Shriya Saha Neurobiology, NCBS, TIFR, 2020-
1 protocol

Moumita Basu Biochemistry, University of Calcutta, West Bengal, 2014-2020
1 protocol

Anindita Ukil
  • Assistant Professor, Department of Biochemistry, University of Calcutta, Kolkata
Research focus
  • Microbiology
  • 1 Author merit


PhD, University of Calcutta, India, 2005


• Saha S, Dutta A, Jana K and Ukil A. (2020). Leishmania donovani targets host transcription factor NRF2 to activate anti-oxidant enzyme HO-1 and transcriptional repressor ATF3 for establishing infection. Communicated…….
• Basu M, Saha S and Ukil A (2020). Spectrophotometric Assessment of Heme Oxygenase-1 Activity in Leishmania-infected 1 Macrophages. Bioprotocol (in press)
• Basu M, Gupta P, Dutta A, JanaK and Ukil A. (2020) Increased host ATP efflux and its conversionto extracellular adenosine is crucial for establishing Leishmania infection. J Cell Sci. [in press].
• ChatterjeeT, Pattanayak R, Ukil A, Chowdhury S and Bhattacharyya M (2019). Autophagy protects peripheral blood mononuclear cells against inflammation, oxidative and nitrosative stress in diabetic dyslipidemia.Free Radical Biol. Med. 143:309-323.
• Roy S, SahaS, Gupta P, Ukil A and Das PK. (2019) Crosstalk of PD-1 signaling with SIRT1/FOXO-1 axis in progression of visceral leishmaniasis. J Cell Sci. 132 [E-pub ahead of print].
• Saha S, Basu B, Guin S, Roy A, Gupta P, Mitterstiller AM, Weiss G. Jana K and Ukil A. (2019).Leishmania donovani exploits macrophage heme oxygenase-1 to neutralize oxidative burst and TLR signalling dependent host defense. J Immunol 202:827-840.
• DowariP, Saha S, Pramanik B, Ahmed S, Singha N, Ukil A and Das D. (2018). Multiple cross-linking strategy to form size tuneable bio-polymer with efficient cell adhesion and proliferation property. Biomacromolecules.19:3994-4002.
• Saha A, Basu M and Ukil A.(2018). Recent advances in understanding Leishmaniadonovani infection: the importance of diverse host regulatory pathways. IUBMB Life. 70:93–601.
• Singha N, Gupta P, Pramanik B, Ahmed S, Dasgupta A, Ukil A and Das D. (2017) Hydrogelation of a naphthalene diimideappended peptide amphiphile and its application in cell-imaging and intracellular pH sensing. Biomacromolecules.18:3630-3641.
• Gupta, AK, Ghosh, K, Palit S, Barua J, Das PK and Ukil A. (2017) Leishmaniadonovani inhibits inflammasome-dependent macrophage activation by exploiting the negative regulatory proteins A20 and UCP2. FASEB J.31: 5087-5101.
• RoyS, Gupta P, PalitS, BasuM, UkilA and Das PK. (2017) The role of PD1 in regulation of macrophage apoptosis and its subversion byLeishmaniadonovani. Clin. Translational Immunol.6: e137.
• Gupta P, Srivastav S, Saha S, Das PK and Ukil A. (2016) Leishmaniadonovaniinhibits macrophage apoptosis and pro-inflammatory response through AKT-mediated regulation of β-catenin and FOXO-1. Cell Death Differ.23: 1815-1826.
• Giri J, Srivastav S, Basu M, Palit S, Gupta P andUkil A. (2016) Leishmaniadonovaniexploits myeloid cell leukemia 1 (MCL-1) protein to prevent mitochondria dependent host cell apoptosis J. Biol. Chem.291: 3496-3507.
• Srivastav S, Saha A, Barua J, Ukil A and Das PK. (2015) IRAK-M regulates the inhibition of TLR-mediated macrophage immune response late during in vitro Leishmaniadonovaniinfection. Eur. J. Immunol.45: 2787-2797.
• Gupta P, Das PK and Ukil A. (2015) Antileishmanial effect of 18β-glycyrrhetinic acid is mediated by TLR dependent canonical and noncanonical p38 activation. Antimicrob. Agents Chemother.59: 2531-2539.
• Saha A, Biswas A, Srivastav S, Mukherjee M, Das PK and Ukil A. (2014) Prostaglandin E2 negatively regulates the production of Th1/Th17 cytokines and proinflammatory chemokines in visceral leishmaniasis. J. Immunol.193: 2330-2339.
• Gupta P, Giri J, Srivastav S, Chande AG, Mukhopadhyaya R, Das PKandUkil A. (2014) Leishmaniadonovani negatively regulates TLR4 mediated host response by preventing ubiquitination dependent degradation of TRAF3. FASEB J. 28: 1756-1768.
• Srivastav S, Basu Ball W, Gupta P, Giri J,UkilA and Das PK.(2014) Leishmaniadonovaniprevents oxidative burst mediated apoptosis of host macrophages through selective induction of suppressors of cytokine signalling (SOCS) proteins. J. Biol. Chem.289: 1092-1105.
• Ghosh K, Sharma G, Saha A, Kar S, Das PK and Ukil A. (2013) Successful therapy of visceral leishmaniasis with curdlan involves T-helper 17 Cytokines J. Infec. Dis.207: 1016–1025.
• Ukil A, Kar S, Srivastav S, Ghosh K and Das PK. (2011) Curative effect of 18-glycyrrhetinic acid in experimental visceral leishmaniasis depends on phosphatase-dependent modulation of cellular MAP kinases. PLoS ONE, e29062.
• Kar S, Ukil A and Das PK. (2011) Cystatin cures visceral leishmaniasis by NF-kB mediated proinflammatory response through co-ordination of TLR/MyD88 signaling with p105-Tpl2-ERK pathway. Eur J Immunol 41: 116-127.
• Kar S, Ukil A, Sharma G and Das PK. (2010) MAPK directed phosphatases preferentially regulate pro- and anti-inflammatory cytokines in experimental visceral leishmaniasis: involvement of distinct protein kinase C isoforms. J Leukocyte Biol 88: 9-20.
• Kar S, Ukil A and Das PK. (2009) Signaling events leading to the curative effect of cystatin on experimental visceral leishmaniasis: involvement of ERK1/2, NF-?B and JAK/STAT pathways. Eur J Immunol 39:741-751.
• Mukherjee S, Ukil A and Das PK. (2007) Immunomodulatory peptide from cystatin, a natural cysteine protease inhibitor, using leishmaniasis as model macrophage disease. Antimicrob Agents Chemother 51: 1700-1707.
• Ukil A, Maity S and Das PK. (2006) Protection from experimental colitis by theaflavin-3,3'-digallate correlates with inhibition of IKK and NF-kappaB activation. Br. J. Pharmacol.149:121-131.
• Ukil A, Maity S and Das P. K. (2006) Biodistribution and pharmacokinetics of theaflavin-3,3`-digallate, the major antioxidant of black tea, in mice. Int J Pharmacol 2: 240-246.
• Karmakar S, Ukil A, Mukherjee S and Das PK. (2006) Regulation of guanylyl cyclase by intracellular Ca2+ in relation to the infectivity of the protozoan parasite Leishmaniadonovani. Int. J. Biochem. Cell Biol.38: 1277-1289.(Impact factor 3.91)
• Ukil A, Biswas A, Das T and Das PK. (2005) 18 Beta-glycyrrhetinic acid triggers curative Th1 response and nitric oxide up-regulation in experimental visceral leishmaniasis associated with the activation of NF-kappaB. J. Immunol 175: 1161-1169.
• Maity S, Ukil A, Karmakar S, Datta N, Chaudhuri T, Vedasiromoni JR, Ganguly DK and Das PK. (2003) Thearubigin, the major polyphenol of black tea, ameliorates mucosal injury in trinitrobenzene sulfonic acid-induced colitis. Eur J Pharmacol 470: 103-112.
• Ukil A, Maity S, Karmakar S, Datta N, Vedasiromoni JR and Das PK. (2003) Curcumin, the major component of food flavour turmeric, reduces mucosal injury in trinitrobenzenesulphonic acid-induced colitis. Br J Pharmacol 139: 209-218.
1 Protocol published
Spectrophotometric Assessment of Heme Oxygenase-1 Activity in Leishmania-infected Macrophages
Authors:  Moumita Basu, Shriya Saha and Anindita Ukil, date: 04/05/2020, view: 2116, Q&A: 0
Heme oxygenase-1 (HO-1) is a stress responsive enzyme that metabolizes heme and releases free iron, carbon monoxide (CO), and biliverdin (BV), which rapidly undergoes conversion to bilirubin (BL). Estimation of bilirubin is the basis of HO-1 assay. ...
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