Jaira Ferreira de Vasconcellos Uniformed Services University of the Health Sciences & Henry Jackson Foundation for the Advancement of Military Medicine
2 protocols

Pilar Villacampa Institut d'Investigacio Biomedica de Bellvitge (IDIBELL)
6 protocols

Ran Chen Zhejiang JFK Biological Technology Co. Ltd.
3 protocols

Vasudevan Achuthan Dana Farber Cancer Institute
7 protocols

Chhuttan L Meena
  • Post-Doc, National Chemical laboratory NCL Pune
Research focus
  • Biochemistry
  • Self-assembly, Peptide, medicinal chemistry

Lab information

G.J. Sanjayan


1. Meena C.L.; Teixido, M.; Giralt. E.; Sanjayan, G.J.; Design and Synthesis of Sila-DKP- BBB-shuttle: that’s enhance blood–brain barrier transport of temozolamide (Under preparation)
2. Meena C.L.; Shaliwal, R.P.; Kumar, V.; Deep. R.; Mahajan, D.; Identification and development of thiophene based small molecules as potent inhibitors of Mycobacterium Tuberculosis (MTB), Bioorg. Med. Chem. Lett. (Under preparation)
3. Meena C.L.; Singh. D.; Weinmüller, M.; Florian, R.; Zahler, H.; Sanjayan, G.J.; Synthesis of New Cyclic peptides as Integrins Inhibitors That Exhibit Selectivity to αVβ3 proteins ACS Med. Chem. Lett. (Communicated)
4. Meena, C.L. Ingole, S. Thakur, A; Rajpoot, S. Nandekar P.; Sangamwar, A.T; Sharma. ;Sharma S. S.; Jain, R; Discovery of low affinity Thyrotropin-releasing hormone (TRH)-like peptide that exhibit potent inhibition of scopolamine-induced memory impairment in mice, RSC Adv., 2015, 5, 56872, DOI: 10.1039/c5ra06935a
5. Meena, C.L. Ingole, S. Thakur, A; Rajpoot, S. Nandekar P.; Sangamwar, A.T; Sharma, S.S.; Kumar N.; Jain, R; Synthesis of CNS active Thyrotropin-releasing Hormone (TRH)-like peptides: Biological evaluation and effect on cognitive impairment induced by cerebral ischemia in mice, Bioorg. Med. Chem. 2015, 23 5641–5653, . DOI: 10.1016/j.bmc.2015.07.022.
6. Meena, C.L. Thakur, A; Rajpoot, S. Nandekar P.; Sangamwar, A.T; Sharma, S.S.; Kumar; Jain, R; Synthesis and biology of ring-modified L-Histidine containing Thyrotropin-releasing hormone (TRH) analogues. Eur. J. Med. Chem 2016, 111, 72-83, DOI.org/10.1016/j.ejmech.2016.01.038
7. Monga, V.; Meena, C. L.; Rajput, S.; Pawar, C.; Sharma, S. S.; Lu, X.; Gershengorn, M. C.; Jain, R. Synthesis, receptor binding and CNS pharmacological studies of new Thyrotropin-releasing Hormone (TRH) analogues. ChemMedChem.2011, 6, 531-543, DOI.org/10.1002/cmdc.201000481
8. Monga, V., Meena, C.L., Kaur, N., Kumar, S., Pawar, C., Sharma, S.S. and Jain R., Facile Synthesis of N-α-Boc-1,2-Dialkyl- L–His Utility in the Synthesis of Thyrotropin-Releasing Hormone (TRH) Analogs and Evaluation of the CNS Activity, J. Heterocyclic Chem., 2008, 45, 1603-1610, DOI.org/10.1002/jhet.5570450608
9. Monga V.; Meena, C. L.; Kaur, N.; Jain, R.; Chemistry and biology of Thyrotropin-releasing hormone (TRH) and its analogs. Curr. Med. Chem. 2008, 15, 2718-2733. DOI: 10.2174/092986708786242912, Impact factor 4.07
10. Kumar, L., Meena, C.L.; Pawar, Y.B.; Wahlang, B.; Tikoo, K.; Jain, R.; Bansal A.K.; Effect of Counterions on Physicochemical Properties of Prazosin Salts. AAPS PharmSciTech. 2013, 14, 141-150, DOI.org/10.1208/s12249-012-9889-x
11. Rajput, S.K., Singh, J.,N.; Ingole, S.; Jain, R.; Kaur, N.; Monga, V.; Meena, C.L.; Jain, R.; Sharma.S.S., Neuropharmacological profile of L-pGlu-(1-benzyl)- L -His- L -ProNH2, a newer Thyrotropin-releasing hormone analog: Effects on seizure models, sodium current, cerebral blood flow and behavioral parameters,. Epilepsy Research, 2009, 87, 223-233, DOI:10.1016/j.eplepsyres. 2009.09.007
12. Rajpoot, S. K.; Siddiqui, M. A.; Kumar, V.; Meena, C. L.; Pant, A. B.; Jain, R.; Sharma, S. S. Protective effects of L-pGlu- (2-propyl)- L -His-L-ProNH2 a newer thyrotropin releasing hormone analog in in vitro and in vivo models of cerebral ischemia. Peptides 2011, 32, 1225-1231.
13. Rajput, S.K.; Krishnamurthy, S.; Pawar, C.; Kaur, N.; Monga, V.; Meena, C.L.; Jain, R.; Sharma, S.S.; Antiepileptic potential and behavioral profile of L -pGlu-(2-propyl)– L-His– L -ProNH2, a newer Thyrotropin-releasing hormone analogue, Epilepsy & Behaviour 14, 2009, 48-53 impact factor 2.335, DOI:10.1016/j.yebeh.2008.10.006
14. Khomane, K.; Kumar, L.; Meena, C.L.; Jain, R.; Bansal, A.; NP-647, a novel TRH analogue: Investigating physicochemical parameters critical for its oral and parenteral delivery. Int. J. Pharma. 2011, 406, 1–2, 15, 21-30, DOI: 10.1016/j.ijpharm.2010.12.025.
15. Kailas S. Khomane, K. Nandekar, P.; Wahlang, B.; Sheikh, N.; Pawar, Y.B.; Meena, C.L.; Sangamwar, T.; Jain, R.; K. Tikoo and Bansal. A.K., Mechanistic Insights into PEPT1-Mediated Transport of a Novel-Antiepileptic, NP-647. Mol. Pharmaceutics. 2012, 9, 2458-2468. DOI: 10.1021/mp200672d
16. Khomane K. S.; Meena, C. L.; Jain, R.; Bansal, A. K. Novel thyrotropin-releasing hormone analogs: a patent review. Expert Opin. Ther. Pat. 2011, 21, 1673-1691, DOI: 10.1517/13543776.2011.623127
17. Rajput, S.K.; Jitendra Singh, J.; Meena, C.L.; Jain, R.; Adity Pant, A.; and Sharma, S.S.; L-pGlu-(1-Benzyl)-L-His-L-Pro-NH2 a Newer Thyrotropin Releasing Hormone (TRH) Analogues with anti-convulsive and neuroprotective properties FASEB.J. 24. 2017, 2, Supliment 762.9,
18. Kumar V. ; Rana, A. ; Meena, C.; Sharma, N. ; Kumara, Y.; Mahajan, D. ; Electrophilic activation of carboxylic anhydrides for nucleophilic acylation reactions, Synthesis, 2018, 15, (19), 3902-3910, DOI: 10.1055/s-0037-1609564
19. Kumar V. ; Rana, A. ; Meena, C.; Sharma, N. ; Kumara, Y.; Mahajan, D. Triflic anhydride promoted synthesis of primary amides and their conversion to nitriles Syn,Open, 2018, 2, 180-191, DOI: 10.1055/s-0037-1610154
20. Kidwai, S.; Bouzeyen, R.; Chakraborti, S.;Khare,N.; Sumana Das,S.; Gosain, T.P.; Behura, A.; Meena, C.L.; Dhiman, R.; Essafi,, M.; Bajaj,A.; Saini, D.K.; Srinivasan, N.; Mahajan, D.; Singh R.; NU-6027 inhibits growth of Mycobacterium tuberculosis by targeting Protein Kinase D and Protein Kinase G, Antimicrobial Agents and Chemotherapy 2019, AAC.00996-19; DOI: 10.1128/AAC.00996-19
❖ Kumar L., Alam, M.S., Meena, C.L., Jain, R. Bansal, A.K. Fexofenadine hydrochloride, Profiles of Drug Substances, Excipients and Related Methodology, 153-192, 34, 2009. DOI.org/10.1016/S1871-5125(09)34004-2
❖ Sonje, V.M., Kumar, L. Meena, C.L., Kohli, G. Puri, V., Jain, R., Bansal A.K.; Atorvastatin calcium, Profiles of Drug Substances, Excipients and Related Methodology, 35, 1-70, 2010. doi.org/10.1016/S1871-5125(10)35001-1
2 Protocols reviewed
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The CRISPR/Cas9 system is a powerful tool for genome editing, wherein the RNA-guided nuclease Cas9 can be directed to introduce double-stranded breaks (DSBs) at a targeted locus. In mammalian cells, these DSBs are typically repaired through ...
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