Christina Banti University of Ioannina Ioannina
2 protocols

Sotiris K. Hadjikakou
  • Prpfessor, University of Ioannina Ioannina
Research focus
  • Biochemistry
  • · Biological Inorganic Chemistry or Inorganic Biochemistry

    · Metallomics

    · Conjugation of Metals with Drugs (CoMeD’s) against cancer cells or microbes

    · Small Bioactive Molecules (SBaM’s) against cancer cells or microbial cultures

    · Discovery and development of new therapeutic anticancer agents;

    · Encapsulated CoMeD's or SBaM's into micelles, hydrogels or natural resins with enhanced bioactivity;

    · Active medical devices (conduct lens, medical gauzes, etc)



    · New CoMeD’s or SMaM’s which bind to biological targets modulating their function.

    · DNA - CoMeD’s or SMaM’s interaction.

    · Enzymes - CoMeD’s or SMaM’s interaction

    · Photoactivated Anticancer Compunds.

    · Study of the mechanism of action of anti-thyroid drugs.
  • 2 Author merit

Education

PhD, Aristotle Univeristy of Thessaloniki Greece, 1992

Lab information

Sotiris Hadjikakou Lab
http://users.uoi.gr/shadjika/Hadjikakou_1/Hadjikakou_01.htm

2 Protocols published
Evaluation of Toxicity with Brine Shrimp Assay
Authors:  Christina N. Banti and Sotiris K. Hadjikakou, date: 01/20/2021, view: 998, Q&A: 0

The in vivo toxicity of new metallodrugs either as Small Bioactive Molecules (SBAMs) or Conjugates of Metals with Drugs (CoMeDs) or their hydrogels such as with hydroxyethyl-methacrylate (HEMA) (pHEMA@SBAMs or pHEMA@CoMeDs) are evaluated by the

...
Evaluation of Genotoxicity by Micronucleus Assay in vitro and by Allium cepa Test in vivo
Authors:  Christina N. Banti and Sotiris K. Hadjikakou, date: 07/20/2019, view: 4549, Q&A: 0
The in vitro and in vivo genotoxicity of new metallodrugs either as Small Bioactive Molecules (SBAMs) or Conjugates of Metals with Drugs (CoMeDs) is evaluated by the micronucleus test and the Allium cepa assay, ...
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