Stefano Cagnin
  • Faculty, University of Padova
Research focus
  • Systems biology
  • In my lab research is based on genomic and transcriptomic approaches to identify non-coding RNAs involved in skeletal muscle and heart pathologies.
  • 1 Author merit


PhD, University of Padova, 2007

Lab information

Stefano Cagnin Lab


• Alessio E, Buson L, Chemello F, Peggion C, Grespi F, Martini P, Massimino ML, Pacchioni B, Millino C, Romualdi C, Bertoli A, Scorrano L, Lanfranchi G, Cagnin S* (2019) Single cell analysis reveals the involvement of the long non-coding RNA Pvt1 in the modulation of muscle atrophy and mitochondrial network Nucleic Acids Research doi:10.1093/nar/gkz007. [ISSN: 0305-1048 – I.F. 11.56]. * corresponding author.
• Chemello F, Grespi F, Zulian A, Cancellara P, Herbert-Chatelan E, Martini P, Bean C, Alessio E, Ferrazza R, Laveder P, Guella G, Reggiani C, Romualdi C, Bernardi P, Scorrano L, Cagnin S*, Lanfranchi G* (2018) Lipid Utilization in Skeletal Muscle Cells is Modulated in vitro by Specific miRNAs BioRxiv doi: *co-corresponding author
• Peggion C, Stella R, Chemello F, Massimino M L, Arrigoni G, Cagnin S, Biancotto G, Franchin C, Sorgato M C, Bertoli A. (2018) The Prion Protein Regulates Synaptic Transmission by Controlling the Expression of Proteins Key to Synaptic Vesicle Recycling and Exocytosis. Mol. Neurobiol.; doi: 10.1007/s12035-018-1293-4. [ISSN: 0893-7648 – I.F. 5.076]
• Pagliari M, Munari F, Toffoletto M, Lonardi S, Chemello F, Codolo G, Millino C, Della Bella C, Pacchioni B, Vermi W, Fassan M, de Bernard M*, Cagnin S.* (2017) Helicobacter pylori Affects the Antigen Presentation Activity of Macrophages Modulating the Expression of the Immune Receptor CD300E through miR-4270. Front Immunol.; 8:1288. [ISSN: 1664-3224 - I.F. 6.429] * co-corresponding author
• Martini P, Paracchini L, Caratti G, Mello-Grand M, Fruscio R, Beltrame L, Calura E, Sales G, Ravaggi A, Bignotti E, Odicino FE, Sartori E, Perego P, Katsaros D, Craparotta I, Chiorino G, Cagnin S, Mannarino L, Ceppi L, Mangioni C, Ghimenti C, D'Incalci M, Marchini S, Romualdi C. (2016) lncRNAs as Novel Indicators of Patients' Prognosis in Stage I Epithelial Ovarian Cancer: A Retrospective and Multicentric Study. Clin Cancer Res.; 23(9):2356-2366. [ISSN: 1078-0432 – I.F. 9.619].
• Mammucari C, Gherardi G, Zamparo I, Raffaello A, Boncompagni S, Chemello F, Cagnin S, Braga A, Zanin S, Pallafacchina G, Zentilin L, Sandri M, De Stefani D, Protasi F, Lanfranchi G, Rizzuto R. (2015) The mitochondrial calcium uniporter controls skeletal muscle trophism in vivo. Cell Rep.;10(8):1269-79. [ISSN: 2211-1247 – I.F.: 8.358].
• Chemello F, Mammucari C, Gherardi G, Rizzuto R, Lanfranchi G, Cagnin S.* (2015) Gene expression changes of single skeletal muscle fibers in response to modulation of the mitochondrial calcium uniporter (MCU) Genomics Data; 5:64-67. [ISSN: 2213-5960]. * corresponding author.
• Soares RJ, Cagnin S, Chemello F, Silvestrin M, Musaro A, De Pitta C, Lanfranchi G, Sandri M. (2014) Involvement of microRNAs in the regulation of muscle wasting during catabolic conditions. J Biol Chem. 8;289(32):21909-25. [ISSN 0021-9258 – I.F.: 4.6].
• Iop L, Bonetti A, Naso F, Rizzo S, Cagnin S, Bianco R, Dal Lin C, Martini P, Poser H, Franci P, Lanfranchi G, Busetto R, Spina M, Basso C, Marchini M, Gandaglia A, Ortolani F, Gerosa G. (2014) Decellularized allogeneic heart valves demonstrate self-regeneration potential after a long-term preclinical evaluation. PLoS One. 18;9(6):e99593. [ISSN 1932-6203 – I.F.: 3.534].
• Martini P, Sales G, Calura E, Cagnin S, Chiogna M, Romualdi C. (2014) timeClip: pathway analysis for time course data without replicates. BMC Bioinformatics.15 Suppl 5:S3. [ISSN 1460-2059 - I.F.: 4.621].
• Fede C, Millino C, Pacchioni B, Celegato B, Compagnin C, Martini P, Selvestrel F, Mancin F, Celotti L, Lanfranchi G, Mognato M, Cagnin S*. (2014) Altered gene transcription in human cells treated with Ludox® silica nanoparticles. Int J Environ Res Public Health. 28;11(9):8867-90. [ISSN 1660- 4601 – I.F.: 1.993]. * corresponding author.
• Martini P, Sales G, Brugiolo M, Gandaglia A, Naso F, De Pittà C, Spina M, Gerosa G, Chemello F, Romualdi C, Cagnin S*, Lanfranchi G. (2014) Tissue-specific expression and regulatory networks of pig microRNAome. PLoS One. 3;9(4):e89755. [ISSN 1932-6203 – I.F.: 3.534]. * corresponding author.
• Martini P, Sales G, Calura E, Brugiolo M, Lanfranchi G, Romualdi C, Cagnin S*. (2013) Systems biology approach to the dissection of the complexity of regulatory networks in the S. scrofa cardiocirculatory system. Int J Mol Sci. 14(11):23160-87. [ISSN 1422-0067 - I.F.: 2.339]. * corresponding author.
• Kyriakides T., Pegoraro E., Hoffman EP., Piva L., Cagnin S. S., Lanfranchi G., Griggs RC., Nelson SF. (2011) SPP1 genotype is a determinant of disease severity in Duchenne muscular dystrophy: predicting the severity of Duchenne muscular dystrophy: implications for treatment. Neurology. 77: 1858-1859. [ISSN: 0028-3878 - I.F.: 8,17].
• Trainotti L., Cagnin S., Forcato C., Bonghi C., Dhingra A., Koepke T., Prat L., Maldonado J., Silv H. (2012) Functional Genomics: Transcriptomics in Genetics, Genomics and Breeding of Stone Fruits Ed. by CRC Press Editor(s): Chittaranjan Kole, Clemson University, South Carolina, USA; Albert G. Abbott, Clemson University, South Carolina, USA [ISBN 9781578088010].
• Cagnin S., Cimetta E., Guiducci C., Martini P., Lanfranchi G. (2012) Overview of Micro- and Nano-Technology Tools for Stem Cell Applications: Micropatterned and Microelectronic Devices. Sensors 12, 15947-15982 [ISSN 1424-8220 – I.F.: 1,739].
• Pegoraro E, Hoffman E.P., Piva L, Gavassini B.F., Cagnin S., Ermani M., Bello L., Soraru G., Pacchioni B., Lanfranchi G., Angelini C., Kesari A., Lee I., Devaney J.M., Gordish-Dressman H., McDonald C. (2011) SPP1 genotype is a determinant of disease severity in Duchenne muscular dystrophy Neurology 76(3): 219-226. [ISSN: 0028-3878 - I.F.: 8,17]
• Martini P., Risso D., Sales G., Romualdi C., Lanfranchi G.*, Cagnin S.* (2011) Statistical test of Expression Pattern (STEPath): a new strategy to integrate different genomic information in gene expression and meta-analysis studies BMC Bioinformatics 12:92. * Co-corresponding authors. [ISSN 1471-2105 – I.F.: 3,43].
• Cagnin S., De Palma S., Martini P., Borsato C., Sales G., Vasso M. (2010) Characterization of altered process and protein modification in patients affected by inflammatory myopathies New Biotechnology 27:529. [ISSN: 1871-6784 – I.F.: 2,00].
• Cimetta E.*, Cagnin S.*, Volpatti A., Lanfranchi G., Elvassore N. (2010) Dynamic culture of bubble-confined cell arrays Biotechnol Prog. 26(1):220-31. *Equally contributed [E- ISSN: 1520-6033 - I.F.: 2,398].
• Biscontin A., Casara S., Cagnin S., Tombolan L., Rosolen A., Lanfranchi G., De Pittà C. (2010) New miRNA labeling method for bead-based quantification BMC Mol Biol. 16;11:44. [ISSN 1471-2199 - I.F.: 2,85].
• Cagnin S., Caraballo M., Guiducci C., Martini P., Ross M., SantAna M., Danley D., West T., Lanfranchi G. (2009) Overview of electrochemical DNA biosensors: new approaches to detect the expression of life Sensors 9(4): 3122-3148. [ISSN 1424-8220 - I.F.: 1,903].
• Cagnin S., Biscuola M., Patuzzo C., Trabetti E., Pasquali A., Faggian G., Iafrancesco M., Mazzucco A., Pignatta P.F., Lanfranchi G. (2009) Reconstruction and functional analysis of altered molecular pathways in atherosclerotic arteries BMC Genomics; 10(1):13. [ISSN 1471-2164 - I.F.: 4,18].
• Calura E., Cagnin S., Raffaello A., Lanfranchi G., Romualdi C. (2008) Meta-analysis of expression signatures of muscle atrophy: gene interaction networks in early and late stages BMC Genomics;9(1):630. [ISSN 1471-2164 - I.F.: 4,18].
• Bandiera L., Cellere G., Cagnin S., De Toni A., Zanoni E., Lanfranchi G., Lorenzelli L. (2007) A Fully electronic sensor for the measurement of cDNA hybridization kinetics Biosens Bioelectron. 22 (9-10):2108-14. [E-ISSN: 09565663 - I.F.: 5.429].
• Celegato B., Capitanio D., Pescatori M., Romualdi C., Pacchioni B., Cagnin S., Viganò A., Colantoni L., Begum S., Ricci E., Wait R., Lanfranchi G., Gelfi C. (2006) Parallel protein and transcript profiles of FSHD patient muscles correlate to the D4Z4 arrangement and reveal a common impairment of slow to fast fibre differentiation and a general deregulation of MyoD-dependent genes Proteomics 6: 5303-5321.
[P-ISSN: 1615-9853 – I.F.: 5.735].
• Campanaro S., De Pittà C., Celegato B., Millino C., Romualdi C., Bellin M., Pacchioni B., Trevisan S., Cagnin S., Tombolan L., Fanin M., Pegoraro E., Pescatori M., Valle G., Angelini C., Ricci E., Lanfranchi G. (2003) Application of a cDNA microarray for the analysis of muscular dystrophies and infantile leukaemias. Minerva Biotec.15: 235-244. [P-ISSN 1120-4826 - I. F.: 0,268].
• Millino C., Celegato B., Campanaro S., Romualdi C., Bellin M., Cagnin S., Valle G., Ricci E., Angelini C., Lanfranchi G. (2003). Expression profiling of neuromuscular disorders with a dedicated muscle microarray platform. Journal of Muscle Research and Cell Motility. [P-ISSN: 0142-4319 – I.F.: 1,657].
• Campanaro S., Romualdi C., De Pittà C., Fanin M., Celegato B., Pacchini B., Trevisan S., Laveder P., Toppo S., Cagnin S., Valle G., Angelini C., Lanfranchi G. (2002). Gene expression profiling in skeletal muscle using a dedicated microarray. Minerva Biotec. 14: 273-279. [P-ISSN 1120-4826 - I. F.: 0,268].
1 Protocol published
Isolation and Transcriptomic Profiling of Single Myofibers from Mice
Skeletal muscle is composed of different cells and myofiber types, with distinct metabolic and structural features. Generally, transcriptomic analysis of skeletal muscle is performed using whole muscle, resulting in average information as all cells ...
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