Laura Ferraiuolo Neuroscience, University of Sheffield
1 protocol

Matthew Stopford Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield,2016-2019
1 protocol

Scott P. Allen
  • Lecturer, Neuroscience, University of Sheffield, 2009-2019
Research focus
  • Neuroscience
  • 1 Author merit

Education

Ph.D., University of Manchester, UK, 2004

Publications

Recent Publications
• Allen SP*, Hall B, Castelli LM, Francis L, Woof R, Siskos AP, Kouloura E, Gray E, Thompson AG, Talbot K, Higginbottom A, Myszczynska M, Allen CF, Stopford MJ, Hemingway J, Bauer CS, Webster CP, De Vos KJ, Turner MR, Keun HC, Hautbergue GM, Ferraiuolo L, Shaw P. Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis. Brain 2019; 142: 586–605.
• Feng S, Bowden N, Fragiadaki M, Souilhol C, Hsiao S, Mahmoud M, Allen SP*, Pirri D, Ayllon BT, Akhtar S, Thompson AAR, Jo H, Weber C, Ridger V, Schober A, Evans PC. Mechanical Activation of Hypoxia- Inducible Factor 1 alpha Drives Endothelial Dysfunction at Atheroprone Sites. Arteriosclerosis, Thrombosis, and Vascular Biology. 2017; 37: 2087-2101.
• Allen SP*, Duffy L, Shaw PJ, and Grierson AJ. Altered age related changes in bioenergetic properties and mitochondrial morphology in fibroblasts from sporadic amyotrophic lateral sclerosis (SALS). Neurobiol. Aging. 2015; 36: 2893-903.
• Raman R and Allen SP*, Goodall EF, Kramer S, Ponger LL, Heath PR, Milo M, Hollinger HC, Walsh T, Highley JR, Olpin S, McDermott CJ, Shaw PJ, Kirby J. Gene expression signatures in motor neurone disease fibroblasts reveal dysregulation of metabolism, hypoxia-response and RNA processing functions. Neuropathol. Appl. Neurobiol. 2015; 41: 201-26.
• Allen SP*, Rajan S, Duffy L, Mortiboys H, Higginbottom A, Grierson AJ, Shaw PJ. Superoxide dismutase 1 mutation in a cellular model of amyotrophic lateral sclerosis shifts energy generation from oxidative phosphorylation to glycolysis. Neurobiol. Aging. 2014; 35:1499-509.
• Richardson K and Allen SP*, Mortiboys H, Grierson AJ, Wharton SB, Ince PG, Shaw PJ, Heath P. The effect of SOD1 mutation on cellular bioenergetic profile and viability in response to oxidative stress and influence of mutation-type. PLoS One. 2013; 28: e68256.
• Mead RJ, Higginbottom A, Allen SP*, Kirby J, Bennett E, Barber SC, Heath PR, Coluccia A, Patel N, Gardner I, Brancale A, Grierson AJ, Shaw PJ. S [+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis. Free Radic. Biol. Med. 2013; 61: 438-52.
1 Protocol published
A High-throughput and Pathophysiologically Relevant Astrocyte-motor Neuron Co-culture Assay for Amyotrophic Lateral Sclerosis Therapeutic Discovery
Authors:  Matthew J. Stopford, Scott P. Allen and Laura Ferraiuolo, date: 09/05/2019, view: 643, Q&A: 0
Amyotrophic lateral sclerosis (ALS) is an adult onset neurological disorder characterized by loss of motor neurons leading to progressive muscle wasting and eventually death. Astrocytes play a key role in disease pathogenesis. However, the ability ...
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