Fangliang Zhang Mol & Cell Pharmacology, University of Miami, Miller School of Medicine, USA, 2012-
1 protocol

Lauren Lotenfoe Biology, University of Miami, 2016-
1 protocol

Balaji Moorthy Molecular and Cellular Pharmacology, University of Miami, 2015-
1 protocol

Akhilesh Kumar
  • Assistant Professor, Department of Botany, Banaras Hindu University, India, 2018-2020
Research focus
  • -
  • 1 Author merit

Education

PhD, IMTECH, Chandigarh (JNU), India, 2012

Publications

• Kumar, A., Birnbaum, M. D., Moorthy, B. T., Singh, J., Palovcak, A., Patel, D. M. and Zhang, F. (2019). Insertion/deletion-activated frame-shift fluorescence protein is a sensitive reporter for genomic DNA editing. BMC Genomics 20(1): 609.
• Birnbaum, M. D., Zhao, N., Moorthy, B. T., Patel, D. M., Kryvenko, O. N., Heidman, L., Kumar, A., Morgan, W. M., Ban, Y., Reis, I. M., Chen, X., Gonzalgo, M. L., Jorda, M., Burnstein, K. L. and Zhang, F. (2019). Reduced Arginyltransferase 1 is a driver and a potential prognostic indicator of prostate cancer metastasis. Oncogene 38(6): 838-851.
• Kingsbury, C., Heyck, M., Bonsack, B., Lee, J. Y. and Borlongan, C. V. (2020). Stroke gets in your eyes: stroke-induced retinal ischemia and the potential of stem cell therapy. Neural Regen Res 15(6): 1014-1018.
• Birnbaum, M. D., Nemzow, L., Kumar, A., Gong, F. and Zhang, F. (2018). A Rapid and Precise Mutation-Activated Fluorescence Reporter for Analyzing Acute Mutagenesis Frequency. Cell Chem Biol 25(8): 1038-1049 e1035.
• Kaur, A., Gautam, R., Srivastava, R., Chandel, A., Kumar, A., Karthikeyan, S. and Bachhawat, A. K. (2017). ChaC2, an Enzyme for Slow Turnover of Cytosolic Glutathione. J Biol Chem 292(2): 638-651.
• Kumar, A., Birnbaum, M. D., Patel, D. M., Morgan, W. M., Singh, J., Barrientos, A. and Zhang, F. (2016). Posttranslational arginylation enzyme Ate1 affects DNA mutagenesis by regulating stress response. Cell Death Dis 7(9): e2378.
• Rai, R., Zhang, F., Colavita, K., Leu, N. A., Kurosaka, S., Kumar, A., Birnbaum, M. D., Gyorffy, B., Dong, D. W., Shtutman, M. and Kashina, A. (2016). Arginyltransferase suppresses cell tumorigenic potential and inversely correlates with metastases in human cancers. Oncogene 35(31): 4058-4068.
• Chavez, J. D., Eng, J. K., Schweppe, D. K., Cilia, M., Rivera, K., Zhong, X., Wu, X., Allen, T., Khurgel, M., Kumar, A., Lampropoulos, A., Larsson, M., Maity, S., Morozov, Y., Pathmasiri, W., Perez-Neut, M., Pineyro-Ruiz, C., Polina, E., Post, S., Rider, M., Tokmina-Roszyk, D., Tyson, K., Vieira Parrine Sant'Ana, D. and Bruce, J. E. (2016). A General Method for Targeted Quantitative Cross-Linking Mass Spectrometry. PLoS One 11(12): e0167547.
• Zhang, F., Patel, D. M., Colavita, K., Rodionova, I., Buckley, B., Scott, D. A., Kumar, A., Shabalina, S. A., Saha, S., Chernov, M., Osterman, A. L. and Kashina, A. (2015). Arginylation regulates purine nucleotide biosynthesis by enhancing the activity of phosphoribosyl pyrophosphate synthase. Nat Commun 6: 7517.
• Calpena, E., Deshpande, A. A., Yap, S., Kumar, A., Manning, N. J., Bachhawat, A. K. and Espinos, C. (2015). New insights into the genetics of 5-oxoprolinase deficiency and further evidence that it is a benign biochemical condition. Eur J Pediatr 174(3): 407-411.
• Kumar, A., Tikoo, S., Maity, S., Sengupta, S., Sengupta, S., Kaur, A. and Bachhawat, A. K. (2012). Mammalian proapoptotic factor ChaC1 and its homologues function as gamma-glutamyl cyclotransferases acting specifically on glutathione. EMBO Rep 13(12): 1095-1101.
• Kumar, A. and Bachhawat, A. K. (2012). Pyroglutamic acid: throwing light on a lightly studied metabolite. Current Science 102 (2): 288-297.
• Kumar, A. and Bachhawat, A. K. (2010). OXP1/YKL215c encodes an ATP-dependent 5-oxoprolinase in Saccharomyces cerevisiae: functional characterization, domain structure and identification of actin-like ATP-binding motifs in eukaryotic 5-oxoprolinases. FEMS Yeast Res 10(4): 394-401.
• Kumar, A. and Bachhawat, A. K. (2010). A futile cycle, formed between two ATP-dependant gamma-glutamyl cycle enzymes, gamma-glutamyl cysteine synthetase and 5-oxoprolinase: the cause of cellular ATP depletion in nephrotic cystinosis? J Biosci 35(1): 21-25.
1 Protocol published
Evaluation of the Efficiency of Genome Editing Tools by a Frameshift Fluorescence Protein Reporter
Authors:  Balaji T. Moorthy, Akhilesh Kumar, Lauren X. Lotenfoe and Fangliang Zhang, date: 05/20/2020, view: 1450, Q&A: 0
In the last decade, genome editing has been the center of attention as a novel tool for mechanistic investigations and for potential clinical applications. Various genome editing tools like meganucleases, zinc finger nucleases (ZFNs), transcription ...
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