Ya-Wen Liu
  • Assistant Professor, Institute of Molecular Medicine, National Taiwan University, 2014-
Research focus
  • Cell biology
  • 1 Author merit

Education

PhD, National Taiwan University, Taiwan (Republic of China), 2006

Publications

• Julie, L.#, Chuang, M.C.#, Lin, S.S.#, Joseph, J., Su, Y.A., Hsieh, T.L. Chang, Y.C., Liu, A.P. and Liu, Y.W.* (2019). An Acute Decrease in Plasma Membrane Tension Induces Macropinocytosis via PLD2 Activation. Journal of Cell Science, 132 (17). doi: 10.1242/jcs.232579. (selected as Research Highlight)
• Chuang, M.C., Lin, S.S., Ohniwa, R.L., Lee, G.H., Su, Y.A., Chang, Y.C., Tang, M.J. and Liu, Y.W. * (2019). Tks5 and Dynamin-2 enhance actin bundle rigidity in invadosomes to promote myoblast fusion. Journal of Cell Biology. 218(5), 1670-85.
• Lin, S.S. and Liu, Y.W. * (2019). Mechanical stretch induces mTOR recruitment and activation at the phosphatidic acid-enriched macropinosome in muscle cell. Front Cell Dev Biol. doi: 10.3389/fcell.2019.00078.
• Cheng, A.M.S., Yin, H.Y., Chen A., Liu, Y.W., Chuang, M.C., He, H., Tighe, S., Sheha,. H., Liao, S.L. * (2016). Celecoxib and pioglitazone as potential therapeutics for regulating TGF-β-induced hyaluronan in dysthyroid myopathy. Investigative Opthalmology & Visial Science, 57(4),1951-1959.
• Chin, Y.H.*, Lee, A.*, Kan, H.W., Laiman J., Chuang, M.C., Hsieh, S.T. and Liu, Y.W. * (2015), Dynamin-2 mutations associated with centronuclear myopathy are hypermorphic and lead to T-tubule fragmentation. Hum Mol Genet 24, 5542-54 (* equal contribution).
• Chen, C.H., Lee, A., Liao, C.P., Liu, Y.W., and Pan, C.L. * (2014). RHGF-1/PDZ-RhoGEF and retrograde DLK-1 signaling drive neuronal remodeling on microtubule disassembly. Proc Natl Acad Sci USA, 111(46):16568-73.
• Hsu, J.W., Chen, Z.J., Liu, Y.W. and Lee, F.J. * (2014). Mechanism of action of the flippase Drs2p in modulating GTP hydrolysis of Arl1p. Journal of Cell Science, 127(Pt 12):2615-20.
• Liu, Y.W., Mattila, J.P. and Schmid, S.L. (2013), Dynamin-catalyzed membrane fission requires coordinated GTP hydrolysis. PLOS ONE 8, e55691.
• Tsai, P.C., Hsu, J.W., Liu, Y.W., Chen, K.Y. and Lee, F.J. * (2013), Arl1p regulates spatial membrane organization at the trans-Golgi network through interaction with Arf-GEF Gea2p and flippase Drs2p. Proc Natl Acad Sci USA 110, E668-77 
• Chen, K.Y., Tsai, P.C., Liu, Y.W. and Lee, F.J. * (2012), Competition between the golgin Imh1p and the Gcs1p GAP stabilizes activated Arl1p at the late-Golgi. J. Cell Sci. 125, 4586-96.
• Liu, Y.W., Su, A.I. and Schmid, S.L* (2012), The evolution of dynamin to regulate clathrin-mediated endocytosis. BioEssays 34, 643-7.
• Liu, Y.W., Lukiyanchuk, V., and Schmid, S.L. * (2011), Common membrane trafficking defects of disease-associated dynamin 2 mutations. Traffic 12, 1620-33.
• Liu, Y.W.*, Neumann, N.*, Ramachandran, R., Ferguson, S.M., Pucadyil, T.J., and Schmid, S.L. (2011), Differential curvature sensing and generating activities of dynamin isoforms provide opportunities for tissue-specific regulation. Proc Natl Acad Sci USA 108, 234-42. (* equal contribution; selected and evaluated at “Faculty of 1000”.)
• Ramachandran, R., Pucadyil, T.J., Liu, Y.W., Acharya, S., Leonard, M., Lukiyanchuk, V., and Schmid, S.L. * (2009), Membrane insertion of the pleckstrin homology domain variable loop 1 is critical for dynamin-catalyzed vesicle scission. Mol. Biol. Cell. 20:4630-9.
• Chappie, J.S., Acharya, S., Liu, Y.W., Leonard, M., Pucadyil, T.J., and Schmid, S.L. * (2009), An intramolecular signaling element that modulates dynamin function in vitro and in vivo. Mol. Biol. Cell. 20: 3561-71.
• Liu, Y.W., Surka, M.C., Schroeter, T., Lukiyanchuk, V., and Schmid, S.L. * (2008), Isoform and splice-variant specific functions of dynamin-2 revealed by analysis of conditional knock-out cells. Mol. Biol. Cell. 19: 5347-59. (selected for “InCytes of MBC”)
• Tsai, P.C. *, Lee, S.W. *, Liu, Y.W.*, Chu, C.W., Chen, K.Y., Ho, J.C., and Lee, F.J. * (2008), Afi1p functions as an Arf3p polarization-specific docking factor for development of polarity. J Biol Chem. 283: 16915-27. (* equal contribution.)
• Liu, Y.W., Lee, S. W., and Lee, F.J. * (2006), Arl1p is involved in transport of the GPI-anchored protein Gas1p from the late Golgi to the plasma membrane. J. Cell Sci. 119: 3845-55. (highlighted in the “IN this Issue”)
• Liu, Y.W., Huang, C.F., Huang, K.B., and Lee, F.J. * (2005), Role for Gcs1p in regulation of Arl1p at trans-Golgi compartments. Mol. Biol. Cell. 16: 4024-33. (selected in the “Faculty of 1000”)
• Huang, C. F. *, Liu, Y.W. *, Tung, L., Lin, C.H., and Lee, F.J. * (2003), Role for Arf3p in development of polarity, but not endocytosis, in Saccharomyces cerevisiae. Mol. Biol. Cell. 14: 3834-47. (* equal contribution.)
1 Protocol published
F-actin Bundle Sedimentation Assay
Authors:  Shan-Shan Lin, Mei-Chun Chuang and Ya-Wen Liu, date: 11/05/2019, view: 119, Q&A: 0
Understanding the molecular mechanism governing the higher-order regulation of actin dynamics requires chemically-defined and quantitative assays. Recently, the membrane remodeling large GTPase, dynamin, has been identified as a new actin ...
We use cookies on this site to enhance your user experience. By using our website, you are agreeing to allow the storage of cookies on your computer.