Xin Xu Pharmacology and Toxicology, Augusta University, USA, 2018-2020
1 protocol

Guangyu Wu
  • Professor, Pharmacology and Toxicology, Medical College of Georgia
Research focus
  • Cell biology
  • 1 Author merit

Education

PhD, Peking Union Medical College , China

Publications

Since 2015
1. Naughton SX, Beck WD, Wei Z, Wu G and Terry AV Jr. Multifunctional compounds Lithium Chloride and Methylene Blue attenuate the negative effects of diisopropylfluorophosphate on axonal transport in rat cortical neurons. Toxicology 431:152379 (2020)
2. Livingston M, Wang J, Zhou J, Wu G, Ganley I, Hill J, Yin XM and Dong Z. Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys. Autophagy 15(12):2142-2162 (2019)
3. Du RH, Lu M, Wang C, Ding JH, Wu G and Hu G. The pore-forming subunit Kir6.1 of the K-ATP channel negatively regulates the NLRP3 inflammasome to control insulin resistance by interacting with NLRP3. Exp Mol Med 51(8):92 (2019)
4. Zhang M, Xu X, Li C, Huang W, Xu N, and Wu G. A naturally occurring splice variant of GGA1 inhibits the anterograde post-Golgi traffic of 2B-adrenergic receptor. Sci Rep 9:10378 (2019)
5. Wei Z, Zhang M, Li C, Huang W, Fan Y, Guo J, Fukuda M, Dong Z, Hu G and Wu G. Specific TBC domain-containing proteins control the ER-Golgi-plasma membrane trafficking of GPCRs. Cell Rep 28(2):554-566 (2019)
6. Li ZW, Sun B, Gong T, Guo S, Zhang J, Wang J, Sugawara A, Jiang M, Yan J, Gurary A, Zheng X, Gao B, Xiao SY, Chen W, Ma C, Farrar C, Zhu C, Chan OTM, Xin C, Winnicki A, Winnicki J, Tang M, Park R, Winnicki M, Diener K, Wang Z, Liu Q, Chu CH, Arter ZL, Yue P, Alpert L, Hui GS, Fei P, Turkson J, Yang W, Wu G, Tao A, Ramos JW, Moisyadi S, Holcombe RF, Jia W, Birnbaumer L, Zhou X, Chu WM. GNAI1 and GNAI3 reduce colitis-associated tumorigenesis in mice by blocking IL6 signaling and downregulating expression of GNAI. Gastroenterology 156(8):2297-2312 (2019)
7. Zhang Y, Wang L, Lv Y, Jiang C, Wu G, Dull RO, Minshall RD, Malik AB and Hu G. The GTPase Rab1 is required for NLRP3 inflammasome activation and inflammatory lung injury. J Immunol 202(1):194-206 (2019).
8. Zhang M and Wu G. Mechanisms of the anterograde trafficking of GPCRs: Regulation of AT1R transport by interacting proteins and motifs. Traffic 20(2):110-120 (2019)
9. Wang G, Wei Z and Wu G. Role of Rab GTPases in the export trafficking of G protein-coupled receptors. Small GTPases 9(1-2):130-135 (2018)
10. Dong W, He B, Qian H, Liu Q, Wang D, Li J, Wei Z, Wang Z, Xu Z, Wu G, Qian G and Wang G. RAB26-dependent autophagy protects adherens junctional integrity in acute lung injury. Autophagy 14(10):1677-1692 (2018)
11. Wei Z, Wu G and Chen BS. Regulation of SAP102 synaptic targeting by phosphorylation. Mol Neurobiol 55(8):6215-6226 (2018)
12. Wang S, Liu A, Wu G, Ding HF, Huang S, Nahman S and Dong Z. The CPLANE protein Intu protects kidneys from ischemia-reperfusion injury by targeting STAT1 for degradation. Nat Commun 9(1):1234 (2018)
13. Liu J, Livingston MJ, Dong G, Tang C, Su Y, Wu G, Yin XM and Dong Z. Histone deacetylase inhibitors protect against cisplatin-induced acute kidney injury by activating autophagy in proximal tubular cells. Cell Death Dis 9(3):322 (2018)
14. Li C, Wei Z, Fan Y, Huang W, Su Y, Li H, Dong Z, Fukuda M, Khater M and Wu G. The GTPase Rab43 controls the anterograde ER-Golgi trafficking and sorting of GPCRs. Cell Rep 21(4):1089- 1101 (2017)
15. Czikora I, Alli AA, Sridhar S, Matthay MA, Pillich H, Hudel M, Berisha B, Gorshkov B, Romero MJ, Gonzales J, Wu G, Huo Y, Su Y, Verin AD, Fulton D, Chakraborty T, Eaton DC and Lucas R. ENaC-alphaα mediates the protective effect of the TNF-derived TIP peptide in pneumolysin- induced endothelial barrier dysfunction. Front Immunol 8:842 (2017)
16. Gao G, Naughton SX, Beck WD, Hernandez CM, Wu G, Wei Z, Yang X, Bartlett MG and Terry AV Jr. Chlorpyrifos and chlorpyrifos oxon impair the transport of membrane bound organelles in rat cortical axons. Neurotoxicology 62:111-123 (2017).
17. Cai PC, Kovacs L, Dong S, Wu G and Su Y. BMP4 inhibits PDGF-induced proliferation and collagen synthesis via PKA-mediated inhibition of calpain-2 in pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 312(5):L638-L648 (2017)
18. Hao J, Lou Q, Wei Q, Mei S, Li L, Wu G, Mi QS, Mei C, Dong Z. MicroRNA-375 is induced in cisplatin nephrotoxicity to repress hepatocyte nuclear factor 1-beta. J Biol Chem 292(11):4571- 4582 (2017)
19. Zhang M, Huang W, Gao J, Terry AV Jr and Wu G. Regulation of α2B-adrenergic receptor cell surface transport by GGA1 and GGA2. Sci Rep 6:37921 (2016)
20. Xie X, Tang SC, Cai Y, Pi W, Deng L, Wu G, Chavanieu A, Teng Y. Suppression of breast cancer metastasis through the inactivation of ADP-ribosylation factor 1. Oncotarget 7(36):58111-58120 (2016)
21. Du RH, Wu FF, Lu M, Shu XD, Ding JH, Wu G and Hu G. Uncoupling protein 2 modulation of the NLRP3 inflammasome in astrocytes and its implications in depression. Redox Biol 9:178-187 (2016)
22. Davis JE, Guo J, Huang W, Huang S, Chu WM, Teng Y and Wu G. ARF1 promotes prostate tumorigenesis via targeting oncogenic MAPK signaling. Oncotarget 7(26):39834-39845 (2016)
23. Zhang M, Davis JE, Li C, Gao J, Huang W, Lambert NA, Terry AV Jr. and Wu G. GGA3 interacts with a G protein-coupled receptor and modulates its cell surface export. Mol Cell Biol 36(7):1152- 1163 (2016)
24. Zhu S, Zhang M, Davis JE, Wu WH, Surrao K, Wang H, Wu G. A single mutation in helix 8 enhances the angiotensin II type 1a receptor transport and signaling. Cell Signal 27(12):2371- 2379 (2015).
25. Yang J, Yao W, Qian G, Wei Z, Wu G and Wang G. Rab5-mediated VE-cadherin internalization regulates lung microvascular endothelial barrier function. Cell Mol Life Sci 72(24):4849-4866 (2015).
26. Lan T, Wu G and Lambert NA. Lateral diffusion contributes to FRET from lanthanide-tagged membrane proteins. Biochem Biophys Res Commun 464(1):244-248 (2015)
27. Zhou F, Dong C, Davis JE, Wu WH, Surrao H and Wu G. The mechanism of function of mitogen- activation protein kinase activation by ARF1. Cell Signal 27(10):2035-2044 (2015)
28. Yang J, Sun H, Zhang J, Hu M, Wang J, Wu G and Wang G. Regulation of -adrenergic receptor trafficking and lung microvascular endothelial cell permeability by Rab5 GTPase. Int J Biol Sci 11(8):868-878 (2015)
29. Wu G, Davis JE and Zhang M. Regulation of 2B-adrenerigc receptor export trafficking by specific motifs. Prog Mol Biol Transl Sci: Trafficking of GPCRs (edited by Guangyu Wu) 132:227-244 (2015)
30. Lan T, Liu Q, Li C, Wu G, Steyaert J and Lambert NA. BRET evidence that 2 adrenergic receptors do not oligomerize in cells. Sci Rep 5:10166 (2015)
31. Jang JH, Chun JN, Godo S, Wu G, Shimokawa H, Jin CZ, Jeon JH, Kim SJ, Jin ZH, Zhang YH. ROS and endothelial nitric oxide synthase (eNOS)-dependent trafficking of angiotensin II type 2 receptor begets neuronal NOS in cardiac myocytes. Basic Res Cardiol 110(3):477 (2015)
1 Protocol published
Quantification of the Surface Expression of G Protein-coupled Receptors Using Intact Live-cell Radioligand Binding Assays
Authors:  Xin Xu and Guangyu Wu, date: 09/20/2020, view: 347, Q&A: 0
G protein-coupled receptors (GPCRs) are the most structurally diverse family of signaling proteins and regulate a variety of cell function. For most GPCRs, the cell surface is their functional destination where they are able to respond a wide range ...
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