Patricia Ward Department of Cell Biology, Emory University School of Medicine, Atlanta, GA
1 protocol

Arthur W. English
  • Professor, Department of Cell Biology, Emory University School of Medicine
Research focus
  • -
  • 1 Author merit


PhD, University of Illinjois, USA, 1974


· McGregor CE, Irwin AM, English AW. The Val66Met BDNF Polymorphism and Peripheral Nerve Injury: Enhanced Regeneration in Mouse Met-Carriers Is Not Further Improved With Activity-Dependent Treatment. Neurorehabil Neural Repair. 2019 May 8;:1545968319846131. doi: 10.1177/1545968319846131. [Epub ahead of print] PubMed PMID: 31068076; NIHMSID:NIHMS1526478.
· McGregor CE, English AW. The Role of BDNF in Peripheral Nerve Regeneration: Activity-Dependent Treatments and Val66Met. Front Cell Neurosci. 2018;12:522. doi: 10.3389/fncel.2018.00522. eCollection 2018. Review. PubMed PMID: 30687012; PubMed Central PMCID: PMC6336700.
· Sahoo PK, Lee SJ, Jaiswal PB, Alber S, Kar AN, Miller-Randolph S, Taylor EE, Smith T, Singh B, Ho TS, Urisman A, Chand S, Pena EA, Burlingame AL, Woolf CJ, Fainzilber M, English AW, Twiss JL. Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration. Nat Commun. 2018 Aug 22;9(1):3358. doi: 10.1038/s41467-018-05647-x. PubMed PMID: 30135423; PubMed Central PMCID: PMC6105716.
· Jaiswal PB, Mistretta OC, Ward PJ, English AW. Chemogenetic Enhancement of Axon Regeneration Following Peripheral Nerve Injury in the SLICK-A Mouse. Brain Sci. 2018 May 22;8(5). doi: 10.3390/brainsci8050093. PubMed PMID: 29786639; PubMed Central PMCID: PMC5977084.
· Gregor RJ, Maas H, Bulgakova MA, Oliver A, English AW, Prilutsky BI. Time course of functional recovery during the first 3 mo after surgical transection and repair of nerves to the feline soleus and lateral gastrocnemius muscles. J Neurophysiol. 2018 Mar 1;119(3):1166-1185. doi: 10.1152/jn.00661.2017. Epub 2017 Nov 29. PubMed PMID: 29187556; PubMed Central PMCID: PMC5899315.
· Ward PJ, Clanton SL 2nd, English AW. Optogenetically enhanced axon regeneration: motor versus sensory neuron-specific stimulation. Eur J Neurosci. 2018 Feb;47(4):294-304. doi: 10.1111/ejn.13836. Epub 2018 Feb 10. PubMed PMID: 29363200.
· Struebing FL, Wang J, Li Y, King R, Mistretta OC, English AW, Geisert EE. Differential Expression of Sox11 and Bdnf mRNA Isoforms in the Injured and Regenerating Nervous Systems. Front Mol Neurosci. 2017;10:354. doi: 10.3389/fnmol.2017.00354. eCollection 2017. PubMed PMID: 29209164; PubMed Central PMCID: PMC5701613.
· Jaiswal PB, Tung JK, Gross RE, English AW. Motoneuron activity is required for enhancements in functional recovery after peripheral nerve injury in exercised female mice. J Neurosci Res. 2017 Aug 3;. doi: 10.1002/jnr.24109. [Epub ahead of print] PubMed PMID: 28771790; PubMed Central PMCID: PMC5797526.
· Mokarram N, Dymanus K, Srinivasan A, Lyon JG, Tipton J, Chu J, English AW, Bellamkonda RV. Immunoengineering nerve repair. Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5077-E5084. doi: 10.1073/pnas.1705757114. Epub 2017 Jun 13. PubMed PMID: 28611218; PubMed Central PMCID: PMC5495274.
· Jaiswal PB, English AW. Chemogenetic enhancement of functional recovery after a sciatic nerve injury. Eur J Neurosci.2017 May;45(10):1252-1257. doi: 10.1111/ejn.13550. Epub 2017 Mar 28. PubMed PMID: 28244163; PubMed Central PMCID: PMC5438293.
· Gordon T, English AW. Strategies to promote peripheral nerve regeneration: electrical stimulation and/or exercise. Eur J Neurosci. 2016 Feb;43(3):336-50. doi: 10.1111/ejn.13005. Epub 2015 Aug 14. Review. PubMed PMID: 26121368; PubMed Central PMCID: PMC4695319.
· Sabatier MJ, English AW. Pathways Mediating Activity-Induced Enhancement of Recovery From Peripheral Nerve Injury.Exerc Sport Sci Rev. 2015 Jul;43(3):163-71. doi: 10.1249/JES.0000000000000047. Review. PubMed PMID: 25906422; PubMed Central PMCID: PMC4470799.
· Brandt J, Evans JT, Mildenhall T, Mulligan A, Konieczny A, Rose SJ, English AW. Delaying the onset of treadmill exercise following peripheral nerve injury has different effects on axon regeneration and motoneuron synaptic plasticity. J Neurophysiol. 2015 Apr 1;113(7):2390-9. doi: 10.1152/jn.00892.2014. Epub 2015 Jan 28. PubMed PMID: 25632080; PubMed Central PMCID: PMC4416629.
· Krakowiak J, Liu C, Papudesu C, Ward PJ, Wilhelm JC, English AW. Neuronal BDNF signaling is necessary for the effects of treadmill exercise on synaptic stripping of axotomized motoneurons. Neural Plast. 2015;2015:392591. doi: 10.1155/2015/392591. Epub 2015 Mar 31. PubMed PMID: 25918648; PubMed Central PMCID: PMC4397030.
· Srinivasan A, Tahilramani M, Bentley JT, Gore RK, Millard DC, Mukhatyar VJ, Joseph A, Haque AS, Stanley GB, English AW, Bellamkonda RV. Microchannel-based regenerative scaffold for chronic peripheral nerve interfacing in amputees.Biomaterials. 2015 Feb;41:151-65. doi: 10.1016/j.biomaterials.2014.11.035. Epub 2014 Dec 9. PubMed PMID: 25522974; PubMed Central PMCID: PMC4324612.
· Gore RK, Choi Y, Bellamkonda R, English A. Functional recordings from awake, behaving rodents through a microchannel based regenerative neural interface. J Neural Eng. 2015 Feb;12(1):016017. doi: 10.1088/1741-2560/12/1/016017. Epub 2015 Jan 21. PubMed PMID: 25605627; PubMed Central PMCID: PMC4324563.
· English AW, Wilhelm JC, Ward PJ. Exercise, neurotrophins, and axon regeneration in the PNS. Physiology (Bethesda).2014 Nov;29(6):437-45. doi: 10.1152/physiol.00028.2014. Review. PubMed PMID: 25362637; PubMed Central PMCID: PMC4280152.
· Liu C, Ward PJ, English AW. The effects of exercise on synaptic stripping require androgen receptor signaling. PLoS One.2014;9(6):e98633. doi: 10.1371/journal.pone.0098633. eCollection 2014. PubMed PMID: 24887087; PubMed Central PMCID: PMC4041790.
· Thompson NJ, Sengelaub DR, English AW. Enhancement of peripheral nerve regeneration due to treadmill training and electrical stimulation is dependent on androgen receptor signaling. Dev Neurobiol. 2014 May;74(5):531-40. doi: 10.1002/dneu.22147. Epub 2013 Nov 29. PubMed PMID: 24293191; PubMed Central PMCID: PMC4730387.
· English AW, Liu K, Nicolini JM, Mulligan AM, Ye K. Small-molecule trkB agonists promote axon regeneration in cut peripheral nerves. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16217-22. doi: 10.1073/pnas.1303646110. Epub 2013 Sep 16. PubMed PMID: 24043773; PubMed Central PMCID: PMC3791704.
· Boeltz T, Ireland M, Mathis K, Nicolini J, Poplavski K, Rose SJ, Wilson E, English AW. Effects of treadmill training on functional recovery following peripheral nerve injury in rats. J Neurophysiol. 2013 Jun;109(11):2645-57. doi: 10.1152/jn.00946.2012. Epub 2013 Mar 6. PubMed PMID: 23468390; PubMed Central PMCID: PMC3680800.
· Wood K, Wilhelm JC, Sabatier MJ, Liu K, Gu J, English AW. Sex differences in the effectiveness of treadmill training in enhancing axon regeneration in injured peripheral nerves. Dev Neurobiol. 2012 May;72(5):688-98. doi: 10.1002/dneu.20960. PubMed PMID: 21805686; PubMed Central PMCID: PMC3676277.
· Gutekunst CA, Stewart EN, Franz CK, English AW, Gross RE. PlexinA4 distribution in the adult rat spinal cord and dorsal root ganglia. J Chem Neuroanat. 2012 May;44(1):1-13. doi: 10.1016/j.jchemneu.2012.03.002. Epub 2012 Mar 23. PubMed PMID: 22465808; PubMed Central PMCID: PMC3367504.
· Wilhelm JC, Xu M, Cucoranu D, Chmielewski S, Holmes T, Lau KS, Bassell GJ, English AW. Cooperative roles of BDNF expression in neurons and Schwann cells are modulated by exercise to facilitate nerve regeneration. J Neurosci. 2012 Apr 4;32(14):5002-9. doi: 10.1523/JNEUROSCI.1411-11.2012. PubMed PMID: 22492055; PubMed Central PMCID: PMC3382119.
· Sabatier MJ, To BN, Rose S, Nicolini J, English AW. Chondroitinase ABC reduces time to muscle reinnervation and improves functional recovery after sciatic nerve transection in rats. J Neurophysiol. 2012 Feb;107(3):747-57. doi: 10.1152/jn.00887.2011. Epub 2011 Nov 2. PubMed PMID: 22049333; PubMed Central PMCID: PMC3774643.
· Willis DE, Xu M, Donnelly CJ, Tep C, Kendall M, Erenstheyn M, English AW, Schanen NC, Kirn-Safran CB, Yoon SO, Bassell GJ, Twiss JL. Axonal Localization of transgene mRNA in mature PNS and CNS neurons. J Neurosci. 2011 Oct 12;31(41):14481-7. doi: 10.1523/JNEUROSCI.2950-11.2011. PubMed PMID: 21994364; PubMed Central PMCID: PMC3205917.
· English AW, Wilhelm JC, Sabatier MJ. Enhancing recovery from peripheral nerve injury using treadmill training. Ann Anat. 2011 Jul;193(4):354-61. doi: 10.1016/j.aanat.2011.02.013. Epub 2011 Mar 12. Review. PubMed PMID: 21498059; PubMed Central PMCID: PMC3137663.
· English AW, Cucoranu D, Mulligan A, Rodriguez JA, Sabatier MJ. Neurotrophin-4/5 is implicated in the enhancement of axon regeneration produced by treadmill training following peripheral nerve injury. Eur J Neurosci. 2011 Jun;33(12):2265-71. doi: 10.1111/j.1460-9568.2011.07724.x. Epub 2011 May 30. PubMed PMID: 21623957; PubMed Central PMCID: PMC3118869.
· Sabatier MJ, To BN, Nicolini J, English AW. Effect of axon misdirection on recovery of electromyographic activity and kinematics after peripheral nerve injury. Cells Tissues Organs. 2011;193(5):298-309. doi: 10.1159/000323677. Epub 2011 Mar 17. PubMed PMID: 21411964; PubMed Central PMCID: PMC3128140.
· Sabatier MJ, To BN, Nicolini J, English AW. Effect of slope and sciatic nerve injury on ankle muscle recruitment and hindlimb kinematics during walking in the rat. J Exp Biol. 2011 Mar 15;214(Pt 6):1007-16. doi: 10.1242/jeb.051508. PubMed PMID: 21346129; PubMed Central PMCID: PMC3044077.
· Hamilton SK, Hinkle ML, Nicolini J, Rambo LN, Rexwinkle AM, Rose SJ, Sabatier MJ, Backus D, English AW. Misdirection of regenerating axons and functional recovery following sciatic nerve injury in rats. J Comp Neurol. 2011 Jan 1;519(1):21-33. doi: 10.1002/cne.22446. PubMed PMID: 21120925; PubMed Central PMCID: PMC3703664.
· Chen Y, Wang Y, Chen L, Sun C, English AW, Wolpaw JR, Chen XY. H-reflex up-conditioning encourages recovery of EMG activity and H-reflexes after sciatic nerve transection and repair in rats. J Neurosci. 2010 Dec 1;30(48):16128-36. doi: 10.1523/JNEUROSCI.4578-10.2010. PubMed PMID: 21123559; PubMed Central PMCID: PMC3005210.
· English AW, Cucoranu D, Mulligan A, Sabatier M. Treadmill training enhances axon regeneration in injured mouse peripheral nerves without increased loss of topographic specificity. J Comp Neurol. 2009 Nov 10;517(2):245-55. doi: 10.1002/cne.22149. PubMed PMID: 19731339; PubMed Central PMCID: PMC2804895.
· Clements IP, Kim YT, English AW, Lu X, Chung A, Bellamkonda RV. Thin-film enhanced nerve guidance channels for peripheral nerve repair. Biomaterials. 2009 Aug;30(23-24):3834-46. doi: 10.1016/j.biomaterials.2009.04.022. Epub 2009 May 15. PubMed PMID: 19446873; PubMed Central PMCID: PMC2753861.
1 Protocol published
Optical Stimulation and Electrophysiological Analysis of Regenerating Peripheral Axons
Authors:  Patricia J. Ward and Arthur W. English, date: 06/20/2019, view: 2480, Q&A: 0
Although axons in the peripheral nervous system can regenerate, functional recovery after nerve injuries is poor. Activity-based therapies, such as exercise and electrical stimulation, enhance the regeneration of cut peripheral axons. Despite their ...
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