Kossay Zaoui Université de Montréal Hospital Centre Research Centre (CRCHUM)
1 protocol

Stephanie Duhamel
  • Research associate, Goodman Cancer Research Center, McGill University, 2018-
Research focus
  • -
  • 1 Author merit

Education

PhD, Université de Montréal, Canada, 2011

Publications

• Zaoui, K., Rajadurai, C. V., Duhamel, S. and Park, M. (2019). Arf6 regulates RhoB subcellular localization to control cancer cell invasion. J Cell Biol 218(11): 3812-3826.
• Zaoui, K., Duhamel, S., Parachoniak, C. A. and Park, M. (2019). CLIP-170 spatially modulates receptor tyrosine kinase recycling to coordinate cell migration. Traffic 20(3): 187-201.
• Goyette, M. A., Duhamel, S., Aubert, L., Pelletier, A., Savage, P., Thibault, M. P., Johnson, R. M., Carmeliet, P., Basik, M., Gaboury, L., Muller, W. J., Park, M., Roux, P. P., Gratton, J. P. and Cote, J. F. (2018). The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression. Cell Rep 23(5): 1476-1490.
• Duhamel, S., Goyette, M. A., Thibault, M. P., Filion, D., Gaboury, L. and Cote, J. F. (2018). The E3 Ubiquitin Ligase HectD1 Suppresses EMT and Metastasis by Targeting the +TIP ACF7 for Degradation. Cell Rep 22(4): 1016-1030.
• Duhamel, S., Girondel, C., Dorn, J. F., Tanguay, P. L., Voisin, L., Smits, R., Maddox, P. S. and Meloche, S. (2016). Deregulated ERK1/2 MAP kinase signaling promotes aneuploidy by a Fbxw7beta-Aurora A pathway. Cell Cycle 15(12): 1631-1642.
• Grote, D., Moison, C., Duhamel, S., Chagraoui, J., Girard, S., Yang, J., Mayotte, N., Coulombe, Y., Masson, J. Y., Brown, G. W., Meloche, S. and Sauvageau, G. (2015). E4F1 is a master regulator of CHK1-mediated functions. Cell Rep 11(2): 210-219.
• Duhamel, S., Hebert, J., Gaboury, L., Bouchard, A., Simon, R., Sauter, G., Basik, M. and Meloche, S. (2012). Sef downregulation by Ras causes MEK1/2 to become aberrantly nuclear localized leading to polyploidy and neoplastic transformation. Cancer Res 72(3): 626-635.
• Voisin, L., Julien, C., Duhamel, S., Gopalbhai, K., Claveau, I., Saba-El-Leil, M. K., Rodrigue-Gervais, I. G., Gaboury, L., Lamarre, D., Basik, M. and Meloche, S. (2008). Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors. BMC Cancer 8: 337.
• Meriane, M., Duhamel, S., Lejeune, L., Galipeau, J. and Annabi, B. (2006). Cooperation of matrix metalloproteinases with the RhoA/Rho kinase and mitogen-activated protein kinase kinase-1/extracellular signal-regulated kinase signaling pathways is required for the sphingosine-1-phosphate-induced mobilization of marrow-derived stromal cells. Stem Cells 24(11): 2557-2565.
1 Protocol published
Colorimetric RhoB GTPase Activity Assay
Authors:  Kossay Zaoui and Stephanie Duhamel, date: 05/05/2020, view: 1490, Q&A: 0
The Ras homologous protein (Rho) GTPase subfamily, including RhoA, RhoB, and RhoC are small molecules (~21 kDa) that act as molecular switches in a wide range of signaling pathways to orchestrate biological processes associated with both ...
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