Elizabeth Avegno Physiology, Louisiana State University Health Sciences Center, United States, United States,
1 protocol

Nicholas W. Gilpin
  • Department of Physiology, Louisiana State University Health Sciences Center, USA, USA,
  • 1 Author merit

Education

PhD, Purdue University, U.S.A., 2005

Current position

Associate Professor, Physiology, LSU Health Sciences Center, U.S.A.

Publications

  1. Fucich, E.A., Mayeux, J.P., McGinn, M.A., Gilpin, N.W., Edwards, S., Molina, P.E. (in press) A novel role for the endocannabinoid system in ameliorating motivation for alcohol drinking and negative behavioral affect after traumatic brain injury in rats. Journal of Neurotrauma.
  2. Ninh, V.K., El Hajj, E.C., Mouton, A.J., El Hajj, M.C., Gilpin, N.W., Gardner, J.D. (in press) Chronic ethanol administration prevents compensatory cardiac hypertrophy in pressure overload. Alcoholism Clinical and Experimental Research. 
  3. Schreiber, A.L., McGinn, M.A., Edwards, S., Gilpin, N.W. (2019) Predator Odor Stress Blunts Alcohol Conditioned Aversion. Neuropharmacology 144:82-90. 
  4. Avegno, E.M., Lobell, T.D., Itoga, C.A., Baynes, B.B., Whitaker, A.M., Weera, M.M., Edwards, S., Middleton, J.W., Gilpin, N.W. (2018) Central amygdala circuits mediate hyperalgesia in alcohol-dependent rats. Journal of Neuroscience 38:7761-73. 
  5. Roltsch Hellard, E.A., Impastato, R.I., Gilpin, N.W. (2017) Intra-cerebral and intra-nasal melanocortin-4 receptor antagonist blocks withdrawal hyperalgesia in alcohol-dependent rats. Addiction Biology 22:692-701. 
  6. Schreiber, A.L., Lu, Y.-L., Baynes, B.B., Richardson, H. N., Gilpin, N.W. (2017) Corticotropin-releasing factor (CRF) in ventromedial prefrontal cortex mediates avoidance of a traumatic stress-paired context. Neuropharmacology 113:323-330. 
  7. McGinn, M.A., Paulsen, R.I., Itoga, C.A., Farooq, M.A., Reppel, J.E., Edwards, K.N., Whitaker, A.M., Gilpin, N.W., Edwards, S. (2016) Withdrawal from chronic nicotine exposure produces region-specific tolerance to alcohol-stimulated GluA1 phosphorylation. Alcoholism Clinical and Experimental Research 40:2537-47. 
  8. Itoga, C.A., Roltsch Hellard, E.A., Whitaker, A.M., Lu, Y.-L., Schreiber, A.L., Baynes, B.B., Baiamonte, B.A., Richardson, H.N., Gilpin, N.W. (2016) Traumatic Stress Promotes Hyperalgesia via Corticotropin-Releasing Factor-1 Receptor (CRFR1) Signaling in Central Amygdala. Neuropsychopharmacology 41:2463-72. 
  9. Mouton, A.J., Maxi, J.K., Souza-Smith, F.M., Bagby, G.J., Gilpin, N.W., Molina, P.E., Gardner, J.G. (2016) Alcohol vapor inhalation as a model of alcohol-induced organ disease. Alcoholism Clinical and Experimental Research 40:1671-8. 
  10. Di, S., Itoga, C.A., Fisher, M.O., Solomonow, J., Roltsch, E.A., Gilpin, N.W., Tasker, J.G. (2016) Acute stress suppresses synaptic inhibition and increases anxiety via endocannabinoid release in the basolateral amygdala. Journal of Neuroscience 36:8461-70. 
  11. Mouton, A.J., Ninh, V.K., El Hajj, E.C., Gilpin , N.W., Gardner, J.D. (2016) Exposure to Chronic Alcohol Accelerates Development of Wall Stress and Eccentric Remodeling in Rats with Volume Overload. Journal of Molecular and Cellular Cardiology 97:15-23. 
  12. Whitaker, A.M., Farooq, M.A., Edwards, S., Gilpin, N.W. (2015) Post-Traumatic Stress Avoidance is Attenuated by Corticosterone and Associated with Brain Levels of Steroid Receptor Co-Activator-1 in Rats. Stress 20:1-9. 
  13. Whitaker, A.M., Gilpin, N.W. (2015) Blunted hypothalamo-pituitary adrenal axis response to predator odor predicts high stress reactivity. Physiology & Behavior 147:16-22. 
  14. Teng, X.T., Katz, P.S., Maxi, J.M., Mayeux, J.P., Gilpin, N.W., Molina, P.E. (2015) Alcohol exposure after mild focal traumatic brain injury impairs neurological recovery and exacerbates localized neuroinflammation. Brain Behavior & Immunity 45:145-56. 
  15. Mayeux, J.P., Teng, X.T., Katz, P.S., Gilpin, N.W., Molina, P.E. (2015) Traumatic brain injury induces neuroinflammation and neuronal degeneration that is associated with escalated alcohol self-administration in rats. Behavioural Brain Research 279:22-30. 
  16. Vargas, W.M., Bengston, L., Gilpin, N.W., Whitcomb, B.W., Richardson, H.N. (2014) Alcohol binge drinking during adolescence or dependence during adulthood reduces prefrontal myelin in male rats. Journal of Neuroscience 34:14777-82. 
  17. El Hajj, E.C., Voloshenyuk, T.G., El Hajj, M.C., Mouton, A.J., Khoutorova, E., Hart, A.D., Baynes, B., Molina, P.E., Gilpin, N.W., Gardner, J.D. (2014) Alcohol modulation of MMP and TIMP expression in the heart favors collagen accumulation. Alcoholism: Clinical and Experimental Research 38:448-56. 
  18. Gilpin, N.W., Whitaker, A.M., Baynes, B., Abdel, A.Y., Weil, M.T., George O. (2014) Nicotine vapor inhalation escalates nicotine self-administration. Addiction Biology 19:587-92. 
  19. Gilpin, N.W., Roberto, M., Koob, G.F., Schweitzer, P. (2014) Kappa opioid receptor activation decreases inhibitory transmission and antagonizes alcohol effects in rat central amygdala. Neuropharmacology 77:294-302. 
  20. Baiamonte, B.A., Valenza, M., Roltsch, E.A., Whitaker, A.M., Baynes, B.B., Sabino, V., Gilpin, N.W. (2014) Nicotine dependence produces hyperalgesia: role of corticotropin-releasing factor-1 receptors (CRF1Rs) in the central amygdala (CeA). Neuropharmacology 77:217-223. 
  21. Roltsch, E.A., Baynes, B.B., Mayeux, J.P., Whitaker, A.M., Baiamonte, B.A., Gilpin, N.W. (2014) Predator Odor Stress Alters Corticotropin-Releasing Factor-1 Receptor (CRF1R)-Dependent Behaviors in Rats. Neuropharmacology 79:83-89. 
  22. Edwards, S., Baynes, B., Carmichael, C.Y., Zamora-Martinez, E.R., Barrus, M., Koob, G.F., Gilpin, N.W. (2013) Traumatic Stress Reactivity Promotes Excessive Alcohol Drinking and Alters the Balance of Prefrontal Cortex-Amygdala Activity. Translational Psychiatry 3:e296; doi:10.1038/tp.2013.70. 
  23. Kallupi, M., Vendruscolo, L.V., Carmichael, C.Y., George, O., Koob, G.F., Gilpin, N.W. (2013) Neuropeptide Y Y2R Blockade in the Central Amygdala Reduces Anxiety-Like Behavior but not Alcohol Drinking in Alcohol-Dependent Rats. Addiction Biology 19:755-7. 
  24. Gilpin, N.W., Karanikas, C.A., Richardson, H.N. (2012). Voluntary alcohol binge drinking early in adolescence alters drinking, anxiety, and amygdalar corticotropin releasing factor (CRF) cells in adult male rats. PLoS One 7: e31466. doi:10.1371/journal.pone.0031466. 
  25. Gilpin, N.W., Stewart, R.B., Badia-Elder, N.E. (2011) Effects of neuropeptide Y (NPY) and ethanol on arousal and anxiety-like behavior in alcohol-preferring (P) rats. Alcohol 45:137-45. 
  26. Gilpin, N.W., Misra, K., Herman, M.A., Cruz, M.T., Koob, G.F., Roberto, M. (2011) Neuropeptide Y opposes alcohol effects on GABA release in amygdala and blocks the transition to alcohol dependence. Biological Psychiatry 69:1091-9. 
  27. Gilpin, N.W., Wright, Jr., M.J., Dickinson, G., Vandewater, S.A., Price, J.U., Taffe, M.A. (2011) Influences of activity wheel access on the body temperature response to MDMA and methamphetamine. Pharmacology, Biochemistry & Behavior 99:295-300. 
  28. Roberto M., Cruz M.T., Gilpin N.W., Sabino V., Schweitzer P., Cottone P., Madamba S.M., Stouffer D., Zorrilla E.P., Koob G.F., Siggins G.R., Parsons L.H. (2010) Corticotropin Releasing Factor–Induced Amygdala Gamma-Aminobutyric Acid Release Plays a Key Role in Alcohol Dependence. Biological Psychiatry 67:831-9. 
  29. Gilpin, N.W., Koob, G.F. (2010) Effects of β-adrenoceptor antagonists on alcohol drinking by alcohol-dependent rats. Psychopharmacology 212:431-9. 
  30. Gilpin, N.W., Smith, A., Cole, M., Weiss, F., Koob, G.F., Richardson, H.N. (2009) Operant behavior and alcohol levels in blood and brain of alcohol-dependent rats. Alcoholism: Clinical and Experimental Research 33:2113-23. 
  31. Ji, D.*, Gilpin, N.W.*, Richardson, H.N., Rivier, C.L., Koob, G.F. (2008). Effects of naltrexone, duloxetine, and a CRF¬1 receptor antagonist on binge-like alcohol drinking in rats. Behavioral Pharmacology 19:1-12. 
  32. Gilpin, N.W., Misra K., Koob G.F. (2008). Neuropeptide Y in the central nucleus of the amygdala suppresses dependence-induced increases in alcohol drinking. Pharmacology, Biochemistry & Behavior 90:475-80. 
  33. Gilpin, N.W., Stewart, R.B., Badia-Elder, N.E. (2008). Neuropeptide Y administration into the amygdala suppresses ethanol drinking in alcohol-preferring (P) rats following multiple deprivations. Pharmacology, Biochemistry & Behavior 90:470-4. 
  34. Roberto, M., Gilpin, N.W., O’Dell, L.E., Morse, A.C., Siggins, G.R., Koob, G.F. (2008). Cellular and behavioral rationale for gabapentin treatment of alcohol dependence. Journal of Neuroscience 28:5762-71. 
  35. Gilpin, N.W., Richardson, H.N., Lumeng, L., Koob, G.F. (2008). Dependence-induced alcohol drinking by alcohol-preferring (P) rats and outbred Wistar rats. Alcoholism: Clinical and Experimental Research 32:1688-96. 
  36. Gilpin, N.W., Richardson, H.N., Koob, G.F. (2008). Effects of CRF1-receptor and opioid-receptor antagonists on dependence-induced increases in alcohol drinking by alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 32:1535-42. 
  37. Gilpin, N.W., Badia-Elder, N.E., Elder, R.L., Stewart, R.B. (2008). Schedule-induced polydipsia in lines of rats selectively bred for high and low ethanol preference. Behavior Genetics 38:515-24. 
  38. Gilpin, N.W., Stewart, R.B., Badia-Elder, N.E. (2008). Neuropeptide Y (NPY) suppresses ethanol responding in ethanol-abstinent, but not non-ethanol-abstinent, Wistar rats. Alcohol 42:541-51. 
  39. Gilpin, N.W., Stewart, R.B., Murphy, J.M., Badia-Elder, N.E. (2005). Sensitized effects of neuropeptide Y on multiple ingestive behaviors in P rats following ethanol abstinence. Pharmacology, Biochemistry & Behavior, 81:740-9. 
  40. Gilpin, N.W., Stewart, R.B., Elder, R.L., Kho, Y., Murphy, J.M., Li, T.-K., Badia-Elder, N.E. (2004). Sedative and motor-impairing effects of neuropeptide Y and ethanol in selectively-bred P and NP rats. Pharmacology, Biochemistry & Behavior 78:65-73.
  41. Gilpin, N.W., Stewart, R.B., Murphy, J.M., Li, T.-K., Badia-Elder, N.E. (2004). Neuropeptide Y in the paraventricular nucleus of the hypothalamus increases ethanol intake in high- and low-alcohol-drinking rats. Alcoholism: Clinical and Experimental Research 28:1492-8. 
  42. Gilpin, N.W., Stewart, R.B., Murphy, J.M., Li, T.-K., Badia-Elder, N.E. (2003). Neuropeptide Y reduces oral ethanol intake in alcohol-preferring (P) rats following a period of imposed ethanol abstinence. Alcoholism: Clinical and Experimental Research 27:787-94. 
1 Protocol published
Inducing Alcohol Dependence in Rats Using Chronic Intermittent Exposure to Alcohol Vapor
Authors:  Elizabeth M. Avegno and Nicholas W. Gilpin, date: 05/05/2019, view: 1008, Q&A: 0
Alcohol use disorder (AUD) is a significant public health and economic burden and is often characterized by repeated bouts of alcohol intoxication and withdrawal. Virtually all organ systems are impacted by chronic alcohol exposure. These effects ...
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