Shen Dong
  • Research scientist, UCSF
Research focus
  • Immunology
  • Immunology, T cell biology, T cell receptor, Type 1 diabetes


Ph.D., Institut Pasteur, 2009

Lab information

Jeffrey Bluestone laboratory


2018 - Sibener LV, Fernandes RA, Kolawole EM, Carbone CB, Liu F, McAffee D, Birnbaum ME, Yang X, Su LF, Yu W, Dong S, Gee MH, Jude KM, Mark M. Davis MM, Groves JT, Goddard WA III, Heath JR, Evavold BD, Vale RD, Garcia KC. Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding. Cell, 2018 Jul 26;174(3):672-687.e27.

2018 - Spence A, Purtha W, Tam J, Dong S, Kim Y, Ju CH, Sterling T, Nakayama M, Robinson WH, Bluestone JA, Anderson MS, Tang Q. Revealing the specificity of regulatory T cells in murine autoimmune diabetes. PNAS, 2018 May 15;115(20):5265-5270.

2015 - Spangler JB, Tomala J, Luca VC, Dong S, Ring AM, Votavova P, Pepper M, Kovar M, Garcia KC.
Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms. Immunity, 2015 May 19;42(5):815-25

2014 - Birnbaum ME, Mendoza JL, Sethi DK, Dong S, Glanville J, Dobbins J, Ozkan E, Davis MM, Wucherpfennig KW, Garcia KC.Deconstructing the peptide-MHC specificity of T cell recognition. Cell, 2014 May 22;157(5):1073-87.

2013 - Dong S, Maiella S, Xhaard A, Pang Y, Wenandy L, Larghero J, Becavin C, Benecke A, Bianchi E, Socié G and Rogge L. Multi-parameter single-cell profiling of human CD4+FOXP3+ regulatory T cell populations in homeostatic conditions and during graft-versus-host disease. Blood, 2013 Sep 5;122(10):1802-12.

2012 - Birnbaum ME, Dong S, Garcia KC. Diversity-oriented approaches for interrogating T-cell receptor repertoire, ligand recognition, and function. Immunological Reviews, 2012 Nov;250 (1):82-101.

2010 - Dong S, Corre B, Nika K, Pellegrini S, and Michel F. TCR signal initiation induced by low-grade stimulation requires the cooperation of LAT in human T cells. PLoS One, 2010 Nov 30;5(11):e15114.

2006 - Dong S, Corre B, Foulon E, Dufour E, Veillette A, Acuto O, Michel F. TCR induces linker for activation of T cell-dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2. J Exp Med, 2006 Oct 30;203(11):2509-18.
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