Christina Banti Deaprtment of Chemisty, University of Ioannina, Ioannina
1 protocol

Sotiris K. Hadjikakou
  • Prpfessor, Deaprtment of Chemisty, University of Ioannina, Ioannina
Research focus
  • -
  • · Biological Inorganic Chemistry or Inorganic Biochemistry

    · Metallomics

    · Conjugation of Metals with Drugs (CoMeD’s) against cancer cells or microbes

    · Small Bioactive Molecules (SBaM’s) against cancer cells or microbial cultures

    · Discovery and development of new therapeutic anticancer agents;

    · Encapsulated CoMeD's or SBaM's into micelles, hydrogels or natural resins with enhanced bioactivity;

    · Active medical devices (conduct lens, medical gauzes, etc)



    · New CoMeD’s or SMaM’s which bind to biological targets modulating their function.

    · DNA - CoMeD’s or SMaM’s interaction.

    · Enzymes - CoMeD’s or SMaM’s interaction

    · Photoactivated Anticancer Compunds.

    · Study of the mechanism of action of anti-thyroid drugs.
  • 1 Author merit

Education

PhD, Aristotle Univeristy of Thessaloniki Greece, 1992

Lab information

Sotiris Hadjikakou Lab
http://users.uoi.gr/shadjika/Hadjikakou_1/Hadjikakou_01.htm

Publications

(Since 2015)
· Evaluation of Genotoxicity by Micronucleus Assay in vitro and by Allium cepa Test in vivo. Christina N. Banti and Sotiris K. Hadjikakou, Bioprotocols, 2019 accepted for publication
· Synthesis, Characterization, Biological Evaluation and Docking Study of Novel Antimony(III) Iodide Complexes with Tetramethylthiourea and N-ethylthiourea. I.I. Ozturk, S. Yarar, M.G. Eser, D. Ceyhan, C.N. Banti, S.K. Hadjikakou, M. Manoli, E. Moushi, A.J. Tasiopoulos, Inorganica Chimica Acta 491 (2019) 14–24.
· Anti-proliferative and antitumor activity of organotin compounds; The progress of last decade. Christina N. Banti, Sotiris K. Hadjikakou, Tuba Sismanoglu and Nick Hadjiliadis, 2019, Journal of Inorganic Biochemistry 194 (2019) 114–152.
· Diclofenac conjugates with biocides through silver(I) ions (CoMeD’s); Development of an optimized reliable regression model for the evaluation of antiproliferative metallodrugs. Christina N. Banti, Antonios G. Hatzidimitriou, Nikolaos Kourkoumelis, Sotiris K. Hadjikakou, J Inorg. Biochem. 194 (2019) 7–18.
· NSAIDs in breast cancer chemotherapy; Antimony(V) salicylate a strong covalent DNA binder. N.M. Polychronis, C.N. Banti, C.P. Raptopoulou, V. Psycharis, N. Kourkoumelis, S.K. Hadjikakou, Inorganica Chimica Acta 489 (2019) 39–47.
· The periodic table of urea derivative; Small molecules of zinc(II) and nickel(II) of diverse antimicrobial and antiproliferative applications. Christina N. Banti, Mehmet Poyraz, I. Sainis, Musa Sari, G. Rossos, N. Kourkoumelis, and Sotiris K. Hadjikakou, Molecular Diversity, 2019, Accepted for publication
· Preface to “A Commemorative Issue in Honour of Professor Nick Hadjiliadis: Metal Complex Interactions with Nucleic Acids and/or DNA”. Christina N. Banti and Sotiris K. Hadjikakou, Int. J. Mol. Sci. 2018, 19, 3815; doi:10.3390/ijms19123815
· Prokaryotic diversity and abundance in the sediments of an eutrophic ancient european lake (lake pamvotis - Greece). Anastasia Touka; Katerina Vareli; Maria Igglezou; Nikolaos Monokrousos; Dimitrios Alivertis; John M Halley; Sotiris Hadjikakou; Stathis Frillingos; Ioannis Sainis Open Journal of Ecology, 2018, 8, 537-578
· Bismuth(III) Bromide Complexes of Thioamides: Synthesis, Characterization and Cytotoxic Properties. M. Cakmak, I.I. Ozturk, C.N. Banti, M. Manoli, E. Moushi, A.J. Tasiopoulos, A.M. Grześkiewicz, M. Kubicki, S.K. Hadjikakou, Main Group Met. Chem. 41, 2018, 143-154, 2018; aop, https://doi.org/10.1515/mgmc-2018-0035
· A water - soluble silver(I) formulation as an effective disinfectant of contact lenses cases. M.P. Chrysouli, C.N. Banti, I. Milionis, D. Koumasi, I. Sainis, C.P. Raptopoulou, V. Psycharis, S.K. Hadjikakou, Materials Science & Engineering C 93 (2018) 902–910
· Polymeric assemblies from organotins acetate against DNA with possible implementation towards human breast cancer. G.K. Latsis, C.N. Banti, C. Papatriantafyllopoulou, N. Panayiotou, Α. Tasiopoulos, Α. Douvalis, T. Baka3, S.K. HadjikakouInt. J. Mol. Sci. 2018, 19, 2055; doi:10.3390/ijms19072055
· Silver ciprofloxacin (CIPAG): a successful combination of antibiotics in inorganic-organic hybrid for the development of novel formulations based on chemically modified commercially available antibiotics. I. Milionis, C.N. Banti, I. Sainis, C.P. Raptopoulou, V. Psycharis, N. Kourkoumeli and S.K. Hadjikakou, Journal of Biological Inorganic Chemistry, 2018, (2018) 23:705–723 https://doi.org/10.1007/s00775-018-1561-9
· Cytotoxic effect, antitumour activity and toxicity of organotin derivatives with ortho- or para- hydroxy-benzoic acids. Maria S Agiorgiti; Angelos Evangelou; Patra Vezyraki; Sotiris Hadjikakou; Vasiliki Kalfakakou; Ioannis Tsanaktsidis; Anna Batistatou; John Zelovitis; Yannis V Simos; Vasilios Ragos; Spyridon Karkabounas; Dimitrios Peschos, Medicinal Chemistry Research (2018) 27:1122–1130
· Silver complex of salicylic acid and its hydrogel-cream in wound healing chemotherapy. Maria-Eleni K. Stathopoulou, Christina N. Banti, Nikolaos Kourkoumelis, Antonis Hatzidimitriou, Sotiris K. Hadjikakou, Journal of Inorganic Biochemistry 181 (2018) 41–55
· New metalo-therapeutics of NSAIDs against human breast cancer cells. Christina N. Banti, Constantina Papatriantafyllopoulou, Anastasios J. Tasiopoulos and Sotiris K. Hadjikakou, European Journal of Medicinal Chemistry 143 (2018) 1687-1701
· Chloro(triphenylphosphine)gold(I) a forefront reagent in gold chemistry as apoptotic agent for cancer cells. M.P. Chrysoul, C.N. Banti, N. Kourkoumelis, N. Panayiotou, A.J. Tasiopoulos, S.K. Hadjikakou, Journal of Inorganic Biochemistry 179 (2018) 107–120
· Synthesis, Characterization and Cytostatic Properties of Bismuth(III) Chloride Complexes with Heterocyclic Thioamides; A survey for Structure Activity Relationship. S. Yarar, I.I. Ozturk, C.N. Banti, N. Panagiotou, C. Papatriantafyllopoulou, M. Manoli, M.J. Manos, A.J. Tasiopoulos, S.K. Hadjikakou, Inorganica Chemica Acta,471, 2018, 23-33
· Innovative material containing the natural product curcumin, with enhanced antimicrobial properties for active packaging. A. Papadimitriou, I. Ketikidis, M.K. Stathopoulou, C.N. Banti, C. Papachristodoulou, L. Zoumpoulakis, S. Agathopoulos, G.V. Vagenas, S.K. Hadjikakou, Materials Science & Engineering C 84 (2017) 118–122
· Synthesis, characterization and biological activities of copper(II) complex of 2-Benzimidazolyl-urea and the nitrate salt of 2-Benzimidazolyl-urea. Mehmet Poyraz, Musa Sari, Christina N. Banti and Sotiris K. Hadjikakou, Journal of Molecular Structure 1146 (2017) 809-813
· N-(4-hydroxyphenyl)acetamide against di-iodine towards polyiodide dianion. Christina N. Banti, Nick Kourkoumelis, Catherine P. Raptopoulou, Vassilis Psycharis, Sotiris K. Hadjikakou, New J. Chem., 2017, 41, 5555-5564.
· Docking and structure activity relationship studies of NSAIDs. What does molecular docking reveal about IC50? Chrysoula Mikra, Georgios Rossos, Sotirios K. Hadjikakou, Nikolaos Kourkoumelis, Letters in Drug Design & Discovery, 2017, 14, 949-958; DOI: 10.2174/1570180814666161207143231
· Synthesis characterization and biological activity of mixed ligand silver(I) complex of 2-Benzimidazolyl-urea and triphenylphosphine. Mehmet Poyraz, Halil Berber, Christina N. Banti, Nikolaos Kourkoumelis, Manolis J. Manos and Sotiris K. Hadjikakou, Polyhedron 128 (2017) 95–103
· QSAR studies on antimony(III) halide complexes with N-substituted thioureas derivatives. I.I. Ozturk, S. Yarar, C.N. Banti, N. Kourkoumelis, M.P. Chrysouli, M. Manol, A. J. Tasiopoulos, S.K. Hadjikakou, Polyhedron 123 (2017) 152–161
· Platinum(II)-thiosemicarbazone metal-drugs may be overcome cell resistance through glutathione; Assessment of their activity against human adenocarcinoma cells. M. Poyraz, S. Demirayak, C.N. Banti, M.J Manos, N Kourkoumelis and S.K. Hadjikakou, J Coord Chem., 2016 69, 3560–3579
· Silver(I) complexes of methyl xanthate against human adenocarcinoma breast cancer cells. Christina N. Banti, Nikolaos Kourkoumelis , Constantinos G. Tsiafoulis, Stavroula Skoulika, Sotiris K. Hadjikakou Polyhedron (2017), pp. 115-122 DOI information: 10.1016/j.poly.2016.09.056
· Structural, photolysis and biological studies of novel mixed metal Cu(I)-Sb(III) mixed ligand complexes. V. Tsiatouras, C.N. Banti, A.M. Grześkiewicz, G. Rossos, N. Kourkoumelis, M. Kubicki and S.K. Hadjikakou, 2016 Journal of Photochemistry & Photobiology, B: Biology 163 (2016) 261-268
· Nimesulide silver metallodrugs, containing the mitochondriotropic, triaryl derivatives of pnictogen; Anticancer activity against human breast cancer cells. Christina N. Banti, Constantina Papatriantafyllopoulou, Maria Manoli, Anastasios J. Tasiopoulos and Sotiris K. Hadjikakou, Inorg. Chem., 2016, 55 (17), pp 8681–8696.
· Non Steroidal Anti-Inflammatory Drugs (NSAIDs) as ligands in metal complexes and their effect on the cellular level. Christina N. Banti and Sotiris K. Hadjikakou, European Journal of Inorganic Chemistry 2016 (19), pp. 3048-3071
· Novel bismuth compounds; Synthesis, characterization and biological activity against human adenocarcinoma cell lines. M. Arda, I.I. Ozturk, C.N. Banti, N. Kourkoumelis, M. Manoli, A.J. Tasiopoulos, S. K. Hadjikakou 2016 RSC Adv., 2016, 6, 29026–29044
· Addition of Tetraethylthiuram Disulfide to Antimony(III) Iodide; Synthesis, Characterization and Biological Activity. O.S. Urgut, I.I. Ozturk, C.N. Banti, N. Kourkoumelis, M. Manoli, A.J. Tasiopoulos, S.K. Hadjikakou, Inorganica Chimica Acta 443 (2016) 141–150
· New antibacterial, non-genotoxic materials, derived from the functionalization of the anti-thyroid drug methimazole with silver ions. I. Sainis, C.N. Banti, A.M. Owczarzak, L. Kyros, N. Kourkoumelis, M. Kubicki, S.K. Hadjikakou, Journal of Inorganic Biochemistry 160 (2016) 114–124
· New Antimony(III) Halide Complexes with Dithiocarbamate Ligands Derived from Thiuram Degradation: The Effect of the molecule's close contacts on in vitro cytotoxic activity. O.S. Urgut, I.I. Ozturk, C.N. Banti, N. Kourkoumelis, M. Manoli, A.J. Tasiopoulos, S. K. Hadjikakou, Materials Science and Engineering C 58 (2016) 396–408.
· Recent advances on antimony(III/V) compounds with potential activity against tumor cells. S.K. Hadjikakou, I.I. Ozturk, C.N. Banti, N. Kourkoumlis and N. Hadjiliadis, J. Inrog Biochem 2015, 153, 293–305.
· Novel mixed metal Ag(I)-Sb(III)-metallotherapeutics of the NSAIDs, aspirin and salicylic acid. Enhancement of their solubility and bioactivity by using the surfactant CTAB. E.I. Gkaniatsou, C.N. Banti, N. Kourkoumelis, S. Skoulika M. Manoli, A.J. Tasiopoulos and S.K. Hadjikakou, J. Inrog Biochem 150, 2015, 108-119
· Rational Drug Design Paradigms: The Odyssey for designing better Drugs. T. Kellici, D. Ntountaniotis, E. Vrontaki, G. Liapakis, P. Minakakis, G. Kokotos, S. Hadjikakou, A.G. Tzakos, A. Afantitis, G. Melagraki, V. Di Marzo, T. Mavromoustakos, Combinatorial Chemistry & High Throughput Screening, 2015, 18, 238-256.
· The Healing Effect of Four Different Silver Complexes on Full-thickness Skin Burns in a Rat Model. E. Gouma, A. Batistatou, I.I. Verginadis, Y.V. Simos, L. Kyros, S.K. Hadjikakou, S.Ch. Karkabounas, A.M. Evangelou, VN. Ragos, D. Peschos, in vivo, 2015, 29: 55-64
· Mono-nuclear cis-Pd(II) chloride complex of the thio-nucleotide analogue 5-methyl-thiouracil and its biological activity. C.N. Banti, D. Charalampou, N. Kourkoumelis, A. M. Owczarzak, M. Kubicki, S. K. Hadjikakou, N. Hadjilaidis. Polyhedron, 2015, 87, 251-258
· Silver(I) compounds of the anti-inflammatory agents salicylic acid and p-hydroxyl-benzoic acid which modulate cell function. C.N. Banti, A.D. Giannoulis, N. Kourkoumelis, A.M. Owczarzak, M. Kubicki , S.K. Hadjikakou Journal of Inorganic Biochemistry 142 (2015) 132–144
1 Protocol published
Evaluation of Genotoxicity by Micronucleus Assay in vitro and by Allium cepa Test in vivo
Authors:  Christina N. Banti and Sotiris K. Hadjikakou, date: 07/20/2019, view: 1135, Q&A: 0
The in vitro and in vivo genotoxicity of new metallodrugs either as Small Bioactive Molecules (SBAMs) or Conjugates of Metals with Drugs (CoMeDs) is evaluated by the micronucleus test and the Allium cepa assay, ...
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