hiroshi3@stanford.edu de Lecea
  • Research scientist, Stanford University
Research focus
  • Neuroscience
  • 1 Author merit


Ph.D., University of Barcelona, US, 1991


• Yamaguchi, H. and de Lecea, L. (2019). In vivo cell type-specific CRISPR gene editing for sleep research. J Neurosci Methods 316: 99-102.
• Eban-Rothschild, A., Appelbaum, L. and de Lecea, L. (2018). Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive. Neuropsychopharmacology 43(5): 937-952.
• Giardino, W. J., Eban-Rothschild, A., Christoffel, D. J., Li, S. B., Malenka, R. C. and de Lecea, L. (2018). Parallel circuits from the bed nuclei of stria terminalis to the lateral hypothalamus drive opposing emotional states. Nat Neurosci 21(8): 1084-1095.
• Li, S. B., Nevarez, N., Giardino, W. J. and de Lecea, L. (2018). Optical probing of orexin/hypocretin receptor antagonists. Sleep 41(10).
• Nevarez, N. and de Lecea, L. (2018). Recent advances in understanding the roles of hypocretin/orexin in arousal, affect, and motivation. F1000Res 7.
• Steiner, N., Rossetti, C., Sakurai, T., Yanagisawa, M., de Lecea, L., Magistretti, P. J., Halfon, O. and Boutrel, B. (2018). Hypocretin/orexin deficiency decreases cocaine abuse liability. Neuropharmacology 133: 395-403.
• Yamaguchi, H., Hopf, F. W., Li, S. B. and de Lecea, L. (2018). In vivo cell type-specific CRISPR knockdown of dopamine beta hydroxylase reduces locus coeruleus evoked wakefulness. Nat Commun 9(1): 5211.
1 Protocol published
Construction of Viral Vectors for Cell Type-specific CRISPR Gene Editing in the Adult Mouse Brain
Authors:  Hiroshi Yamaguchi and Luis de Lecea, date: 08/20/2019, view: 425, Q&A: 0
Recently developed gene editing technologies based on engineered CRISPR/Cas9 systems enables researchers to disrupt genes in a cell type-specific manner in the adult mouse brain. Using these technologies, we recently showed that the dopamine ...
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