Yan He
  • Professor, Department of Chemistry Tsinghua University
Research focus
  • Biophysics
  • 1 Author merit


Ph.D., Ph.D., 2001


1. J.-J. Feng, Z.-X. Zhang, X.-D. Wen, J.-F. Xue, Y. He, Single Nanoparticle Tracking Reveals Efficient Long-Distance Undercurrent Transport in Upper Fluid of Bacterial Swarms, iScience. 2019, 22, 123-132.
2. H. Sun, Z.-H. Wang, Y. He, Direct Observation of Spatiotemporal Heterogeneous Gelation by Rotational Tracking of a Single Anisotropic Nanoprobe, ACS Nano. 2019, 13 (10), 11334-11342.
3. Q. Pan, H.-S. Zhao, X.-J. Lin, Y. He, Spatiotemporal Heterogeneity of Reactions in Solution Observed with High-Speed Single-Nanorod Rotational Sensing, Angew. Chem. Int. Ed. 2019, 58 (25), 8389-8393.
4. X.-J. Lin, Q. Pan, Y. He, In situ detection of protein corona on single particle by rotational diffusivity, Nanoscale. 2019, 11 (39), 18367-18374.
5. J.-J. Feng, X. Cao, Q. Pan, Y. He, Direct observation of single plasmonic metal nanoparticle reaction in microcolumn with chromatic-aberration-free LASER light-sheet scattering imaging, Electrophoresis. 2019, 40 (16-17), 2227-2234.
6. F. Ge, J.-F. Xue, Z.-H. Wang, B. Xiong, Y. He, Real-time observation of dynamic heterogeneity of gold nanorods on plasma membrane with darkfield microscopy, Sci. China Chem. 2019, 62 (8), 1072-1081.
7. X. Cao, G. Lei, J.-J. Feng, Q. Pan, X.-D. Wen, Y. He, A Novel Color Modulation Analysis Strategy through Tunable Multiband Laser for Nanoparticle Identification and Evaluation, Anal. Chem. 2018, 90 (4), 2501-2507.
8. B. Xiong, Z.-R. Huang, H.-Y. Zou, C.-Y. Qiao, Y. He, E. S. Yeung, Single Plasmonic Nanosprings for Visualizing Reactive-Oxygen-Species-Activated Localized Mechanical Force Transduction in Live Cells, ACS Nano. 2017, 11 (1), 541-548.
9. C.-Y. Qiao, J. Wu, Z.-R. Huang, X. Cao, J.-Y. Liu, B. Xiong, Y. He, E. S. Yeung, Sequence-Modulated Interactions between Single Multivalent DNA-Conjugated Gold Nanoparticles, Anal. Chem. 2017, 89 (10), 5592-5597.
10. Q. Pan, Y. He, Recent advances in self-propelled particles, Sci. China Chem. 2017, 60 (10), 1293-1304.
11. J.-J. Feng, Y. He, Collective motion of bacteria and their dynamic assembly behavior, Sci. China Mater. 2017, 60 (11), 1079-1092.
12. X.-D. Cheng, X. Cao, B. Xiong, Y. He, E. S. Yeung, Background-free three-dimensional selective imaging of anisotropic plasmonic nanoparticles, Nano Research. 2017, 10 (4), 1423-1433.
13. X. Cao, J.-J. Feng, Q. Pan, B. Xiong, Y. He, E. S. Yeung, Direct Imaging of Single Plasmonic Metal Nanoparticles in Capillary with Laser Light-Sheet Scattering Imaging, Anal. Chem. 2017, 89 (5), 2692-2697.
14. H. Li, H. Luo, Z. Zhang, Y.-J. Li, B. Xiong, C.-Y. Qiao, X. Cao, T. Wang, Y. He, G.-Y. Jing, Direct observation of nanoparticle multiple-ring pattern formation during droplet evaporation with dark-field microscopy, Phys. Chem. Chem. Phys. 2016, 18 (18), 13018-13025.
15. L. Peng, X. Cao, B. Xiong, Y. He, E. S. Yeung, A novel scattering switch-on detection technique for target-induced plasmon-coupling based sensing by single-particle optical anisotropy imaging, Chem. Commun. (Camb). 2016, 52 (48), 7616-9.
16. Y.-H. Peng, B. Xiong, L. Peng, H. Li, Y. He, E. S. Yeung, Recent advances in optical imaging with anisotropic plasmonic nanoparticles, Anal. Chem. 2015, 87 (1), 200-15.
17. D. Xu, Y. He, E. S. Yeung, Direct Observation of the Orientation Dynamics of Single Protein-Coated Nanoparticles at Liquid/Solid Interfaces. Angew. Chem. Int. Ed. 2014, 53 (27), 6951-6955.
18. D. Xu, Y. He, E. S. Yeung, Direct Imaging of Transmembrane Dynamics of Single Nanoparticles with Darkfield Microscopy: Improved Orientation Tracking at Cell Sidewall. Anal. Chem. 2014, 86 (7), 3397-3404.
19. J. Hao; B. Xiong, X. Cheng, Y. He, E. S. Yeung, High-Throughput Sulfide Sensing with Colorimetric Analysis of Single Au–Ag Core–Shell Nanoparticles. Anal. Chem. 2014, 86 (10), 4663-4667.
20. X. Cheng, D. Dai, L. Peng, Y. He, E. S. Yeung. Color Difference Amplification between Gold Nanoparticles in Colorimetric Analysis with Actively Controlled Multiband Illumination. Anal. chem. 2014, 86(15), 7584-7592.
21. X. Cheng, D. Dai, D. Xu, Y. He, E. S. Yeung, Subdiffraction-Limited Plasmonic Imaging with Anisotropic Metal Nanoparticles. Anal. Chem. 2014, 86 (5), 2303-2307
22. H. Shen, B. Xiong, R. Xu, X. Cheng, Y. He, E. S. Yeung. 3D darkfield imaging and single particle tracking of peptide-coated nanocargoes in live cell. Anal. Meth. 2014, 6(23):9202-9205.
23. D. Dai, D. Xu, X. Cheng,Y. He. Direct imaging of single gold nanoparticle etching: Sensitive detection of lead ions. Anal. Meth. 2014, 6(13):4507-4511.
24. B. Xiong, R. Zhou, J. Hao, Y. Jia, Y. He, E. S. Yeung, Highly sensitive sulphide mapping in live cells by kinetic spectral analysis of single Au-Ag core-shell nanoparticles. Nat. Commun. 2013, 4:1708.
25. R. Zhou, H. Zhou, B. Xiong, Y. He, E. S. Yeung, Pericellular Matrix Enhances Retention and Cellular Uptake of Nanoparticles. J. Am. Chem. Soc. 2012, 134 (32), 13404-13409.
26. L. Xiao, Y. Qiao, Y. He, Yeung, E. S. Yeung, Imaging Translational and Rotational Diffusion of Single Anisotropic Nanoparticles with Planar Illumination Microscopy. J Am. Chem Soc. 2011, 133 (27), 10638-10645.
27. L. Xiao, L. Wei, X. Cheng, Y. He, E. S. Yeung, Noise-Free Dual-Wavelength Difference Imaging of Plasmonic Resonant Nanoparticles in Living Cells. Anal. Chem. 2011, 83 (19), 7340-7347.
28. J. Cheng, Y. Liu, X. Cheng, Y. He, E. S. Yeung, Real Time Observation of Chemical Reactions of Individual Metal Nanoparticles with High-Throughput Single Molecule Spectral Microscopy. Anal. Chem. 2010, 82 (20), 8744-8749.
29. L. Xiao, L. Wei, Y. He, E. S. Yeung. Single Molecule Biosensing Using Color Coded Plasmon Resonant Metal Nanoparticles. Anal. chem. 2010, 82(14), 6308-6314.
30. L. Xiao, Y. Qiao, Y. He, E. S. Yeung. Three Dimensional Orientational Imaging of Nanoparticles with Darkfield Microscopy. Anal. chem. 2010, 82(12), 5268-5274.
1 Protocol published
Long-distance Transport in Bacterial Swarms Revealed by Single Nanoparticle Tracking
Authors:  Jingjing Feng and Yan He, date: 11/05/2020, view: 314, Q&A: 0

During swarming, high density flagella-driven bacteria migrate collectively in a swirling pattern on wet agar surfaces, immersed in a thin viscous fluid layer called “swarm fluid”. Though the fluid environment has essential role in the

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