hiroshi3@stanford.edu de Lecea
  • Research scientist, Stanford University
Research focus
  • Neuroscience
  • 1 Author merit

Education

Ph.D., University of Barcelona, US, 1991

Publications

https://scholar.google.com/citations?user=diTSv4YAAAAJ&hl=en
• Yamaguchi, H. and de Lecea, L. (2019). In vivo cell type-specific CRISPR gene editing for sleep research. J Neurosci Methods 316: 99-102.
• Eban-Rothschild, A., Appelbaum, L. and de Lecea, L. (2018). Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive. Neuropsychopharmacology 43(5): 937-952.
• Giardino, W. J., Eban-Rothschild, A., Christoffel, D. J., Li, S. B., Malenka, R. C. and de Lecea, L. (2018). Parallel circuits from the bed nuclei of stria terminalis to the lateral hypothalamus drive opposing emotional states. Nat Neurosci 21(8): 1084-1095.
• Li, S. B., Nevarez, N., Giardino, W. J. and de Lecea, L. (2018). Optical probing of orexin/hypocretin receptor antagonists. Sleep 41(10).
• Nevarez, N. and de Lecea, L. (2018). Recent advances in understanding the roles of hypocretin/orexin in arousal, affect, and motivation. F1000Res 7.
• Steiner, N., Rossetti, C., Sakurai, T., Yanagisawa, M., de Lecea, L., Magistretti, P. J., Halfon, O. and Boutrel, B. (2018). Hypocretin/orexin deficiency decreases cocaine abuse liability. Neuropharmacology 133: 395-403.
• Yamaguchi, H., Hopf, F. W., Li, S. B. and de Lecea, L. (2018). In vivo cell type-specific CRISPR knockdown of dopamine beta hydroxylase reduces locus coeruleus evoked wakefulness. Nat Commun 9(1): 5211.
1 Protocol published
Construction of Viral Vectors for Cell Type-specific CRISPR Gene Editing in the Adult Mouse Brain
Authors:  Hiroshi Yamaguchi and Luis de Lecea, date: 08/20/2019, view: 425, Q&A: 0
Recently developed gene editing technologies based on engineered CRISPR/Cas9 systems enables researchers to disrupt genes in a cell type-specific manner in the adult mouse brain. Using these technologies, we recently showed that the dopamine ...
We use cookies on this site to enhance your user experience. By using our website, you are agreeing to allow the storage of cookies on your computer.