Pierre-Louis Tharaux Institut National de la Santé et de la Recherche Médicale
1 protocol

Carole Henique Institut Mondor de Recherche Biomédicale , Inserm U955/University Paris Est Créteil, France
1 protocol

Olivia Lenoir
  • 1 Author merit


PhD, University Paris 7, France, 2011

Current position

Researcher, PAris Cariovascular Center, Inserm U970, France


  1. Czopek A, Moorhouse R, Guyonnet L, Farrah T, Lenoir O, Owen E, van Bragt J, Costello HM, Menolascina F, Baudrie V, Webb DJ, Kluth DC, Bailey MA, Tharaux PL, Dhaun N. A novel role for myeloid endothelin-B receptors in hypertension. Eur Heart J. 2019 Mar 1;40(9):768-784. 
  2. Lenoir O, Gaillard F, Lazareth H, Robin B, Tharaux PL. Hmox1 Deficiency Sensitizes Mice to Peroxynitrite Formation and Diabetic Glomerular Microvascular Injuries. J Diabetes Res. 2017;2017:9603924. 
  3. Luque Y, Lenoir O, Bonnin P, Hardy L, Chipont A, Placier S, Vandermeersch S, Xu-Dubois YC, Robin B, Lazareth H, Souyri M, Guyonnet L, Baudrie V, Camerer E, Rondeau E, Mesnard L, Tharaux PL. Endothelial Epas1 Deficiency Is Sufficient To Promote Parietal Epithelial Cell Activation and FSGS in Experimental Hypertension. J Am Soc Nephrol. 2017 Dec;28(12):3563-3578. 
  4. Henique C, Bollée G, Loyer X, Grahammer F, Dhaun N, Camus M, Vernerey J, Guyonnet L, Gaillard F, Lazareth H, Meyer C, Bensaada I, Legrès L, Satoh T, Akira S, Bruneval P, Dimmeler S, Tedgui A, Karras A, Thervet E, Nochy D, Huber TB, Mesnard L, Lenoir O, Tharaux PL. Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis. Nat Commun. 2017 Nov 28;8(1):1829 
  5. Koehl B, Nivoit P, El Nemer W, Lenoir O, Hermand P, Pereira C, Brousse V, Guyonnet L, Ghinatti G, Benkerrou M, Colin Y, Le Van Kim C, Tharaux PL. The endothelin B receptor plays a crucial role in the adhesion of neutrophils to the endothelium in sickle cell disease. Haematologica. 2017 Jul;102(7):1161-1172 
  6. Garsen M, Lenoir O, Rops AL, Dijkman HB, Willemsen B, van Kuppevelt TH, Rabelink TJ, Berden JH, Tharaux PL, van der Vlag J. Endothelin-1 Induces Proteinuria by Heparanase-Mediated Disruption of the Glomerular Glycocalyx. J Am Soc Nephrol. 2016 Dec;27(12):3545-3551 
  7. Lenoir O, Jasiek M, Henique C, Guyonnet L, Hartleben B, Bork T, Chipont A, Flosseau K, Bensaada I, Schmitt A, Massé JM, Souyri M, Huber TB, Tharaux PL. Endothelial cell- and Podocyte Autophagy Synergistically protect from Diabetes-induced Glomerulosclerosis. Autophagy. 2015;11(7):1130-45. 
  8. Henique C, Bollee G, Lenoir O, Dhaun N, Camus M, Chipont A, Flosseau K, Mandet C, Yamamoto M, Karras A, , Thervet E, Bruneval P, Nochy D, Mesnard L, Tharaux PL. NRF2 Drives Podocyte-Specific PPARg Expression that Is Essential to Promotes Resistance to Crescentic Glomerulonephritis. Proof of Principle for Potential Therapy. J Am Soc Nephrol. 2016 Jan;27(1):172-88. 
  9. Henique C, Papista C, Guyonnet L, Lenoir O, Tharaux PL. Update on crescentic glomerulonephritis. Semin Immunopathol. 2014 Jul;36(4):479-90. 
  10. Lenoir O, Milon M, Virsolvy A, Henique C, Schmitt A, Masse JM, Kotelevtsev Y, YanagisawaM, Webb DJ, Richard S and Tharaux PL. Direct action of endothelin-1 on podocytes promotes diabetic glomerulosclerosis. J Am Soc Nephrol, 2014, May;25(5):1050-62. 
  11. Lenoir O, Flosseau K, Ma FX, Blondeau B, Mai A, Bassel-Duby R, Ravassard P, Olson EN, Haumaitre C, Scharfmann R. Specific control of pancreatic endocrine β- and δ-cell mass by class IIa histone deacetylases HDAC4, HDAC5, and HDAC9. Diabetes. 2011 Nov;60(11):2861-71. 
  12. Haumaitre C, Lenoir O, Scharfmann R. Histone deacetylase inhibitors modify pancreatic cell fate determination and amplify endocrine progenitors. Mol Cell Biol. 2008 Oct;28(20):6373-83.
1 Protocol published
Immunofluorescence Staining of WT-1/Podocalyxin on Mouse Kidney Sections
Authors:  Carole Henique, Olivia Lenoir and Pierre-Louis Tharaux, date: 04/20/2019, view: 938, Q&A: 0
In glomerular diseases, podocytes are one type of cells involved in dysfunction of glomerular filtration. In these conditions, podocyte proteins expression change. Therefore, immunofluorescent staining of podocytes can be performed to visualize ...
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