Adrian M. Piliponsky
  • Associate professor, Pediatrics, University of Washington, 2018-
Research focus
  • -
  • 1 Author merit

Education

PhD, The Hebrew University of Jerusalem, Israel, 2003

Publications

• Piliponsky, A. M., Shubin, N. J., Lahiri, A. K., Truong, P., Clauson, M., Niino, K., Tsuha, A. L., Nedospasov, S. A., Karasuyama, H., Reber, L. L., Tsai, M., Mukai, K. and Galli, S. J. (2019). Basophil-derived tumor necrosis factor can enhance survival in a sepsis model in mice. Nat Immunol 20(2): 129-140.
• Altman, M. C., Lai, Y., Nolin, J. D., Long, S., Chen, C. C., Piliponsky, A. M., Altemeier, W. A., Larmore, M., Frevert, C. W., Mulligan, M. S., Ziegler, S. F., Debley, J. S., Peters, M. C. and Hallstrand, T. S. (2019). Airway epithelium-shifted mast cell infiltration regulates asthmatic inflammation via IL-33 signaling. J Clin Invest.
• Piliponsky, A. M., Acharya, M. and Shubin, N. J. (2019). Mast Cells in Viral, Bacterial, and Fungal Infection Immunity. Int J Mol Sci 20(12).
• Shubin, N. J., Navalkar, K., Simpson, D., Yager, T. D., Cermelli, S., Seldon, T., Sullivan, E., Zimmerman, J. J., Permut, L. C. and Piliponsky, A. M. Serum identified with an aptamer-based multiplexed proteomic approach. Crit Care Med. (In press).
• Gendrin, C., Shubin, N. J., Boldenow, E., Merillat, S., Clauson, M., Power, D., Doran, K. S., Abrink, M., Pejler, G., Rajagopal, L. and Piliponsky, A. M. (2018). Mast cell chymase decreases the severity of group B Streptococcus infections. J Allergy Clin Immunol 142(1): 120-129 e126.
• Piliponsky, A. M. and Romani, L. (2018). The contribution of mast cells to bacterial and fungal infection immunity. Immunol Rev 282(1): 188-197.
• Shubin, N. J., Glukhova, V. A., Clauson, M., Truong, P., Abrink, M., Pejler, G., White, N. J., Deutsch, G. H., Reeves, S. R., Vaisar, T., James, R. G. and Piliponsky, A. M. (2017). Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation. J Allergy Clin Immunol 139(1): 323-334.
• Nolin, J. D., Lai, Y., Ogden, H. L., Manicone, A. M., Murphy, R. C., An, D., Frevert, C. W., Ghomashchi, F., Naika, G. S., Gelb, M. H., Gauvreau, G. M., Piliponsky, A. M., Altemeier, W. A. and Hallstrand, T. S. (2017). Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen. JCI Insight 2(21).
• Piliponsky, A. M., Lahiri, A., Truong, P., Clauson, M., Shubin, N. J., Han, H. and Ziegler, S. F. (2016). Thymic Stromal Lymphopoietin Improves Survival and Reduces Inflammation in Sepsis. Am J Respir Cell Mol Biol 55(2): 264-274.
• Gendrin, C., Vornhagen, J., Ngo, L., Whidbey, C., Boldenow, E., Santana-Ufret, V., Clauson, M., Burnside, K., Galloway, D. P., Adams Waldorf, K. M., Piliponsky, A. M. and Rajagopal, L. (2015). Mast cell degranulation by a hemolytic lipid toxin decreases GBS colonization and infection. Sci Adv 1(6): e1400225.
• Lai, Y., Altemeier, W. A., Vandree, J., Piliponsky, A. M., Johnson, B., Appel, C. L., Frevert, C. W., Hyde, D. M., Ziegler, S. F., Smith, D. E., Henderson, Jr., WR, Gelb, M. H., Hallstrand, T. S. Increased density of intraepithelial mast cells in patients with exercise-induced bronchoconstriction regulated through epithelially derived thymic stromal lymphopoeitin and IL-33. J Allergy Clin Immunol 2013; S0091-6749(13)01473-5.
• Schafer, B., Piliponsky, A. M., Oka, T., Song, C. H., Gerard, N. P., Gerard, C., Tsai, M., Kalesnikoff, J. and Galli, S. J. (2013). Mast cell anaphylatoxin receptor expression can enhance IgE-dependent skin inflammation in mice. J Allergy Clin Immunol 131(2): 541-548 e541-549.
• Piliponsky, A. M., Chen, C. C., Rios, E. J., Treuting, P. M., Lahiri, A., Abrink, M., Pejler, G., Tsai, M. and Galli, S. J. (2012). The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis. Am J Pathol 181(3): 875-886.
• Akahoshi, M., Song, C. H., Piliponsky, A. M., Metz, M., Guzzetta, A., Abrink, M., Schlenner, S. M., Feyerabend, T. B., Rodewald, H. R., Pejler, G., Tsai, M. and Galli, S. J. (2011). Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice. J Clin Invest 121(10): 4180-4191.
• Lilla, J. N., Chen, C. C., Mukai, K., BenBarak, M. J., Franco, C. B., Kalesnikoff, J., Yu, M., Tsai, M., Piliponsky, A. M. and Galli, S. J. (2011). Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice. Blood 118(26): 6930-6938.
• Piliponsky, A. M., Chen, C. C., Grimbaldeston, M. A., Burns-Guydish, S. M., Hardy, J., Kalesnikoff, J., Contag, C. H., Tsai, M. and Galli, S. J. (2010). Mast cell-derived TNF can exacerbate mortality during severe bacterial infections in C57BL/6-KitW-sh/W-sh mice. Am J Pathol 176(2): 926-938.
• Galli, S. J., Tsai, M. and Piliponsky, A. M. (2008). The development of allergic inflammation. Nature 454(7203): 445-454.
• Piliponsky, A. M., Chen, C. C., Nishimura, T., Metz, M., Rios, E. J., Dobner, P. R., Wada, E., Wada, K., Zacharias, S., Mohanasundaram, U. M., Faix, J. D., Abrink, M., Pejler, G., Pearl, R. G., Tsai, M. and Galli, S. J. (2008). Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis. Nat Med 14(4): 392-398.
• Rios, E. J., Piliponsky, A. M., Ra, C., Kalesnikoff, J. and Galli, S. J. (2008). Rabaptin-5 regulates receptor expression and functional activation in mast cells. Blood 112(10): 4148-4157.
• Metz, M., Grimbaldeston, M. A., Nakae, S., Piliponsky, A. M., Tsai, M. and Galli, S. J. (2007). Mast cells in the promotion and limitation of chronic inflammation. Immunol Rev 217: 304-328.
• Nishimura, T., Myles, T., Piliponsky, A. M., Kao, P. N., Berry, G. J. and Leung, L. L. (2007). Thrombin-activatable procarboxypeptidase B regulates activated complement C5a in vivo. Blood 109(5): 1992-1997.
• Berent-Maoz, B., Piliponsky, A. M., Daigle, I., Simon, H. U. and Levi-Schaffer, F. (2006). Human mast cells undergo TRAIL-induced apoptosis. J Immunol 176(4): 2272-2278.
• Metz, M., Piliponsky, A. M., Chen, C. C., Lammel, V., Abrink, M., Pejler, G., Tsai, M. and Galli, S. J. (2006). Mast cells can enhance resistance to snake and honeybee venoms. Science 313(5786): 526-530.
• Puxeddu, I., Bader, R., Piliponsky, A. M., Reich, R., Levi-Schaffer, F. and Berkman, N. (2006). The CC chemokine eotaxin/CCL11 has a selective profibrogenic effect on human lung fibroblasts. J Allergy Clin Immunol 117(1): 103-110.
• Galli, S. J., Kalesnikoff, J., Grimbaldeston, M. A., Piliponsky, A. M., Williams, C. M. and Tsai, M. (2005). Mast cells as "tunable" effector and immunoregulatory cells: recent advances. Annu Rev Immunol 23: 749-786.
• Matsuda, K., Piliponsky, A. M., Iikura, M., Nakae, S., Wang, E. W., Dutta, S. M., Kawakami, T., Tsai, M. and Galli, S. J. (2005). Monomeric IgE enhances human mast cell chemokine production: IL-4 augments and dexamethasone suppresses the response. J Allergy Clin Immunol 116(6): 1357-1363.
• Puxeddu, I., Alian, A., Piliponsky, A. M., Ribatti, D., Panet, A. and Levi-Schaffer, F. (2005). Human peripheral blood eosinophils induce angiogenesis. Int J Biochem Cell Biol 37(3): 628-636.
• Grimbaldeston, M. A., Chen, C. C., Piliponsky, A. M., Tsai, M., Tam, S. Y. and Galli, S. J. (2005). Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo. Am J Pathol 167(3): 835-848.
• Maurer, M., Wedemeyer, J., Metz, M., Piliponsky, A. M., Weller, K., Chatterjea, D., Clouthier, D. E., Yanagisawa, M. M., Tsai, M. and Galli, S. J. (2004). Mast cells promote homeostasis by limiting endothelin-1-induced toxicity. Nature 432(7016): 512-516.
• Munitz, A., Piliponsky, A. M. and Levi-Schaffer, F. (2003). IgE-Independent Activation of Human Mast Cells Indicates their Role in the Late Phase Reaction of Allergic Inflammation. Cell Tissue Bank 4(1): 25-28.
• Puxeddu, I., Piliponsky, A. M., Bachelet, I. and Levi-Schaffer, F. (2003). Mast cells in allergy and beyond. Int J Biochem Cell Biol 35(12): 1601-1607.
• Maurer, M., Theoharides, T., Granstein, R. D., Bischoff, S. C., Bienenstock, J., Henz, B., Kovanen, P., Piliponsky, A. M., Kambe, N., Vliagoftis, H., Levi-Schaffer, F., Metz, M., Miyachi, Y., Befus, D., Forsythe, P., Kitamura, Y. and Galli, S. (2003). What is the physiological function of mast cells? Exp Dermatol 12(6): 886-910.
• Piliponsky, A. M., Gleich, G. J., Nagler, A., Bar, I. and Levi-Schaffer, F. (2003). Non-IgE-dependent activation of human lung- and cord blood-derived mast cells is induced by eosinophil major basic protein and modulated by the membrane form of stem cell factor. Blood 101(5): 1898-1904.
• Levi-Schaffer, F. and Piliponsky, A. M. (2003). Tryptase, a novel link between allergic inflammation and fibrosis. Trends Immunol 24(4): 158-161.
• Levi-Schaffer, F., Micera, A., Mechoulam, H., Puxeddu, I., Piliponsky, A. M., Zamir, E. and Aloe, L., Pe’er J. Nerve Growth Factor and eosinophils in inflammed juvenile conjunctival nevus. Invest Opththalmol Vis Sci 2002; 43: 1850-1856.
• Piliponsky, A. M., Gleich, G. J., Bar, I. and Levi-Schaffer, F. (2002). Effects of eosinophils on mast cells: a new pathway for the perpetuation of allergic inflammation. Mol Immunol 38(16-18): 1369.
• Smith, S. J., Piliponsky, A. M., Hartman, M. and Levi-Schaffer, F. Stem cell factor: a paradigm between mast cells, eosinophils and fibroblasts. All Clin Immunol Int 2002; 14: 52-59
• Smith, S. J., Piliponsky, A. M., Rosenhead, F., Elchalal, U., Nagler, A. and Levi-Schaffer, F. (2002). Dexamethasone inhibits maturation, cytokine production and Fc epsilon RI expression of human cord blood-derived mast cells. Clin Exp Allergy 32(6): 906-913.
• Piliponsky, A. M., Pickholtz, D., Gleich, G. J. and Levi-Schaffer, F. (2001). Human eosinophils induce histamine release from antigen-activated rat peritoneal mast cells: a possible role for mast cells in late-phase allergic reactions. J Allergy Clin Immunol 107(6): 993-1000.
• Hartman, M., Piliponsky, A. M., Temkin, V. and Levi-Schaffer, F. (2001). Human peripheral blood eosinophils express stem cell factor. Blood 97(4): 1086-1091.
• Spoelstra, F. M., Postma, D. S. and Kauffman, H. F. (2001). Mutual activation of pulmonary fibroblasts and eosinophils, and modulation by drugs in relation to asthma. Clin Exp Allergy 31(6): 808-816.
• Touitou, E., Godin, B., Dayan, N., Weiss, C., Piliponsky, A. and Levi-Schaffer, F. (2001). Intracellular delivery mediated by an ethosomal carrier. Biomaterials 22(22): 3053-3059.
• Piliponsky, A. M. and Levi-Schaffer, F. (2000). Regulation of apoptosis in mast cells. Apoptosis 5(5): 435-441.
• Piliponsky, A. M., Pickholtz, D., Gleich, G. J. and Levi-Schaffer, F. (1999). Eosinophils activate mast cells to release histamine. Int Arch Allergy Immunol 118(2-4): 202-203.
1 Protocol published
Adoptive Transfer of Basophils Enriched from Mouse Spleen
Authors:  Adrian M. Piliponsky and Stephen J. Galli, date: 11/05/2019, view: 76, Q&A: 0
CD49b is a member of the integrin family, expressed on basophils, natural killer (NK) cells and a subset CD4+ T cells in the spleen. This protocol describes the adoptive transfer of basophil-enriched CD49b+ cells obtained from ...
We use cookies on this site to enhance your user experience. By using our website, you are agreeing to allow the storage of cookies on your computer.