Agnieszka A. Wendorff
  • Research scientist, Institute for Cancer Genetics, Columbia University, New York
Research focus
  • -
  • The Ferrando Laboratory is endeavoring to understand the molecular mechanisms that promote and sustain the malignant proliferation and survival of leukemic cells.
  • 1 Author merit

Education

Ph.D., École polytechnique fédérale de Lausanne, 2010

Lab information

Adolfo A Ferrando, Columbia University, New York, NY, USA
http://ferrandolab.org/

Publications

http://ferrandolab.org/publications.html
• Belver, L., Yang, A. Y., Albero, R., Herranz, D., Brundu, F. G., Quinn, S. A., Perez-Duran, P., Alvarez, S., Gianni, F., Rashkovan, M., Gurung, D., Rocha, P. P., Raviram, R., Reglero, C., Cortes, J. R., Cooke, A. J., Wendorff, A. A., Cordo, V., Meijerink, J. P., Rabadan, R. and Ferrando, A. A. (2019). GATA3-Controlled Nucleosome Eviction Drives MYC Enhancer Activity in T-cell Development and Leukemia. Cancer Discov 9(12): 1774-1791.
• Wendorff, A. A., Quinn, S. A., Rashkovan, M., Madubata, C. J., Ambesi-Impiombato, A., Litzow, M. R., Tallman, M. S., Paietta, E., Paganin, M., Basso, G., Gastier-Foster, J. M., Loh, M. L., Rabadan, R., Van Vlierberghe, P. and Ferrando, A. A. (2019). Phf6 Loss Enhances HSC Self-Renewal Driving Tumor Initiation and Leukemia Stem Cell Activity in T-ALL. Cancer Discov 9(3): 436-451.
• Herranz, D., Ambesi-Impiombato, A., Sudderth, J., Sanchez-Martin, M., Belver, L., Tosello, V., Xu, L., Wendorff, A. A., Castillo, M., Haydu, J. E., Marquez, J., Mates, J. M., Kung, A. L., Rayport, S., Cordon-Cardo, C., DeBerardinis, R. J. and Ferrando, A. A. (2015). Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia. Nat Med 21(10): 1182-1189.
• Herranz, D., Ambesi-Impiombato, A., Palomero, T., Schnell, S. A., Belver, L., Wendorff, A. A., Xu, L., Castillo-Martin, M., Llobet-Navas, D., Cordon-Cardo, C., Clappier, E., Soulier, J. and Ferrando, A. A. (2014). A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia. Nat Med 20(10): 1130-1137.
• Wendorff, A. A., Koch, U., Wunderlich, F. T., Wirth, S., Dubey, C., Bruning, J. C., MacDonald, H. R. and Radtke, F. (2010). Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation. Immunity 33(5): 671-684.
1 Protocol published
Modeling NOTCH1 driven T-cell Acute Lymphoblastic Leukemia in Mice
Authors:  Agnieszka A. Wendorff and Adolfo A. Ferrando, date: 05/20/2020, view: 439, Q&A: 0
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy that arises from transformation of T-cell primed hematopoietic progenitors. Although T-ALL is a heterogenous and molecularly complex disease, more than 65% of ...
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