Natalie Sims St. Vincent's Institute of Medical Research
1 protocol

Emma Walker Bone Biology, St Vincent's Institute, 2001-2020
1 protocol

Ingrid Poulton 1 protocol

Narelle E McGregor
  • Snr Research Assistant, Bone Biology, St Vincent's Institute, 2006-2020
Research focus
  • -
  • 1 Author merit

Education

BSc., La Trobe University, Australia, 2006

Publications

• Cao, H., Cao, B., Heazlewood, C. K., Domingues, M., Sun, X., Debele, E., McGregor, N. E., Sims, N. A., Heazlewood, S. Y. and Nilsson, S. K. (2019). Osteopontin is An Important Regulative Component of the Fetal Bone Marrow Hematopoietic Stem Cell Niche. Cells 8(9).
• King, A., Hoch, N. C., McGregor, N. E., Sims, N. A., Smyth, I. M. and Heierhorst, J. (2019). Dynll1 is essential for development and promotes endochondral bone formation by regulating intraflagellar Dynein function in primary cilia. Hum Mol Genet.
• McGregor, N. E., Murat, M., Elango, J., Poulton, I. J., Walker, E. C., Crimeen-Irwin, B., Ho, P. W. M., Gooi, J. H., Martin, T. J. and Sims, N. A. (2019). IL-6 exhibits both cis- and trans-signaling in osteocytes and osteoblasts, but only trans-signaling promotes bone formation and osteoclastogenesis. J Biol Chem 294(19): 7850-7863.
• Tsantikos, E., Lau, M., Castelino, C. M., Maxwell, M. J., Passey, S. L., Hansen, M. J., McGregor, N. E., Sims, N. A., Steinfort, D. P., Irving, L. B., Anderson, G. P. and Hibbs, M. L. (2018). Granulocyte-CSF links destructive inflammation and comorbidities in obstructive lung disease. J Clin Invest 128(6): 2406-2418.
• Lazzaro, L., Tonkin, B. A., Poulton, I. J., McGregor, N. E., Ferlin, W. and Sims, N. A. (2018). IL-6 trans-signalling mediates trabecular, but not cortical, bone loss after ovariectomy. Bone 112: 120-127.
• Cho, D. C., Brennan, H. J., Johnson, R. W., Poulton, I. J., Gooi, J. H., Tonkin, B. A., McGregor, N. E., Walker, E. C., Handelsman, D. J., Martin, T. J. and Sims, N. A. (2017). Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6. Nat Commun 8(1): 806.
• Tonna, S., Poulton, I. J., Taykar, F., Ho, P. W., Tonkin, B., Crimeen-Irwin, B., Tatarczuch, L., McGregor, N. E., Mackie, E. J., Martin, T. J. and Sims, N. A. (2017). Correction: Chondrocytic ephrin B2 promotes cartilage destruction by osteoclasts in endochondral ossification. Development 144(3): 530.
• Tonna, S., Poulton, I. J., Taykar, F., Ho, P. W., Tonkin, B., Crimeen-Irwin, B., Tatarczuch, L., McGregor, N. E., Mackie, E. J., Martin, T. J. and Sims, N. A. (2016). Chondrocytic ephrin B2 promotes cartilage destruction by osteoclasts in endochondral ossification. Development 143(4): 648-657.
• Johnson, R. W., McGregor, N. E., Brennan, H. J., Crimeen-Irwin, B., Poulton, I. J., Martin, T. J. and Sims, N. A. (2015). Glycoprotein130 (Gp130)/interleukin-6 (IL-6) signalling in osteoclasts promotes bone formation in periosteal and trabecular bone. Bone 81: 343-351.
• Standal, T., Johnson, R. W., McGregor, N. E., Poulton, I. J., Ho, P. W., Martin, T. J. and Sims, N. A. (2014). gp130 in late osteoblasts and osteocytes is required for PTH-induced osteoblast differentiation. J Endocrinol 223(2): 181-190.
• Tonna, S., Takyar, F. M., Vrahnas, C., Crimeen-Irwin, B., Ho, P. W., Poulton, I. J., Brennan, H. J., McGregor, N. E., Allan, E. H., Nguyen, H., Forwood, M. R., Tatarczuch, L., Mackie, E. J., Martin, T. J. and Sims, N. A. (2014). EphrinB2 signaling in osteoblasts promotes bone mineralization by preventing apoptosis. FASEB J 28(10): 4482-4496.
• Johnson, R. W., Brennan, H. J., Vrahnas, C., Poulton, I. J., McGregor, N. E., Standal, T., Walker, E. C., Koh, T. T., Nguyen, H., Walsh, N. C., Forwood, M. R., Martin, T. J. and Sims, N. A. (2014). The primary function of gp130 signaling in osteoblasts is to maintain bone formation and strength, rather than promote osteoclast formation. J Bone Miner Res 29(6): 1492-1505.
• Walker, E. C., Poulton, I. J., McGregor, N. E., Ho, P. W., Allan, E. H., Quach, J. M., Martin, T. J. and Sims, N. A. (2012). Sustained RANKL response to parathyroid hormone in oncostatin M receptor-deficient osteoblasts converts anabolic treatment to a catabolic effect in vivo. J Bone Miner Res 27(4): 902-912.
• Poulton, I. J., McGregor, N. E., Pompolo, S., Walker, E. C. and Sims, N. A. (2012). Contrasting roles of leukemia inhibitory factor in murine bone development and remodeling involve region-specific changes in vascularization. J Bone Miner Res 27(3): 586-595.
• McGregor, N. E., Poulton, I. J., Walker, E. C., Pompolo, S., Quinn, J. M., Martin, T. J. and Sims, N. A. (2010). Ciliary neurotrophic factor inhibits bone formation and plays a sex-specific role in bone growth and remodeling. Calcif Tissue Int 86(3): 261-270.
• Walker, E. C., McGregor, N. E., Poulton, I. J., Solano, M., Pompolo, S., Fernandes, T. J., Constable, M. J., Nicholson, G. C., Zhang, J. G., Nicola, N. A., Gillespie, M. T., Martin, T. J. and Sims, N. A. (2010). Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice. J Clin Invest 120(2): 582-592.
• Quinn, J. M., Tam, S., Sims, N. A., Saleh, H., McGregor, N. E., Poulton, I. J., Scott, J. W., Gillespie, M. T., Kemp, B. E. and van Denderen, B. J. (2010). Germline deletion of AMP-activated protein kinase beta subunits reduces bone mass without altering osteoclast differentiation or function. FASEB J 24(1): 275-285.
• Kartsogiannis, V., Sims, N. A., Quinn, J. M., Ly, C., Cipetic, M., Poulton, I. J., Walker, E. C., Saleh, H., McGregor, N. E., Wallace, M. E., Smyth, M. J., Martin, T. J., Zhou, H., Ng, K. W. and Gillespie, M. T. (2008). Osteoclast inhibitory lectin, an immune cell product that is required for normal bone physiology in vivo. J Biol Chem 283(45): 30850-30860.
• Walker, E. C., McGregor, N. E., Poulton, I. J., Pompolo, S., Allan, E. H., Quinn, J. M., Gillespie, M. T., Martin, T. J. and Sims, N. A. (2008). Cardiotrophin-1 is an osteoclast-derived stimulus of bone formation required for normal bone remodeling. J Bone Miner Res 23(12): 2025-2032.
1 Protocol published
Testing Bone Formation Induction by Calvarial Injection Assay in vivo
Authors:  Narelle E McGregor, Ingrid J Poulton, Emma C Walker and Natalie A Sims, date: 03/20/2020, view: 561, Q&A: 0
Bone formation occurs during embryogenesis, skeletal growth and during the process of skeletal renewal throughout life. In the process of bone formation, osteoblasts lay down a collagen-containing matrix, termed osteoid, which is gradually hardened ...
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