Pierre-Louis Tharaux Institut National de la Santé et de la Recherche Médicale
1 protocol

Carole Henique Institut Mondor de Recherche Biomédicale , Inserm U955/University Paris Est Créteil, France
1 protocol

Olivia Lenoir
  • Research scientist, INSERM
Research focus
  • Cell biology
  • Nephrology, Podocytes, diabetes, hypertension
  • 1 Author merit


PhD, University Paris Diderot, 2011

Lab information

Inserm U970-PARCC


- Podocytes Maintain High Basal Levels of Autophagy Independent of Mtor Signaling. Tillmann Bork, Wei Liang , Kosuke Yamahara , Philipp Lee , Zhejia Tian, Shuya Liu, Christoph Schell , Kathrin Thedieck, Bjoern Hartleben, Ketan Patel , Pierre-Louis Tharaux , Olivia Lenoir , Tobias B Huber. Autophagy 23 Dec 2019
- The Tetraspanin CD9 Controls Migration and Proliferation of Parietal Epithelial Cells and Glomerular Disease Progression. Hélène Lazareth, Carole Henique , Olivia Lenoir , Victor G Puelles, Martin Flamant, Guillaume Bollée, Cécile Fligny, Marine Camus, Lea Guyonnet, Corinne Millien , François Gaillard, Anna Chipont, Blaise Robin, Sylvie Fabrega, Neeraj Dhaun, Eric Camerer, Oliver Kretz, Florian Grahammer , Fabian Braun, Tobias B Huber, Dominique Nochy, Chantal Mandet, Patrick Bruneval, Laurent Mesnard , Eric Thervet, Alexandre Karras, François Le Naour, Eric Rubinstein, Claude Boucheix, Antigoni Alexandrou , Marcus J Moeller, Cédric Bouzigues, Pierre-Louis Tharaux.
- A novel role for myeloid endothelin-B receptors in hypertension. Czopek A, Moorhouse R, Guyonnet L, Farrah T, Lenoir O, Owen E, van Bragt J, Costello HM, Menolascina F, Baudrie V, Webb DJ, Kluth DC, Bailey MA, Tharaux PL, Dhaun N. Eur Heart J. 2019 Jan 17
- Hmox1 Deficiency Sensitizes Mice to Peroxynitrite Formation and Diabetic Glomerular Microvascular Injuries. Lenoir O, Gaillard F, Lazareth H, Robin B, Tharaux PL. J Diabetes Res. 2017
- Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis. Henique C, Bollée G, Loyer X, Grahammer F, Dhaun N, Camus M, Vernerey J, Guyonnet L, Gaillard F, Lazareth H, Meyer C, Bensaada I, Legrès L, Satoh T, Akira S, Bruneval P, Dimmeler S, Tedgui A, Karras A, Thervet E, Nochy D, Huber TB, Mesnard L, Lenoir O, Tharaux PL. Nat Commun. 2017 Nov 28;8(1):1829.
- Endothelial Epas1 deficiency is sufficient to promote parietal epithelial cell activation and FSGS in experimental hypertension. Luque Y*, Lenoir O*, Bonnin P, Hardy L, Chipont A, Placier S, Vandermeersch S, Xu-Dubois YC, Robin B, Lazareth H, Souyri M, Guyonnet L, Baudrie V, Camerer E, Rondeau E, Mesnard L, Tharaux PL. * même contribution. J Am Soc Nephrol. 2017 Dec;28(12):3563-3578
- The endothelin B receptor plays a crucial role for the adhesion of neutrophils to the endothelium in sickle cell disease. Koehl B*, Nivoit P*, El Nemer W*, Lenoir O*, Hermand P, Pereira C, Brousse V, Guyonnet L, Ghinatti G, Benkerrou M, Colin Y, Le Van Kim C, Tharaux PL. * même contribution. Haematologica. 2017 Apr 6
- Autophagy in kidney disease and aging: lessons from rodent models. Lenoir O, Tharaux PL, Huber TB. Kidney Int. 2016 Nov;90(5):950-964.
- Endothelin-1 Induces Proteinuria by Heparanase-Mediated Disruption of the Glomerular Glycocalyx. Garsen M, Lenoir O, Rops AL, Dijkman HB, Willemsen B, van Kuppevelt TH, Rabelink TJ, Berden JH, Tharaux PL, van der Vlag J. J Am Soc Nephrol. 2016 Dec;27(12):3545-3551
- Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis. Lenoir O, Jasiek M, Hénique C, Guyonnet L, Hartleben B, Bork T, Chipont A, Flosseau K, Bensaada I, Schmitt A, Massé JM, Souyri M, Huber TB, Tharaux PL. Autophagy. 2015;11(7):1130-45.
- Nuclear Factor Erythroid 2-Related Factor 2 Drives Podocyte-Specific Expression of Peroxisome Proliferator-Activated Receptor γ Essential for Resistance to Crescentic GN. Henique C, Bollee G, Lenoir O, Dhaun N, Camus M, Chipont A, Flosseau K, Mandet C, Yamamoto M, Karras A, Thervet E, Bruneval P, Nochy D, Mesnard L, Tharaux PL. J Am Soc Nephrol. 2016 Jan;27(1):172-88.
- Update on crescentic glomerulonephritis. Hénique C, Papista C, Guyonnet L, Lenoir O, Tharaux PL. Semin Immunopathol. 2014 Jul;36(4):479-90.
- Direct action of endothelin-1 on podocytes promotes diabetic glomerulosclerosis. Lenoir O, Milon M, Virsolvy A, Hénique C, Schmitt A, Massé JM, Kotelevtsev Y, Yanagisawa M, Webb DJ, Richard S, Tharaux PL. J Am Soc Nephrol. 2014 May;25(5):1050-62.
- Specific control of pancreatic endocrine β- and δ-cell mass by class IIa histone deacetylases HDAC4, HDAC5, and HDAC9. Lenoir O, Flosseau K, Ma FX, Blondeau B, Mai A, Bassel-Duby R, Ravassard P, Olson EN, Haumaitre C, Scharfmann R. Diabetes. 2011 Nov;60(11):2861-71
- Directing cell differentiation with small-molecule histone deacetylase inhibitors: the example of promoting pancreatic endocrine cells. Haumaitre C, Lenoir O, Scharfmann R. Cell Cycle. 2009 Feb 15;8(4):536-44.
- Histone deacetylase inhibitors modify pancreatic cell fate determination and amplify endocrine progenitors. Haumaitre C, Lenoir O, Scharfmann R. Mol Cell Biol. 2008 Oct;28(20):6373-83.
1 Protocol published
Authors:  Carole Henique, Olivia Lenoir and Pierre-Louis Tharaux, date: 04/20/2019, view: 3913, Q&A: 0
In glomerular diseases, podocytes are one type of cells involved in dysfunction of glomerular filtration. In these conditions, podocyte proteins expression change. Therefore, immunofluorescent staining of podocytes can be performed to visualize ...
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