I-Ping Chen
  • Associate Professor, Oral Health and Diagnostic Sciences University of Connecticut Health
Research focus
  • Cell biology
  • 1 Author merit

Education

PhD, University of Connecticut Health, 2009

Publications

1. Reichenberger E, Chen IP. (1993) Craniometaphyseal Dysplasia, Autosomal Dominant. Review. PubMed PMID: 20301634.
2. Chen IP, Karabucak B. (2006) Conventional and surgical endodontic retreatment of a maxillary first molar: unusual anatomy. J Endod. 32(3):228-30. doi: 10.1016/j.joen.2005.07.006. PubMed PMID: 16500233.
3. Chen IP, Wang CJ, Strecker S, Koczon-Jaremko B, Boskey A, Reichenberger EJ. (2009) Introduction of a Phe377del mutation in ANK creates a mouse model for craniometaphyseal dysplasia. J Bone Miner Res. 24(7):1206-15. doi: 10.1359/jbmr.090218. PubMed PMID: 19257826; PubMed Central PMCID: PMC2697624.
4. Wang CJ, Chen IP, Koczon-Jaremko B, Boskey AL, Ueki Y, Kuhn L, Reichenberger EJ. (2010) Pro416Arg cherubism mutation in Sh3bp2 knock-in mice affects osteoblasts and alters bone mineral and matrix properties. Bone. 46(5):1306-15. doi: 10.1016/j.bone.2010.01.380. PMID: 20117257; PMCID: PMC2854251.
5. Mukherjee PM, Wang CJ, Chen IP, Jafarov T, Olsen BR, Ueki Y, Reichenberger EJ. (2010) Cherubism gene Sh3bp2 is important for optimal bone formation, osteoblast differentiation, and function. Am J Orthod Dentofacial Orthop. 138(2):140.e1-140.e11; discussion 140-1. doi: 10.1016/j.ajodo.2009.05.021. PMID: 20691350; PMCID: PMC3268358.
6. Chen IP, Wang L, Jiang X, Aguila HL, Reichenberger EJ. (2011) A Phe377del mutation in ANK leads to impaired osteoblastogenesis and osteoclastogenesis in a mouse model for craniometaphyseal dysplasia (CMD). Hum Mol Genet. 20(5):948-61. doi: 10.1093/hmg/ddq541. PMID: 21149338; PMCID: PMC3033186.
7. Olaitan PB, Chen IP, Norris JE, Feinn R, Oluwatosin OM, Reichenberger EJ. (2011) Inhibitory activities of omega-3 Fatty acids and traditional african remedies on keloid fibroblasts. Wounds. 23(4):97-106. PMID: 24489452; PMCID: PMC3905615.
8. Dutra EH, Chen IP, McGregor TL, Ranells JD, Reichenberger EJ. (2012) Two novel large ANKH deletion mutations in sporadic cases with craniometaphyseal dysplasia. Clin Genet. 81(1):93-5. doi: 10.1111/j.1399-0004.2011.01700.x. PMID: 22150416; PMCID: PMC3417334.
9. Davoody A, Chen IP, Nanda R, Uribe F, Reichenberger EJ. (2012) Oculofaciocardiodental syndrome: a rare case and review of the literature. Cleft Palate Craniofac 49(5):e55-60. doi: 10.1597/10-256. PMID: 21740180; PMCID: PMC3354011.
10. Dutra EH, Chen IP, Reichenberger EJ. (2013) Dental abnormalities in a mouse model for craniometaphyseal dysplasia. J Dent Res. 92(2):173-9. doi: 10.1177/0022034512468157. PMID: 23160629; PMCID: PMC3545689.
11. Wang T, Wu H, Li Y, Szulwach KE, Lin L, Li X, Chen IP, Goldlust IS, Chamberlain SJ, Dodd A, Gong H, Ananiev G, Han JW, Yoon YS, Rudd MK, Yu M, Song CX, He C, Chang Q, Warren ST, Jin P. (2013) Subtelomeric hotspots of aberrant 5-hydroxymethylcytosine-mediated epigenetic modifications during reprogramming to pluripotency. Nat Cell Biol.15(6):700-11. doi: 10.1038/ncb2748. PMID: 23685628; PMCID: PMC3998089.
12. Kim Y, Chang SW, Lee JK, Chen IP, Kaufman B, Jiang J, Cha BY, Zhu Q, Safavi KE, Kum KY. (2013) A micro-computed tomography study of canal configuration of multiple-canalled mesiobuccal root of maxillary first molar. Clin Oral Investig. 17(6):1541-6. doi: 10.1007/s00784-012-0852-8. PMID: 23053704.
13. Hu Y, Chen IP, de Almeida S, Tiziani V, Do Amaral CM, Gowrishankar K, Passos-Bueno MR, Reichenberger EJ. (2013) A novel autosomal recessive GJA1 missense mutation linked to Craniometaphyseal dysplasia. PLoS One. 8(8):e73576. doi: 10.1371/journal.pone.0073576. eCollection 2013. PMID: 23951358; PMCID: PMC3741164.
14. Chen IP, Fukuda K, Fusaki N, Iida A, Hasegawa M, Lichtler A, Reichenberger EJ. (2013) Induced pluripotent stem cell reprogramming by integration-free Sendai virus vectors from peripheral blood of patients with craniometaphyseal dysplasia. Cell Reprogram.15(6):503-13. doi: 10.1089/cell.2013.0037. PMID: 24219578; PMCID: PMC3848480.
15. Chen IP, Tadinada A, Dutra EH, Utreja A, Uribe F, Reichenberger EJ. (2014) Dental Anomalies Associated with Craniometaphyseal Dysplasia. J Dent Res. 93(6):553-8. doi: 10.1177/0022034514529304. PMID: 24663682; PMCID: PMC4023465.
16. Chen IP. (2014) The Use of Patient-Specific Induced Pluripotent Stem Cells (iPSCs) to Identify Osteoclast Defects in Rare Genetic Bone Disorders. J Clin Med. 17;3(4):1490-510. doi: 10.3390/jcm3041490. PMID: 25621177; PMCID: PMC4300535.
17. Rifaey HS, Villa M, Zhu Q, Wang YH, Safavi K, Chen IP. (2016) Comparison of the Osteogenic Potential of Mineral Trioxide Aggregate and Endosequence Root Repair Material in a 3-dimensional Culture System. J Endod. 42(5):760-5. doi: 10.1016/j.joen.2016.02.001. PMID: 26994596.
18. Liu Y, Dutra EH, Reichenberger EJ, Chen IP. (2016) Dietary phosphate supplement does not rescue skeletal phenotype in a mouse model for craniometaphyseal dysplasia. J Negat Results Biomed. 15(1):18. doi: 10.1186/s12952-016-0061-0. PMID: 27784318; PMCID: PMC5080755.
19. Chhabra A, Chen IP, Batra D. (2017) Human Dendritic Cell-Derived Induced Pluripotent Stem Cell Lines Are Not Immunogenic. J Immunol. 198(5):1875-1886. doi: 10.4049/jimmunol.1601676. PMID: 28115528.
20. Chen IP, Luxmi R, Kanaujiya J, Hao Z, Reichenberger EJ. (2017) Craniometaphyseal Dysplasia Mutations in ANKH Negatively Affect Human Induced Pluripotent Stem Cell Differentiation into Osteoclasts. Stem Cell Reports. 9(5):1369-1376. doi: 10.1016/j.stemcr.2017.09.016. PMID: 29056330; PMCID: PMC5830990.
21. Granados JM, Rifaey H, Safari K, Tadinada A, Chen I. (2018) Conservative endodontic access – cone beam computed tomography (CBCT)-guided preparation and its impact on endodontic referrals. JSM Dentistry.
22. Liu Y, Sharma T, Chen IP, Reichenberger E, Ueki Y, Arif Y, Parisi D, Maye P. (2018) Rescue of a cherubism bone marrow stromal culture phenotype by reducing TGFβ signaling. Bone. 111:28-35. doi: 10.1016/j.bone.2018.03.009. PMID: 29530719; PMCID: PMC5924722.
23. Kanaujiya J, Bastow E, Luxmi R, Hao Z, Zattas D, Hochstrasser M, Reichenberger EJ, Chen IP. (2018) Rapid degradation of progressive ankylosis protein (ANKH) in craniometaphyseal dysplasia. Sci Rep. 8(1):15710. doi: 10.1038/s41598-018-34157-5. PMID: 30356088; PMCID: PMC6200807.
24. Curry EJ, Le TT, Das R, Ke K, Santorella EM, Paul D, Chorsi MT, Tran K, Baroody J, Borges ER, Ko B, Golabchi A, Xin X, Rowe D, Yue L, Feng J, Morales-Acosta D, Wu Q, Chen I, Cui T, Pachter J, Nguyen T. (2020) Biodegradable Nanofiber-Based Piezoelectric Transducer. PNAS. 117(1):214-220. Doi:10.1073/pnas.1910343117. PMID:31871178; PMCID: PMC6955346.
25. Fujii Y, Kozak E, Dutra E, Varadi A, Reichenberger EJ, Chen IP. (2020) Restriction of dietary phosphate ameliorates skeletal abnormalities in a mouse model for craniometaphyseal dysplasia. J Bone Miner Res. 35(10):2070-2081.
1 Protocol published
Differentiation of Human Induced Pluripotent Stem Cells (hiPSCs) into Osteoclasts
Author:  I-Ping Chen, date: 12/20/2020, view: 1786, Q&A: 0

Defects in bone resorption by osteoclasts result in numerous rare genetic bone disorders as well as in some common diseases such as osteoporosis or osteopetrosis. The use of hiPSC-differentiated osteoclasts opens new avenues in this research field

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