Denis Chrétien
  • Research scientist, IGDR
Research focus
  • Molecular biology
  • Microtubules, cryo-electron microscopy
  • 2 Author merit

Lab information

Denis Chrétien Lab
https://igdr.univ-rennes1.fr/

2 Protocols published
使用TubuleJ从冷冻电子显微镜图像确定微管晶格参数
Authors:  Siou Ku, Cédric Messaoudi, Charlotte Guyomar, Charles Kervrann and Denis Chrétien, date: 11/05/2020, view: 1489, Q&A: 0

The α-β tubulin heterodimer undergoes subtle conformational changes during microtubule assembly. These can be modulated by external factors, whose effects on microtubule structure can be characterized on 2D views obtained by cryo-electron

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存在不良成核核苷酸类似物的微管种晶组装
Authors:  Siou Ku, Claire Heichette, Laurence Duchesne and Denis Chrétien, date: 08/20/2020, view: 1621, Q&A: 0
Microtubule dynamic instability is driven by the hydrolysis of the GTP bound to the β-subunit of the α-β tubulin heterodimer. Nucleotide analogues are commonly used to mimic the different steps of the tubulin GTPase cycle, but most of them are poor ...
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