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A peer-reviewed protocol journal. No publication fee; no access fee.
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Lin Guo
Biochemistry and Molecular Biology, Thomas Jefferson University, 2019-
1 protocol
Emma Robinson
Department of Biochemistry and Molecular Biology, Thomas Jefferson University, 2019-2020
1 protocol
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James Shorter
Professor, Biochemistry & Biophysics, University of Pennsylvania
Research focus
Biochemistry
Contributions
1
Author merit
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Education
Ph.D., University of London, U.K.
Publications
https://www.med.upenn.edu/shorterlab/publications.html
1 Protocol published
Karyopherin-β2 Inhibits and Reverses Aggregation and Liquid-liquid Phase Separation of the ALS/FTD-Associated Protein FUS
Authors:
Emma Robinson
,
James Shorter
and
Lin Guo
,
date:
08/20/2020,
view:
754,
Q&A:
0
The study of RNA-binding proteins (RBP) offers insight into the mechanisms of pathologic protein aggregation in neurodegenerative diseases. We developed a protocol for purifying an RBP FUS and a nuclear import receptor (NIR) Kapβ2 and testing the ...
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