Natalie Sims St. Vincent's Institute of Medical Research Melbourne
2 protocols

Audrey Chan The University of Melbourne Melbourne
1 protocol

Narelle McGregor St. Vincent's Institute of Medical Research Melbourne
2 protocols

Ingrid Poulton 1 protocol

Emma C Walker
  • Research Assistant, Bone Biology, St Vincent's Institute, 2001-2020
Research focus
  • -
  • 2 Author merit


Honours, Deakin University , Australia, 2000


• McGregor, N. E., Murat, M., Elango, J., Poulton, I. J., Walker, E. C., Crimeen-Irwin, B., Ho, P. W. M., Gooi, J. H., Martin, T. J. and Sims, N. A. (2019). IL-6 exhibits both cis- and trans-signaling in osteocytes and osteoblasts, but only trans-signaling promotes bone formation and osteoclastogenesis. J Biol Chem 294(19): 7850-7863.
• Cho, D. C., Brennan, H. J., Johnson, R. W., Poulton, I. J., Gooi, J. H., Tonkin, B. A., McGregor, N. E., Walker, E. C., Handelsman, D. J., Martin, T. J. and Sims, N. A. (2017). Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6. Nat Commun 8(1): 806.
• Walker, E. C., Johnson, R. W., Hu, Y., Brennan, H. J., Poulton, I. J., Zhang, J. G., Jenkins, B. J., Smyth, G. K., Nicola, N. A. and Sims, N. A. (2016). Murine Oncostatin M Acts via Leukemia Inhibitory Factor Receptor to Phosphorylate Signal Transducer and Activator of Transcription 3 (STAT3) but Not STAT1, an Effect That Protects Bone Mass. J Biol Chem 291(41): 21703-21716.
• Johnson, R. W., White, J. D., Walker, E. C., Martin, T. J. and Sims, N. A. (2014). Myokines (muscle-derived cytokines and chemokines) including ciliary neurotrophic factor (CNTF) inhibit osteoblast differentiation. Bone 64: 47-56.
• Johnson, R. W., Brennan, H. J., Vrahnas, C., Poulton, I. J., McGregor, N. E., Standal, T., Walker, E. C., Koh, T. T., Nguyen, H., Walsh, N. C., Forwood, M. R., Martin, T. J. and Sims, N. A. (2014). The primary function of gp130 signaling in osteoblasts is to maintain bone formation and strength, rather than promote osteoclast formation. J Bone Miner Res 29(6): 1492-1505.
• Poulton, I. J., McGregor, N. E., Pompolo, S., Walker, E. C. and Sims, N. A. (2012). Contrasting roles of leukemia inhibitory factor in murine bone development and remodeling involve region-specific changes in vascularization. J Bone Miner Res 27(3): 586-595.
• Quach, J. M., Walker, E. C., Allan, E., Solano, M., Yokoyama, A., Kato, S., Sims, N. A., Gillespie, M. T. and Martin, T. J. (2011). Zinc finger protein 467 is a novel regulator of osteoblast and adipocyte commitment. J Biol Chem 286(6): 4186-4198.
• McGregor, N. E., Poulton, I. J., Walker, E. C., Pompolo, S., Quinn, J. M., Martin, T. J. and Sims, N. A. (2010). Ciliary neurotrophic factor inhibits bone formation and plays a sex-specific role in bone growth and remodeling. Calcif Tissue Int 86(3): 261-270.
• Walker, E. C., McGregor, N. E., Poulton, I. J., Solano, M., Pompolo, S., Fernandes, T. J., Constable, M. J., Nicholson, G. C., Zhang, J. G., Nicola, N. A., Gillespie, M. T., Martin, T. J. and Sims, N. A. (2010). Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice. J Clin Invest 120(2): 582-592.
• Quinn, J. M., Sims, N. A., Saleh, H., Mirosa, D., Thompson, K., Bouralexis, S., Walker, E. C., Martin, T. J. and Gillespie, M. T. (2008). IL-23 inhibits osteoclastogenesis indirectly through lymphocytes and is required for the maintenance of bone mass in mice. J Immunol 181(8): 5720-5729.
• Kartsogiannis, V., Sims, N. A., Quinn, J. M., Ly, C., Cipetic, M., Poulton, I. J., Walker, E. C., Saleh, H., McGregor, N. E., Wallace, M. E., Smyth, M. J., Martin, T. J., Zhou, H., Ng, K. W. and Gillespie, M. T. (2008). Osteoclast inhibitory lectin, an immune cell product that is required for normal bone physiology in vivo. J Biol Chem 283(45): 30850-30860.
• Walker, E. C., McGregor, N. E., Poulton, I. J., Pompolo, S., Allan, E. H., Quinn, J. M., Gillespie, M. T., Martin, T. J. and Sims, N. A. (2008). Cardiotrophin-1 is an osteoclast-derived stimulus of bone formation required for normal bone remodeling. J Bone Miner Res 23(12): 2025-2032.
• Udabage, L., Brownlee, G. R., Waltham, M., Blick, T., Walker, E. C., Heldin, P., Nilsson, S. K., Thompson, E. W. and Brown, T. J. (2005). Antisense-mediated suppression of hyaluronan synthase 2 inhibits the tumorigenesis and progression of breast cancer. Cancer Res 65(14): 6139-6150.
• Lafleur, M. A., Drew, A. F., de Sousa, E. L., Blick, T., Bills, M., Walker, E. C., Williams, E. D., Waltham, M. and Thompson, E. W. (2005). Upregulation of matrix metalloproteinases (MMPs) in breast cancer xenografts: a major induction of stromal MMP-13. Int J Cancer 114(4): 544-554.
• Tester, A. M., Waltham, M., Oh, S. J., Bae, S. N., Bills, M. M., Walker, E. C., Kern, F. G., Stetler-Stevenson, W. G., Lippman, M. E. and Thompson, E. W. (2004). Pro-matrix metalloproteinase-2 transfection increases orthotopic primary growth and experimental metastasis of MDA-MB-231 human breast cancer cells in nude mice. Cancer Res 64(2): 652-658.
2 Protocols published
Measuring Bone Volume at Multiple Densities by Micro-computed Tomography
Authors:  Emma C. Walker, Narelle E. McGregor, Audrey S. M. Chan and Natalie A. Sims, date: 01/05/2021, view: 1436, Q&A: 0

Bone strength is controlled by both bone mass, and the organization and quality of the bone material. The current standard method for measuring bone mass in mouse and rat studies is micro-computed tomography. This method typically uses a single

Testing Bone Formation Induction by Calvarial Injection Assay in vivo
Authors:  Narelle E McGregor, Ingrid J Poulton, Emma C Walker and Natalie A Sims, date: 03/20/2020, view: 2320, Q&A: 0
Bone formation occurs during embryogenesis, skeletal growth and during the process of skeletal renewal throughout life. In the process of bone formation, osteoblasts lay down a collagen-containing matrix, termed osteoid, which is gradually hardened ...
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