Neil J. Ingham
  • Senior Staff Scientist, Wolfson CARD, King's College London, UK, 2012-0; Genetics of Deafness, Wellcome Sanger Institute, UK, 2007-2012
Research focus
  • -
  • 1 Author merit

Education

PhD, University of Leeds, UK, 1996

Publications

• Ingham, N. J., Pearson, S. A., Vancollie, V. E., Rook, V., Lewis, M. A., Chen, J., Buniello, A., Martelletti, E., Preite, L., Lam, C. C., Weiss, F. D., Powis, Z., Suwannarat, P., Lelliott, C. J., Dawson, S. J., White, J. K. and Steel, K. P. (2019). Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS Biol 17(4): e3000194.
• Bowl, M. R., Simon, M. M., Ingham, N. J., Greenaway, S., Santos, L., Cater, H., Taylor, S., Mason, J., Kurbatova, N., Pearson, S., Bower, L. R., Clary, D. A., Meziane, H., Reilly, P., Minowa, O., Kelsey, L., International Mouse Phenotyping, C., Tocchini-Valentini, G. P., Gao, X., Bradley, A., Skarnes, W. C., Moore, M., Beaudet, A. L., Justice, M. J., Seavitt, J., Dickinson, M. E., Wurst, W., de Angelis, M. H., Herault, Y., Wakana, S., Nutter, L. M. J., Flenniken, A. M., McKerlie, C., Murray, S. A., Svenson, K. L., Braun, R. E., West, D. B., Lloyd, K. C. K., Adams, D. J., White, J., Karp, N., Flicek, P., Smedley, D., Meehan, T. F., Parkinson, H. E., Teboul, L. M., Wells, S., Steel, K. P., Mallon, A. M. and Brown, S. D. M. (2017). A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction. Nat Commun 8(1): 886.
• Ingham, N. J., Steel, K. P. and Drescher, U. (2017). On the role of ephrinA2 in auditory function. Hear Res 350: 11-16.
• Buniello, A., Ingham, N. J., Lewis, M. A., Huma, A. C., Martinez-Vega, R., Varela-Nieto, I., Vizcay-Barrena, G., Fleck, R. A., Houston, O., Bardhan, T., Johnson, S. L., White, J. K., Yuan, H., Marcotti, W. and Steel, K. P. (2016). Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing. EMBO Mol Med 8(3): 191-207.
• Ebrahim, S., Ingham, N. J., Lewis, M. A., Rogers, M. J. C., Cui, R., Kachar, B., Pass, J. C. and Steel, K. P. (2016). Alternative Splice Forms Influence Functions of Whirlin in Mechanosensory Hair Cell Stereocilia. Cell Rep 15(5): 935-943.
• Ingham, N. J., Carlisle, F., Pearson, S., Lewis, M. A., Buniello, A., Chen, J., Isaacson, R. L., Pass, J., White, J. K., Dawson, S. J. and Steel, K. P. (2016). S1PR2 variants associated with auditory function in humans and endocochlear potential decline in mouse. Sci Rep 6: 28964.
• Ingham, N. J., Itatani, N., Bleeck, S. and Winter, I. M. (2016). Enhancement of forward suppression begins in the ventral cochlear nucleus. Brain Res 1639: 13-27.
• Morozko, E. L., Nishio, A., Ingham, N. J., Chandra, R., Fitzgerald, T., Martelletti, E., Borck, G., Wilson, E., Riordan, G. P., Wangemann, P., Forge, A., Steel, K. P., Liddle, R. A., Friedman, T. B. and Belyantseva, I. A. (2015). ILDR1 null mice, a model of human deafness DFNB42, show structural aberrations of tricellular tight junctions and degeneration of auditory hair cells. Hum Mol Genet 24(3): 609-624.
• Chen, J., Ingham, N., Kelly, J., Jadeja, S., Goulding, D., Pass, J., Mahajan, V. B., Tsang, S. H., Nijnik, A., Jackson, I. J., White, J. K., Forge, A., Jagger, D. and Steel, K. P. (2014). Spinster homolog 2 (spns2) deficiency causes early onset progressive hearing loss. PLoS Genet 10(10): e1004688.
• Maguire, S., Estabel, J., Ingham, N., Pearson, S., Ryder, E., Carragher, D. M., Walker, N., Sanger, M. G. P. S. a. P. T., Bussell, J., Chan, W. I., Keane, T. M., Adams, D. J., Scudamore, C. L., Lelliott, C. J., Ramirez-Solis, R., Karp, N. A., Steel, K. P., White, J. K. and Gerdin, A. K. (2014). Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene. PLoS One 9(3): e91807.
• Chen, J., Ingham, N., Clare, S., Raisen, C., Vancollie, V. E., Ismail, O., McIntyre, R. E., Tsang, S. H., Mahajan, V. B., Dougan, G., Adams, D. J., White, J. K. and Steel, K. P. (2013). Mcph1-deficient mice reveal a role for MCPH1 in otitis media. PLoS One 8(3): e58156.
• Johnson, S. L., Kuhn, S., Franz, C., Ingham, N., Furness, D. N., Knipper, M., Steel, K. P., Adelman, J. P., Holley, M. C. and Marcotti, W. (2013). Presynaptic maturation in auditory hair cells requires a critical period of sensory-independent spiking activity. Proc Natl Acad Sci U S A 110(21): 8720-8725.
• Lorente-Canovas, B., Ingham, N., Norgett, E. E., Golder, Z. J., Karet Frankl, F. E. and Steel, K. P. (2013). Mice deficient in H+-ATPase a4 subunit have severe hearing impairment associated with enlarged endolymphatic compartments within the inner ear. Dis Model Mech 6(2): 434-442.
• Simon, M. M., Greenaway, S., White, J. K., Fuchs, H., Gailus-Durner, V., Wells, S., Sorg, T., Wong, K., Bedu, E., Cartwright, E. J., Dacquin, R., Djebali, S., Estabel, J., Graw, J., Ingham, N. J., Jackson, I. J., Lengeling, A., Mandillo, S., Marvel, J., Meziane, H., Preitner, F., Puk, O., Roux, M., Adams, D. J., Atkins, S., Ayadi, A., Becker, L., Blake, A., Brooker, D., Cater, H., Champy, M. F., Combe, R., Danecek, P., di Fenza, A., Gates, H., Gerdin, A. K., Golini, E., Hancock, J. M., Hans, W., Holter, S. M., Hough, T., Jurdic, P., Keane, T. M., Morgan, H., Muller, W., Neff, F., Nicholson, G., Pasche, B., Roberson, L. A., Rozman, J., Sanderson, M., Santos, L., Selloum, M., Shannon, C., Southwell, A., Tocchini-Valentini, G. P., Vancollie, V. E., Westerberg, H., Wurst, W., Zi, M., Yalcin, B., Ramirez-Solis, R., Steel, K. P., Mallon, A. M., de Angelis, M. H., Herault, Y. and Brown, S. D. (2013). A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains. Genome Biol 14(7): R82.
• Kuhn, S., Ingham, N., Pearson, S., Gribble, S. M., Clayton, S., Steel, K. P. and Marcotti, W. (2012). Auditory function in the Tc1 mouse model of down syndrome suggests a limited region of human chromosome 21 involved in otitis media. PLoS One 7(2): e31433.
• Basel-Vanagaite, L., Dallapiccola, B., Ramirez-Solis, R., Segref, A., Thiele, H., Edwards, A., Arends, M. J., Miro, X., White, J. K., Desir, J., Abramowicz, M., Dentici, M. L., Lepri, F., Hofmann, K., Har-Zahav, A., Ryder, E., Karp, N. A., Estabel, J., Gerdin, A. K., Podrini, C., Ingham, N. J., Altmuller, J., Nurnberg, G., Frommolt, P., Abdelhak, S., Pasmanik-Chor, M., Konen, O., Kelley, R. I., Shohat, M., Nurnberg, P., Flint, J., Steel, K. P., Hoppe, T., Kubisch, C., Adams, D. J. and Borck, G. (2012). Deficiency for the ubiquitin ligase UBE3B in a blepharophimosis-ptosis-intellectual-disability syndrome. Am J Hum Genet 91(6): 998-1010.
• Norgett, E. E., Golder, Z. J., Lorente-Canovas, B., Ingham, N., Steel, K. P. and Karet Frankl, F. E. (2012). Atp6v0a4 knockout mouse is a model of distal renal tubular acidosis with hearing loss, with additional extrarenal phenotype. Proc Natl Acad Sci U S A 109(34): 13775-13780.
• Kuhn, S., Johnson, S. L., Furness, D. N., Chen, J., Ingham, N., Hilton, J. M., Steffes, G., Lewis, M. A., Zampini, V., Hackney, C. M., Masetto, S., Holley, M. C., Steel, K. P. and Marcotti, W. (2011). miR-96 regulates the progression of differentiation in mammalian cochlear inner and outer hair cells. Proc Natl Acad Sci U S A 108(6): 2355-2360.
• Hilton, J. M., Lewis, M. A., Grati, M., Ingham, N., Pearson, S., Laskowski, R. A., Adams, D. J. and Steel, K. P. (2011). Exome sequencing identifies a missense mutation in Isl1 associated with low penetrance otitis media in dearisch mice. Genome Biol 12(9): R90.
• Ingham, N. J., Pearson, S. and Steel, K. P. (2011). Using the Auditory Brainstem Response (ABR) to Determine Sensitivity of Hearing in Mutant Mice. Curr Protoc Mouse Biol 1(2): 279-287.
• Schutz, M., Scimemi, P., Majumder, P., De Siati, R. D., Crispino, G., Rodriguez, L., Bortolozzi, M., Santarelli, R., Seydel, A., Sonntag, S., Ingham, N., Steel, K. P., Willecke, K. and Mammano, F. (2010). The human deafness-associated connexin 30 T5M mutation causes mild hearing loss and reduces biochemical coupling among cochlear non-sensory cells in knock-in mice. Hum Mol Genet 19(24): 4759-4773.
1 Protocol published
Evoked Potential Recordings of Auditory Brainstem Activity in the Mouse: An Optimized Method for the Assessment of Hearing Function of Mice
Author:  Neil J. Ingham, date: 12/05/2019, view: 377, Q&A: 0
Hearing loss is a common sensory deficiency suffered by millions worldwide. It is a heterogeneous condition and genetics plays a critical role in its etiology. Gene variants can fundamentally alter hearing function, or predispose the auditory system ...
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