Shengwen Calvin Li
  • Faculty, Children's Hospital of Orange County Research Insititute
Research focus
  • Cancer biology
  • Pediatric cancer, pediatric oncology, cancer stem cells, organoid culture, tissue scaffold, immunotherapy of cancer, cancer vaccine, single cell transcriptomes, tumor microenvironment.
  • 1 Author merit


PhD, Mount Sinai School of Medcine, New York, 1994

Lab information

Shengwen Calvin Li Laboratory


(Since 2018)
• Miao, Y., Chen, Z. and Li, S. C. (2019). Functional endoscopy techniques for tracking stem cell fate. Quant Imaging Med Surg 9(3): 510-520.
• Chen, X., Wen, Q., Stucky, A., Zeng, Y., Gao, S., Loudon, W. G., Ho, H. W., Kabeer, M. H., Li, S. C., Zhang, X. and Zhong, J. F. (2018). Relapse pathway of glioblastoma revealed by single-cell molecular analysis. Carcinogenesis 39(7): 931-936.
• Li, S. C. and Kabeer, M. H. (2018). Spatiotemporal switching signals for cancer stem cell activation in pediatric origins of adulthood cancer: Towards a watch-and-wait lifetime strategy for cancer treatment. World J Stem Cells 10(2): 15-22.
• Li, S. C., Stucky, A., Chen, X., Kabeer, M. H., Loudon, W. G., Plant, A. S., Torno, L., Nangia, C. S., Cai, J., Zhang, G. and Zhong, J. F. (2018). Single-cell transcriptomes reveal the mechanism for a breast cancer prognostic gene panel. Oncotarget 9(70): 33290-33301.
• Wu, J., Zhang, W., Ran, Q., Xiang, Y., Zhong, J. F., Li, S. C. and Li, Z. (2018). The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis. Stem Cells Int 2018: 1540148.
• Zeng, Y., Gao, L., Luo, X., Chen, Y., Kabeer, M. H., Chen, X., Stucky, A., Loudon, W. G., Li, S. C., Zhang, X. and Zhong, J. F. (2018). Microfluidic enrichment of plasma cells improves treatment of multiple myeloma. Mol Oncol 12(7): 1004-1011.
1 Protocol published
Precision Technique for Splenectomy Limits Mouse Stress Responses for Accurate and Realistic Measurements for Investigating Inflammation and Immunity
Authors:  Shengwen Calvin Li, Anthony D. Rangel and Mustafa H. Kabeer, date: 08/05/2019, view: 2979, Q&A: 0
Splenectomy in an animal model requires a standardized technique utilizing best practice to avoid variability which can result in adverse impact to the animal resulting in flawed physiologic responses simply due to technique rather than to the ...
1 Protocol reviewed
Generation of the Compression-induced Dedifferentiated Adipocytes (CiDAs) Using Hypertonic Medium

Current methods to obtain mesenchymal stem cells (MSCs) involve sampling, culturing, and expanding of primary MSCs from adipose, bone marrow, and umbilical cord tissues. However, the drawbacks are the limited numbers of total cells in MSC pools, and

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