Alan Armstrong Department of Chemistry Imperial College London
1 protocol

Gregory Craven Chemical Biology University of Leeds
1 protocol

David Julian Mann
  • Dr, Life Sciences Imperial College London
Research focus
  • Molecular biology
  • 1 Author merit

Education

PhD, University of Sheffield

Publications

https://scholar.google.com/citations?hl=en&user=auzTblAAAAAJ&scilu=&scisig=AMD79ooAAAAAX46eB550ss39_kZIj41KrxHEuR4XrU2d&gmla=AJsN-F7K-QscgVX6hDeD89vASFxY8PCZcLg5Ws-BvCRKptnplXuLnT2hoqtxhDT2wV4qcI56XwngJRfxvTg1Xb4FVaUbrV99Z0Q7DPcaaXHm8cKLfMy9_WY&sciund=5114259669066401157
1 Protocol published
Quantitative Irreversible Tethering (qIT) for Target-directed Covalent Fragment Screening
Authors:  Gregory B. Craven, David J. Mann and Alan Armstrong, date: 12/20/2020, view: 490, Q&A: 0

Small molecules that react to form covalent bonds with proteins are widely used as biological tools and therapeutic agents. Screening cysteine-reactive fragments against a protein target is an efficient way to identify chemical starting points for

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