Davide Ragozzino Dept. of Physiology and Pharmacology "V. Erspamer", Sapienza University, Italy, Italy,
1 protocol

Patrizia Ratano Dept. of Physiology and Pharmacology "V. Erspamer", Sapienza University, Italy, Italy,
1 protocol

Barbara Cortese Sapienza University
1 protocol

Bernadette Basilico Dept of Physiology and Pharmacology, Sapienza University, Italy, Italy,
1 protocol

Silvia Di Angelantonio
  • Dept. of Physiology and Pharmacology "V. Erspamer", Sapienza University, Italy, Italy,
Research focus
  • Neuroscience
  • 1 Author merit


PhD in Biophysics, International School fo Advanced Studies SISSA, Italy, 2002

Current position

Assistant Professor, Physiology and Pharmacology, Sapienza University, Roma, Italy


  1. Basilico B, Pagani F, Grimaldi A, Cortese B, Di Angelantonio S, Weinhard L, Gross C, Limatola C, Maggi L, Ragozzino D. (2018) Microglia shape presynaptic properties at developing glutamatergic synapses. Glia. Nov 11. doi: 10.1002/glia.23508.  
  2. Grimaldi A, Brighi C, Peruzzi G, Ragozzino DA, Bonanni V, Limatola C, Ruocco G, Di Angelantonio S. (2018) Inflammation, neurodegeneration and protein aggregation in the retina as ocular biomarkers for Alzheimer’s disease in the 3xTg-AD mouse model. Cell Death and Disease. Jun 7;9(6):685. doi: 10.1038/s41419-018-0740-5. 
  3. De Santis R, Garone MG, Pagani F, de Turris V, Di Angelantonio S, Rosa A. (2018). Direct conversion of human pluripotent stem cells into cranial motor neurons using a piggyBac vector. Stem Cell Research 29, 189-196. doi:10.1016/j.scr.2018.04.012. 
  4. Grimaldi A, D'Alessandro G, Di Castro MA, Lauro C, Singh V, Pagani F, Sforna L, Grassi F, Di Angelantonio S, Catacuzzeno L, Wulff H, Limatola C, Catalano M. (2018) Kv1.3 activity perturbs the homeostatic properties of astrocytes in glioma. Scientific Reports May 16;8(1):7654. doi: 10.1038/s41598-018-25940-5. 
  5. Garofalo S, Porzia A, Mainiero F, Di Angelantonio S, Cortese B, Basilico B, Pagani F, Cignitti G, Chece G, Maggio R, Tremblay ME, Savage J, Bisht K, Esposito V, Bernardini G, Seyfried T, Mieczkowski J, Stepniak K, Kaminska B, Santoni A, Limatola C. (2017) Environmental stimuli shape microglial plasticity in glioma. eLife. Dec 29;
  6. pii: e33415. doi: 10.7554/eLife.33415. 6. Murana E, Pagani F, Basilico B, Sundukova M, Batti L, Di Angelantonio S, Cortese B, Grimaldi A, Francioso A, Heppenstall P, Bregestovski P, Limatola C, Ragozzino D. (2017) ATP release during cell swelling activates a Ca(2+)-dependent Cl(-) current by autocrine mechanism in mouse hippocampal microglia. Scientific Report Jun 23;7(1):4184. doi: 10.1038/s41598-017-04452-8.  
  7. Garofalo S, Grimaldi A, Chece G, Porzia A, Morrone S, Mainiero F, D'Alessandro G, Esposito V, Cortese B, Di Angelantonio S, Trettel F, Limatola C. (2017) The Glycoside Oleandrin Reduces Glioma Growth with Direct and Indirect Effects on Tumor Cells. Journal of Neuroscience. Apr 5;37(14):3926-3939. doi: 10.1523/JNEUROSCI.2296-16.2017. 
  8. Batti L, Sundukova M, Murana E, Pimpinella S, De Castro Reis F, Pagani F, Wang H, Pellegrino E, Perlas E, Di Angelantonio S, Ragozzino D, Heppenstall PA. (2016) TMEM16F Regulates Spinal Microglial Function in Neuropathic Pain States. Cell Reports Jun 21;15(12):2608-15. doi: 10.1016/j.celrep.2016.05.039.  
  9. Lenzi J, Pagani F, De Santis R, Limatola C, Bozzoni I, Di Angelantonio S, Rosa A (2016) Differentiation of control and ALS mutant human iPSCs into functional skeletal muscle cells, a tool for the study of neuromuscolar diseases. Stem Cell Research 17: 140-147 
  10. Grimaldi A, D'Alessandro G, Golia MT, Grössinger EM, Di Angelantonio S, Ragozzino D, Santoro A, Esposito V, Wulff H, Catalano M, Limatola C. (2016) KCa3.1 inhibition switches the phenotype of glioma-infiltrating microglia/macrophages. Cell Death and Disease Apr 7;7:e2174. doi: 10.1038/cddis.2016.73. 
  11. D'Alessandro G, Grimaldi A, Chece G, Porzia A, Esposito V, Santoro A, Salvati M, Mainiero F, Ragozzino D, Di Angelantonio S, Wulff H, Catalano M, Limatola C. (2016) KCa3.1 channel inhibition sensitizes malignant gliomas to temozolomide reatment. Oncotarget May 24;7(21):30781-96. doi: 10.18632/oncotarget.8761. 
  12. Di Angelantonio S, Bertollini C, Piccinin S, Rosito M, Trettel F, Pagani F, Limatola C, Ragozzino D (2015) Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R. Frontiers in Cellular Neuroscience Oct 12;9:409. doi: 10.3389/fncel.2015.00409. 
  13. Pagani F, Paolicelli RC, Murana E, Cortese B, Di Angelantonio S, Zurolo E, Guiducci E, Ferreira TA, Garofalo S, Catalano M, D'Alessandro G, Porzia A, Peruzzi G, Mainiero F, Limatola C, Gross CT, Ragozzino D (2015) Defective microglial development in the hippocampus of Cx3cr1 deficient mice. Frontiers in Cellular Neuroscience Mar 31;9:111. doi: 10.3389/fncel.2015.00111. 
  14. Di Angelantonio S, Murana E, Cocco S, Scala F, Bertollini C, Molinari MG, Lauro C, Bregestovski P, Limatola C, Ragozzino D (2014) A role for intracellular zinc in glioma alteration of neuronal chloride equilibrium. Cell Death and Disease Oct 30;5:e1501. doi: 10.1038/cddis.2014.437.  
  15. Catalano M, Lauro C, Cipriani R, Chece G, Ponzetta A, Di Angelantonio S, Ragozzino D, Limatola C (2013) CX3CL1 protects neurons against excitotoxicity enhancing GLT-1 activity on astrocytes. Journal of Neuroimmunology Oct 15;263(1-2):75-82. doi:10.1016/j.jneuroim.2013.07.020. 
  16. Bertollini C, Murana E, Mosca L, D'Erme M, Scala F, Francioso A, Catalano M, Limatola C, Bregestovski P, Di Angelantonio S*, Ragozzino D* (2012) Transient increase in neuronal chloride concentration by neuroactive aminoacids released from glioma cells. Frontiers in Molecular Neuroscience Nov 26;5:100. doi: 10.3389/fnmol.2012.00100. *equal contribution 
  17. Di Angelantonio S, Piccioni A, Moriconi C, Trettel F, Cristalli G, Grassi F, Limatola C (2011) Adenosine A2A receptor induces protein kinase A-dependent functional modulation of human (alpha)3(beta)4 nicotinic receptor. Journal of Physiology Jun 1;589(Pt 11):2755-66. doi: 10.1113/jphysiol.2011.207282.  
  18. Moriconi C, Di Angelantonio S, Piccioni A, Trettel F, Sabatelli M, Grassi F. (2011) Mutant human β4 subunit identified in amyotrophic lateral sclerosis patients impairs nicotinic receptor function. Pflugers Archives Feb;461(2):225-33. doi:10.1007/s00424-010-0905-2. 
  19. Di Angelantonio S, De Stefano ME, Piccioni A, Lombardi L, Gotti C, Paggi P (2011) Lack of dystrophin functionally affects α3β2/β4-nicotinic acethylcholine receptors in sympathetic neurons of dystrophic mdx mice. Neurobiology of Disease Feb;41(2):528-37. doi:10.1016/j.nbd.2010.10.024. 
  20. Piccinin S*, Di Angelantonio S*, Piccioni A, Volpini R, Cristalli G, Fredholm BB, Limatola C, Eusebi F, Ragozzino D (2010) CX3CL1-induced modulation at CA1 synapses reveals multiple mechanisms of EPSC modulation involving adenosine receptor subtypes. Journal of Neuroimmunology Jul 27;224(1-2):85-92. doi:10.1016/j.jneuroim.2010.05.012. *equal contribution 
  21. Trettel F, Di Angelantonio S, Limatola C, Ransohoff RM (2010) Chemokines and chemokine receptors in the nervous system. Rome, 24/25 October, 2009, 2nd workshop. Journal of Neuroimmunology Jul 27;224(1-2):1-7. doi:10.1016/j.jneuroim.2010.05.001 
  22. Sabatelli M, Eusebi F, Al-Chalabi A, Conte A, Madia F, Luigetti M, Mancuso I, Limatola C, Trettel F, Sobrero F, Di Angelantonio S, Grassi F, Di Castro A, Moriconi C, Fucile S, Lattante S, Marangi G, Murdolo M, Orteschi D, Del Grande A, Tonali P, Neri G, Zollino M. (2009) Rare missense variants of neuronal nicotinic acetylcholine receptor altering receptor function are associated with sporadic amyotrophic lateral sclerosis. Human Molecular Genetics Oct 15;18(20):3997-4006. doi:10.1093/hmg/ddp339.  
  23. Trettel F, Di Angelantonio S, Limatola C, Ransohoff RM. (2008) Chemokines and chemokine receptors in the nervous system Rome, 27/28 October, 2007. Journal of Neuroimmunology Jul 31;198(1-2):1-8. doi: 10.1016/j.jneuroim.2008.04.006.  
  24. Lauro C, Di Angelantonio S, Cipriani R, Sobrero F, Antonilli L, Brusadin V, Ragozzino D, Limatola C (2008) Activity of adenosine receptors type 1 Is required for CX3CL1-mediated neuroprotection and neuromodulation in hippocampal neurons. Journal of Immunology Jun 1;180(11):7590-6. PubMed PMID: 18490761. 
  25. Palma E, Ragozzino D, Di Angelantonio S, Mascia A, Maiolino F, Manfredi M, Cantore G, Esposito V, Di Gennaro G, Quarato P, Miledi R, Eusebi F (2007) The antiepileptic drug levetiracetam stabilizes the human epileptic GABAA receptors upon repetitive activation. Epilepsia Oct;48(10):1842-9. PubMed PMID: 17521347. 
  26. Ragozzino D*, Di Angelantonio S*, Trettel F, Bertollini C, Maggi L, Gross C, Charo IF, Limatola C, Eusebi F (2006) Chemokine fractalkine/CX3CL1 negatively modulates active glutamatergic synapses in rat hippocampal neurons. Journal of Neuroscience Oct 11;26(41):10488-98. PubMed PMID: 17035533. *equal contribution 
  27. Palma E, Amici M, Sobrero F, Spinelli G, Di Angelantonio S, Ragozzino D, Mascia A, Scoppetta C, Esposito V, Miledi R, Eusebi F. (2006) Anomalous levels of Cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory. Proceedings of the National Academy of Science USA (PNAS) May 30;103(22):8465-8. Erratum in: Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11814. PubMed PMID: 16709666; 
  28. Riganti L, Matteoni C, Di Angelantonio S, Nistri A, Gaimarri A, Sparatore F, Canu-Boido C, Clementi F, Gotti C (2005) Long-term exposure to the new nicotinic antagonist 1,2-bisN-cytisinylethane upregulates nicotinic receptor subtypes of SH-SY5Y human neuroblastoma cells. British Journal Pharmacology Dec;146(8):1096-109. PubMed PMID: 16273122; 
  29. Ragozzino D, Palma E, Di Angelantonio S, Amici M, Mascia A, Arcella A, Giangaspero F, Cantore G, Di Gennaro G, Manfredi M, Esposito V, Quarato PP, Miledi R, Eusebi F (2005) Rundown of GABA type A receptors is a dysfunction associated with human drug-resistant mesial temporal lobe epilepsy Proceedings of the National Academy of Science USA (PNAS) Oct 18;102(42):15219-23. PubMed PMID: 16217016 
  30. Limatola C, Lauro C, Catalano M, Ciotti MT, Bertollini C, Di Angelantonio S, Ragozzino D, Eusebi F (2005) Chemokine CX3CL1 protects rat hippocampal neurons against glutamate-mediated excitotoxicity. Journal of Neuroimmunology 2005 Sep;166(1-2):19-28. PubMed PMID: 16019082. 
  31. Federici M, Geracitano R, Tozzi A, Longone P, Di Angelantonio S, Bengtson CP, Bernardi G, Mercuri NB (2005) Trace amines depress GABA B response in dopaminergic neurons by inhibiting G-betagamma-gated inwardly rectifying potassium channels. Molecular Pharmacology Apr;67(4):1283-90. PubMed PMID: 15644497. 
  32. Di Angelantonio S, Bernardi G, Mercuri NB (2004) Methamidophos transiently inhibits neuronal nicotinic receptors of rat substantia nigra dopaminergic neurons via open channel block. Neuroscience Letters Oct 21;369(3):208-13. PubMed PMID:15464266. 
  33. Palma E, Ragozzino DA, Di Angelantonio S, Spinelli G, Trettel F, Martinez-Torres A, Torchia G, Arcella A, Di Gennaro G, Quarato PP, Esposito V, Cantore G, Miledi R, Eusebi F (2004) Phosphatase inhibitors remove the run-down of gamma-aminobutyric acid type A receptors in the human epileptic brain. Proceedings of the National Academy of Science USA (PNAS) Jul 6;101(27):10183-8. PubMed PMID: 15218107; PubMed Central PMCID: PMC454185. 
  34. Di Angelantonio S, Bernardi G, Mercuri NB (2004) Donepezil modulates nicotinic receptors of substantia nigra dopaminergic neurones. British Journal of Pharmacology Feb;141(4):644-52. PubMed PMID: 14744806 
  35. Di Angelantonio S, Giniatullin R, Costa V, Sokolova E, Nistri A (2003) Modulation of neuronal nicotinic receptor function by the neuropeptides CGRP and substance P on autonomic nerve cells. British Journal of Pharmacology Jul;139(6):1061-73. Review. PubMed PMID: 12871824 
  36. Di Angelantonio S, Matteoni C, Fabbretti E, Nistri A (2003) Molecular biology and electrophysiology of neuronal nicotinic receptors of rat chromaffin cells. European Journal of Neuroscience Jun;17(11):2313-22. PubMed PMID: 12814364. 
  37. Nistri A & Di Angelantonio S (2002) Enhancement of neuronal nicotinic receptor activity of rat chromaffin cells by a novel class of peptides. Annals of the New York Academy of Science (ANYAS) Oct;971:100-7. PubMed PMID: 12438099. 
  38. Di Angelantonio S, Costa V, Carloni P, Messori L, Nistri A (2002) A novel class of peptides with facilitating action on neuronal nicotinic receptors of rat chromaffin cells in vitro: functional and molecular dynamics studies. Molecular Pharmacology 2002 Jan;61(1):43-54. PubMed PMID: 11752205. 
  39. Di Angelantonio S & Nistri A (2001) Calibration of agonist concentrations applied by pressure pulses or via rapid solution exchanger. Journal of Neuroscience Methods Sep 30;110(1-2):155-61. PubMed PMID: 11564536. 
  40. Giniatullin RA, Sokolova EM, Di Angelantonio S, Skorinkin A, Talantova MV, Nistri A (2000) Rapid relief of block by mecamylamine of neuronal nicotinic acetylcholine receptors of rat chromaffin cells in vitro: an electrophysiological and modeling study. Molecular Pharmacology Oct;58(4):778-87. PubMed PMID: 10999948. 
  41. Di Angelantonio S, Nistri A, Moretti M, Clementi F, Gotti C (2000) Antagonism of nicotinic receptors of rat chromaffin cells by N,N,N-trimethyl-1-(4-trans-stilbenoxy)-2-propylammonium iodide: a patch clamp and ligand binding study. British Journal of Pharmacology 2000 Apr;129(8):1771-9. PubMed PMID: 10780985 
  42. Giniatullin R, Di Angelantonio S, Marchetti C, Sokolova E, Khiroug L, Nistri A (1999) Calcitonin gene-related peptide rapidly downregulates nicotinic receptor function and slowly raises intracellular Ca2+ in rat chromaffin cells in vitro. Journal of Neuroscience Apr 15;19(8):2945-53. PubMed PMID: 10191312.
1 Protocol published
Time-lapse Whole-field Fluorescence Imaging of Microglia Processes Motility in Acute Mouse Hippocampal Slices and Analysis
Microglia are the resident immune cells of the central nervous system (CNS). In the last year, the improvements in the transgenic mouse technologies and imaging techniques have shed light on microglia functions under physiological conditions. ...
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