Patrik Medstrand Department of Translational Medicine, Clinical Virology, Lund University, Malmö
1 protocol

Sara Karlson Dept Translational Medicin, Lund University, 2015-0
1 protocol

Zsófia Szojka Department of Biochemistry and Molecular Biology, University of Debrecen, 2015-2019
1 protocol

Marianne Jansson
  • Associate professor, Senior Lecturer, Laboratory Medicine, Lund University
Research focus
  • -
  • 1 Author merit

Education

Ph.D., Karolinska Institutet, Sweden

Publications

Since 2014
• Karlsson I, Tingstedt J, Özkaya Şahin G, Hansen M, Szojka Z, Buggert M, Biague A, da Silva Z, Månsson F, Esbjörnsson J, Norrgren H, Medstrand P, Sweden-Guinea-Bissau Cohort Research Group, Fomsgaard A* and Jansson M*. Cross-reactive antibodies with the capacity to mediate HIV-1 Env-targeted ADCC identified in HIV-2-infected individuals. *Equal contributions. J Infect Dis. 219(11):1749-1754, 2019
• Esbjörnsson J, Jansson M, Jespersen S, Månsson F, Hønge BL, Lindman J, Medina C, da Silva ZJ, Norrgren H, Medstrand P, Rowland-Jones SL, Wejse C. AIDS Res Ther. Review. 16:24, 2019
• Esbjörnsson J, Månsson F, Lindman J, Rowland-Jones SL, Jansson M, Medstrand P, Norrgren H; SWEGUB CORE GROUP. New insights are game-changers in HIV-2 disease management - Authors' reply. Lancet HIV. 6(4): e214-e215. 2019
• Elvstam O, Medstrand P, Jansson M, Isberg PE, Gisslén M, Björkman P. Is low-level HIV-1 viraemia associated with elevated levels of markers of immune activation, coagulation and cardiovascular disease? HIV Med. doi: 10.1111/hiv.12756, 2019
• Olsson O, Björkman P, Jansson M, Tolera Balcha T, Mulleta D, Yeba H, Valfridsson C, Carlsson F and Skogmar S. Plasma profiles of inflammatory markers associated with active tuberculosis in antiretroviral therapy naïve HIV-positive adults in Ethiopia. OFID, 6(2): ofz015, 2019
• Palm A, Lemey P, Jansson M, Månsson F, Biague A, da Silva ZJ, Norrgren H, Esbjörnsson J*, and Medstrand P*. High HIV-2 evolutionary rate is associated with faster disease progression. MBio, 10(1). pii: e01245-18, 2019 *Equal contributions.
• Esbjörnsson J*, Månsson F*, Kvist A, da Silva ZJ, Andersson S, Fenyö EM, Isberg PE, Lindman J, Palm A, Jansson M, Medstrand P and Norrgren H. Long follow-up reveals high proportions of HIV-2 related AIDS and mortality. Lancet HIV, pii: S2352-3018(18)30254-6, 2018 *Equal contributions.
• Wilhelmson S, Månsson F, Lopatko Lindman J, Biai A, Esbjörnsson J, Norrgren H, Jansson M, Medstrand P, SWEGUB CORE group. Prevalence of HIV-1 pretreatment drug resistance among treatment naïve pregnant women in Bissau, Guinea-Bissau. PLoS One 13(10): e0206406, 2018
• Buggert M, Nguyen S, McLane LM, Steblyanko M, Anikeeva N, Paquin-Proulx D, Del Rio Estrada PM, Ablanedo-Terrazas Y, Noyan K, Reuter MA, Demers K, Sandberg JK, Eller MA, Streeck H, Jansson M, Nowak P, Sönnerborg A, Canaday DH, Naji A, Wherry EJ, Robb ML, Deeks SG, Reyes-Teran G, Sykulev Y, Karlsson AC and Betts MR. Limited immune surveillance in lymphoid tissue by cytolytic CD4+ T cells during health and HIV disease. PLoS Pathog. 14(4): e1006973, 2018
• König Walles J, Tesfaye F, Jansson M, Tolera Balcha T, Winqvist N, Kefeni M, Garoma Abeya S, Belachew F, Sturegård E and Björkman P. Performance of QuantiFERON-TB Gold Plus for detection of latent tuberculosis infection in pregnant women living in a tuberculosis- and HIV-endemic setting. PLoS One. 2018 13(4):e0193589, 2018
• Nasi A, Amu S, Göthlin M, Jansson M, Nagy N, Chiodi F and Réthi B. Dendritic Cell Response to HIV-1 Is Controlled by Differentiation Programs in the Cells and Strain-Specific Properties of the Virus. Front Immunol. 13;8:244, 2017
• Buggert M, Frederiksen J, Lund O, Biague A, Nielsen M, Tauriainen J, Norrgren H, Medstrand P, the SWEGUB CORE group, Karlsson A, and Jansson M. CD4+ T type 1 cells with an activated and exhausted phenotype distinguish progressive disease during aviremic HIV-2 infection. AIDS 30:2415-2426, 2016
• Lund JM, Broliden K, Pyra MN, Thomas KK, Donnell D, Irungu E, Muwonge TR, Mugo N, Jansson M, Mackelprang R, Baeten JM, and Lingappa JR for the Partners PrEP Study. HIV-1-neutralizing IgA is detected in genital secretions of highly HIV-1 exposed seronegative women on oral pre-exposure prophylaxis. J Virol. pii: JVI.01482-16. 2016
• Bächle SM, Malone DFG, Buggert M, Karlsson A, Isberg PE, Biague A, Norrgren H, Medstrand P, the SWEGUB CORE group, Moll M, Sandberg JK and Jansson M. Elevated level of iNKT and NK cell activation correlates with disease progression in HIV-1 and HIV-2 infections. AIDS 30(11):1713-22. 2016.
• Karlsson U, Repits J, ¬¬¬Antonsson L, Ahlm Cederfjäll C, Ljungberg B, Ålenius M, Gisslén M, Svennerholm B, Esbjörnsson J, and Jansson M. Late stage R5 HIV-1 isolates display reduced baseline sensitivity to in vitro inhibition by Maraviroc– correlation with an altered mode of CCR5 use. J Acquir Immune Defic Syndr, 71(3): e79-82. 2016.
• Skogmar S, Schön T, Balcha TT, Jemal ZH, Sturegård E, Jansson M and Björkman P. Plasma levels of neopterin and C-reactive protein (CRP) in tuberculosis (TB) with and without HIV coinfection in relation to CD4 cell count. Plos One, 10(12): e0144292. doi: 10.1371/journal.pone.0144292. 2015.
• Palm A, Esbjörnsson J, Mansson F, Biague AJ, da Silva ZJ, Norrgren H, Jansson M, and Medstrand P, SWEGUB CORE Group. Co-circulation of several similar but unique HIV-1 recombinant forms in Guinea-Bissau revealed by near full-length genomic sequencing. AIDS Res Hum Retroviruses. 31:938-45, doi: 10.1089/AID.2015.0073, 2015.
• Nowroozalizadeh S, and Jansson M. HIV-2 infection: the role of immune activation in pathogenesis. AIDS Encyclopedia (Springer). 2015.
• Månsson F, Medstrand P, Jansson M, Fenyo EM, and Esbjörnsson J. Transmission HIV-2. AIDS Encyclopedia (Springer). 2015.
• Borggren M and Jansson M. The evolution of HIV interactions with co-receptors and mannose C-type lectin receptors. Molecular Basis of Viral infections. Prog Mol Biol Transl Sci, 129:109-40. 2015.
• Sheik-Khalil E, Bray M, Özkaya Şahin G, Scarlatti G, Jansson M, Carpenter A, and Fenyö EM. Automated image-based assay for evaluation of HIV neutralization and cell-to-cell fusion inhibition. BMC Infectious Diseases, 14:472. doi: 10.1186/1471-2334-14-472, 2014.
• Buggert M, Tauriainen T, Yamamoto T, Frederiksen J, Ivarsson MA, Jakob Michaëlsson J, Lund O, Hejdeman B, Jansson M, Sönnerborg S, Koup RA, Betts MR, and Karlsson AC. T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infection. PLOS Pathogens, 10(7): e1004251. doi: 10.1371/journal.ppat.1004251, 2014.
• Uchtenhagen H, Schiffner T, Bowles E, Heyndrickx L, LaBranche C, Applequist SE, Jansson M, De Silva T, Willem Back J, Achour A, Scarlatti G, Fomsgaard A, Montefiori D, Stewart-Jones G, and Spetz A-L. Boosting of HIV-1 Neutralizing Antibody Responses by a Distally Related Retroviral Envelope Protein. J Immunol pii: 1301898. 2014.
• Esbjörnsson J, Månsson F, Kvist A, Isberg PE, Biague AJ, da Silva ZJ, Jansson M, Fenyö EM, Norrgren H and Medstrand P. Increased survival among HIV-1 and HIV-2 dual-infected individuals compared to HIV-1 single-infected individuals. AIDS, 949-957, DOI: 10.1097/QAD.0000000000000101, 2014.
• Kiene M, Rethi B, Jansson M, Dillon S, Lee E, Wilson C, Pöhlmann S, and Chiodi F. Toll-like receptor 3 signalling up-regulates expression of the HIV co-receptor GPR15 on human CD4+ T cells. PloS ONE, 9(2): e88195. 2014.
• Palm AA, Esbjörnsson J, Månsson F, Kvist A, Isberg PE, Biague A, Da Silva Z, Jansson M, Norrgren H, and Medstrand P. Faster disease progression rate among seroincident individuals infected with recombinant HIV-1 CRF02_AG or A3/CRF02_AG compared to those with non-recombinant HIV-1 sub subtype A3. 2 J Infect Dis, 209(5):721-8, 2014.
• Esbjörnsson J, Månsson F, Kvist A, Isberg PE, Nowroozalizadeh S, Biague AJ, da Silva ZJ, Jansson M, Fenyö EM, Norrgren H and Medstrand P. Effect of HIV-2 infection on HIV-1 disease progression and mortality. AIDS, 28:614-615, 2014
1 Protocol published
Quantification of HIV-2 DNA in Whole Blood
Authors:  Zsófia Szojka, Sara Karlson, Marianne Jansson and Patrik Medstrand, date: 10/20/2019, view: 258, Q&A: 0
Time to AIDS infection is longer with HIV-2, compared to HIV-1, but without antiretroviral therapy both infections will cause AIDS-related mortality. In HIV-2 infection, monitoring of antiretroviral treatment (ART) efficacy is challenging since a ...
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