Achira Roy Seattle Children's Research Institute
1 protocol

Giusy Tornillo Cardiff University
21 protocols

Narayan Subramanian Florida State University
9 protocols

Jingwen Yu
  • Clinical Lab Scientist, University of Maryland Medical Center
Research focus
  • Neuroscience

Lab information

Clinical Core Laboratories of Pathology
University of Maryland Medical Center


Jingwen Yu, Feng Zhang, Shuo Wang, Ming Fan, Zhiheng Xu. TAK1 is activated by TGF-β signaling and controls axonal growth during brain development. J Mol Cell Biol. 2014 Aug;6(4):349-51.

Jingwen Yu, Yanqing Wu, Peixin Yang. High glucose-induced oxidative stress represses sirtuin deacetylase expression and increases histone acetylation leading to neural tube defects. J Neurochem. 2016 Feb 20. doi:

Fang Wang*, Hongbo Weng*, Michael J. Quon, Jingwen Yu*, Jian-Ying Wang, Anne-Odile Hueber, Peixin Yang. Dominant negative FADD dissipates the proapoptotic signalosome of the unfolded protein response in diabetic embryopathy. Am J Physiol Endocrinol Metab. 2015 Nov 15; 309(10):E861-73. (Co-first author)

Dan Xu , Minghui Yao , Yaqing Wang , Ling Yuan , Joerg D. Hoeck , Jingwen Yu, Liang Liu, Yvonne Y. C. Yeap, Weiya Zhang, Feng Zhang, Yinghang Feng, Tiantian Ma, Yujie Wang, Dominic C. H. Ng, Xiaoyin Niu, Bing Su, Axel Behrens , Zhiheng Xu. MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis. Plos Biology. 2018 Dec 19;16(12)

Feng Zhang, Jingwen Yu, Tao Yang, Dan Xu, Zhixia Chi, Yanheng Xia, Zhiheng Xu. A Novel c-Jun N-terminal Kinase (JNK) Signaling Complex Involved in Neuronal Migration during Brain Development. J Biol Chem. 2016 Mar 29. pii: jbc.M116.716811.

Fang Wang, Cheng Xu, E. Albert Reece, Xuezheng Li, Yanqing Wu, Christopher Harman, Jingwen Yu, Daoyin Dong, Cheng Wang, Penghua Yang, Jianxiang Zhong & Peixin Yang. Protein kinase C-alpha suppresses
autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy. Nat Commun. 2017 May 5;8:15182.

Hui Gu, Jingwen Yu, Daoyin Dong, Qun Zhou, Jain-Ying Wang, Shengyun Fang, Peixin Yang. High glucose-
repressed CITED2 expression through miR-200b triggers the unfolded protein response and endoplasmic reticulum stress. Diabetes. 2016 Jan;65(1):149-63

Daoyin Dong, Jingwen Yu, Yanqing Wu, Noah Fu, Natalia Arias Villela, Peixin Yang. Maternal diabetes triggers DNA damage and DNA damage response in neurulation stage embryos through oxidative stress. Biochem
Biophys Res Commun. 2015 Nov 13;467(2):407-12.

Hui Gu, Jingwen Yu, Daoyin Dong, Qun Zhou, Jain-Ying Wang, Peixin Yang. The miR-322-TRAF3 circuit mediates the pro-apoptotic effect of high glucose in neural stem cells. Toxicological science. 2015 Mar;144(1):186-96.
2 Protocols reviewed
GeneWeld: Efficient Targeted Integration Directed by Short Homology in Zebrafish

Efficient precision genome engineering requires high frequency and specificity of integration at the genomic target site. Multiple design strategies for zebrafish gene targeting have previously been reported with widely varying frequencies for

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Co-culture of Human Stem Cell Derived Neurons and Oligodendrocyte Progenitor Cells
Authors:  Stephanie Dooves, Aishwarya G. Nadadhur, Lisa Gasparotto and Vivi M. Heine, date: 09/05/2019, view: 4144, Q&A: 0
Crosstalk between neurons and oligodendrocytes is important for proper brain functioning. Multiple co-culture methods have been developed to study oligodendrocyte maturation, myelination or the effect of oligodendrocytes on neurons. However, most of ...
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