongdi Feng. Role of Envelopment in the HEV Life Cycle. Viruses, 2016. 8(8).
7. Cai, Hua, Wenxia Yao, Leike Li, Xinlei Li, Longbo Hu, Ruiming Mai, and Tao Peng. Cell-death-inducing DFFA-like Effector B Contributes to the Assembly of Hepatitis C Virus (HCV) Particles and Interacts with HCV NS5A. Scientific reports, 2016. 6: 27778.
8. Li, Xinlei, Rong Zhou, Tao Peng (2015). The current progress in the development of hepatitis C virus cell culture systems. Chin J Viral Dis. 5(1):58-66.
李新磊,周荣,彭涛(2015)。丙型肝炎病毒体外细胞培养系统研究进展。中国病毒病杂志,5(1):58-66
9. Yao, Wenxia#, Hua Cai#, Xinlei Li, Ting Li, Longbo Hu and Tao Peng (2014). Endoplasmic reticulum stress links hepatitis C virus RNA replication to WT-PGC-1α/L-PGC-1α upregulation. J. Virol. 88(15):8361-74. (#co-first author)
10. Li, Xinlei#, Hanfang Jiang#, Linbing Qu, Wenxia Yao, Hua Cai, Ling Chen and Tao Peng (2014). Hepatocyte Nuclear Factor 4α and Downstream Secreted Phospholipase A2 GXIIB Regulate Production of Infectious Hepatitis C Virus. J Virol 88(1): 612-627. DOI: 10.1128/JVI.02068-13. (#co-first author)
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