Peng Li 1 protocol

Boon Tin Chua Institute of Metabolism and Integrated Biology, Fudan University
1 protocol

Jia Wang School of Pharmaceutical Science, Tsinghua University
1 protocol

Feng-Jung Chen
  • Faculty, Fudan University
Research focus
  • Cell biology
  • Modeling in Biophysics & Lipid Metabolism
  • 1 Author merit

Education

Doctor of Philosophy, National Chiao Tung University, 2012

Publications

1. Peer-reviewed Journal Papers
• Lu Su†, Linkang Zhou†, Feng-Jung Chen, Huimin Wang, Hui Qian, Yuanyuan Sheng, Yuangang Zhu, Hua Yu, Xinqi Gong, Li’e Cai, Xuerui Yang, Li Xu, Tong-Jin Zhao, John Zhong Li, Xiao-Wei Chen*, and Peng Li*. Cideb controls sterol-regulated ER export of SREBP/SCAP by promoting cargo loading at ER exit sites. EMBO J. e100156 (March 2019). (IF: 10.557) (†Co-first authors)
• Jia Wang, Chengsong Yan, Chenqi Xu, Boon Tin Chua, Peng Li*, and Feng-Jung Chen*. Polybasic RKKR motif in the linker region of lipid droplet (LD)-associated protein CIDEC inhibits LD fusion activity by interacting with acidic phospholipids. J. Biol. Chem. 293:19330–19343 (December 2018). (SCI IF: 4.573) (*Corresponding authors)
• Guangang Gao, Feng-Jung Chen, Linkang Zhou, Lu Su, Dijin Xu, Li Xu*, and Peng Li*. Control of Lipid Droplet Fusion and Growth by CIDE Family Proteins. BBA Mol. Cell Biol. Lipids. 1862:1197–1204 (June 2017). (IF: 5.547) (Review article) (*Corresponding authors)
• Hui Qian†, Yuanying Chen†, Zongqian Nian, Lu Su, Haoyong Yu, Feng-Jung Chen, Xiuqin Zhang, Wenyi Xu, Linkang Zhou, Jiaming Liu, Jinhai Yu, Luxin Yu, Yan Gao, Hongchao Zhang, Haihong Zhang, Shimin Zhao, Li Yu, Rui-Ping Xiao, Yuqian Bao, Shaocong Hou, Pingping Li, Jiada Li, Haiteng Deng, Weiping Jia, and Peng Li. HDAC6-Mediated Acetylation of Lipid Droplet–Binding Protein CIDEC Regulates Fat-Induced Lipid Storage. J. Clin. Invest. 127(4):1353–1369 (March 2017). (SCI IF: 12.575) (†Co-first authors)
• Shu-Yun Tung, Sue-Hong Wang, Sue-Ping Lee, Shu-Ping Tsai, Hsiao-Hsuian Shen, Feng-Jung Chen, Yu-Yi Wu, Sheng-Pin Hsiao, and Gunn-Guang Liou. Modulations of SIR-Nucleosome Interactions of Reconstructed Yeast Silent Pre-Heterochromatin by O-acetyl-ADP-Ribose and Magnesium. Mol. Biol. Cell. 28(3):381–386 (December 2016). (SCI IF: 4.037)
• Wenyi Xu, Lizhen Wu, Miao Yu, Feng-Jung Chen, Muhammad Arshad, Xiayu Xia, Hao Ren, Jinhai Yu, Li Xu, Dijin Xu, John Zhong Li, Peng Li*, and Linkang Zhou*. Differential Roles of CIDE Proteins in Promoting Lipid Droplet Fusion and Growth in Subpopulations of Hepatocytes. J. Biol. Chem. 291(9):4282–4293 (January 2016). (SCI IF: 4.573) (*Corresponding authors)
• Feng-Jung Chen†, Kuan-Wei Lee†, Chun-Chieh Lai†, Sue-Ping Lee, Hsiao-Hsuian Shen, Shu-Ping Tsai, Bang-Hung Liu, Ling-Mei Wang, and Gunn-Guang Liou. Structure of Native Oligomeric Sprouty2 by Electron Microscopy and Its Property of Electroconductivity. Biochem. Biophys. Res. Commun. 439(3):351–356 (September 2013). (SCI IF: 2.281) (†Co-first authors)
• Feng-Jung Chen, Jhih-Sian Wong, Ken Y. Hsu, and Long Hsu. Thermally Activated State Transition Technique for Femto-Newton-Level Force Measurement. Opt. Lett. 37(9):1469–1471 (May 2012). (SCI IF: 3.385)
• Chia-Han Chan†, Feng-Jung Chen†, Ying-Jung Huang, Hsin-Yu Chen, Kuo-Liang Liu, Zhe-Chong Wang, Hwei-Ling Peng, Tri-Rung Yew, Cheng-Hsien Liu, Gunn-Guang Liou, Ken Y. Hsu, Hwan-You Chang, and Long Hsu. Identification of Protein Domains Affecting Mechanical Properties of Klebsiella pneumoniae Type 3 Fimbriae. Langmuir. 28(19):7428–7435 (April 2012). (SCI IF: 4.187) (†Co-first authors)
• Feng-Jung Chen†, Chia-Han Chan†, Ying-Jung Huang, Kuo-Liang Liu, Hwei-Ling Peng, Hwan-You Chang, Gunn-Guang Liou, Tri-Rung Yew, Cheng-Hsien Liu, Ken Y. Hsu, and Long Hsu. Structural and Mechanical Properties of Klebsiella pneumonia Type 3 Fimbriae. J. Bacteriol. 193(7):1718–1725 (April 2011). (SCI Impact factor (IF): 3.825) (†Co-first authors)

2. International Conference Presentations
• Feng-Jung Chen, Xuchao Lv, Shuangru Huang, Jia Wang, Chao Huang, Boxin Xue, Thorsten Wohland, Yujie Sun, and Peng Li. Biophysical Modelling and Techniques for Lipid Droplet Biology. Poster Presented at Cold Spring Harbor Asia Meeting on Lipid Metabolism and Human Metabolic Disorders, Suzhou, China, 1–5 June 2015. (Cold Spring Harbor Asia Fellowship Award)
• Feng-Jung Chen, Ken Y. Hsu, Long Hsu, and Gunn-Guang Liou. Structural characterization of Klebsiella pneumoniae type 3 fimbriae under electron microscopy. Oral Presented at the 10th Asia-Pacific Microscopy Conference (APMC 10), on Cell and Tissues Structures section, Perth, Western Australia, Australia, 5–9 February 2012.
• Feng-Jung Chen, Ken Y. Hsu, and Long Hsu. Force-Driven Changes in Transition Rates of a Particle in Dual Optical Traps. Poster Presented at the 7th Joint Meeting of Chinese Physicists Worldwide International Conference (OCPA7) on Statistical & Nonlinear section, Kaohsiung, Taiwan, Republic of China, 1–5 August 2011.
• Feng-Jung Chen, Ken Y. Hsu, and Long Hsu. Biomechanical Properties of Klebsiella pneumonia Type 3 Fimbriae. Oral Presented at the 6th Joint Meeting of Chinese Physicists Worldwide International Conference (OCPA6) on Biophysics section, Lanzhou, China, 3–7 August 2009.
• Feng-Jung Chen, Chia-Han Chan, Kuo-Liang Liu, Ying-Jung Huang, Hwei-Ling Peng, Hwan-You Chang, Tri-Rung Yew, Ken Y. Hsu, and Long Hsu. Uncoiling Mechanism of Klebsiella pneumoniae Type 3 Pili Measured by using Optical Tweezers. Oral Presented at the Conference on Optical Trapping and Optical Micromanipulation IV, San Diego, CA, 26–29 August 2007. Proc. SPIE 6644, 66441W. doi:10.1117/12.733097. (EI)

3. Domestic Conference Presentations
• Feng-Jung Chen, Xuchao Lv, Yun Zhu, Shuangru Huang, Jia Wang, Thorsten Wohland, Yujie Sun, and Peng Li. Cidec Proteins-enriched Cake Crucially Determines Lipid Droplet Fusion in Cell. Poster Presented at the 2016 International Conference on Lipid Metabolism and Bioenergetics, Dalian Medical University, Dalian, 1–3 July 2016. (Excellent Poster Award in 2016 LBSC Conference)
• Hsuan-Hao Chao, Feng-Jung Chen, Ken Y.Hsu, and Long Hsu. Direct Measurement of Ultra-Weak Forces by Using a Modified State Transition Technique. Poster Presented at the Annual Meeting of the Physical Society of ROC on Optics and Electro-optics section, National Chung Cheng University, Chiayi County, 17–19 January 2012.
• Feng-Jung Chen, Jhih-Sian Wong, Ken Y.Hsu, and Long Hsu. State Transition Technique for Ultra-Weak Force Measurement Beyond the Thermal Noise Limit. Oral Presented at the Annual Meeting of the Physical Society of ROC on Optics and Electro-optics section, National Chung Cheng University, Chiayi County, 17–19 January 2012.
• Jhih-Sian Wong, Feng-Jung Chen, Gan-Guang Liou, Ken Y.Hsu, and Long Hsu. Characterization of Structure and Young's Modulus of Klebsiella pneumoniae Type 3 Fimbriae by Transmission Electron Microscopy. Poster Presented at the Annual Meeting of the Physical Society of ROC on Bio-physics and Soft Matter section, National Cheng Kung University, Tainan city, 2–4 February 2010. (Superior Poster Award)
• Feng-Jung Chen, Chia-Han Chan, Ying-Jung Huang, Hwei-Ling Peng, Hwan-You Chang, Tri-Rung Yew, Cheng-Hsien Liu, and Long Hsu. The Stretched Behavior of Klebsiella pneumoniae Type 3 Fimbriae Studied by Optical Tweezers. Oral Presented at the Annual Meeting of the Physical Society of ROC on Bio-physics and Soft Matter section, National Cheng Kung University, Tainan city, 2–4 February 2010.
• Feng-Jung Chen et al. Physical Properties of Klebsiella pneumoniae Type 3 Fimbriae Measured by Optical Tweezers. Oral Presented at Annual Meeting of Bacterial Society of ROC, Hsinchu, 22 August 2007 . (Invited Talk)
1 Protocol published
Lipid-exchange Rate Assay for Lipid Droplet Fusion in Live Cells
Authors:  Jia Wang, Boon Tin Chua, Peng Li and Feng-Jung Chen, date: 07/20/2019, view: 488, Q&A: 0
Lipid droplets (LDs) are central organelles in maintaining lipid homeostasis. Defective LD growth often results in the development of metabolic disorders. LD fusion and growth mediated by cell death–inducing DNA fragmentation factor alpha ...
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