Rui Du 1 protocol

Chun-Li Li 1 protocol

Yang Yu 1 protocol

Jun Chen
  • Professor and Director, Institute for Biomedical Sciences of Pain, Tangdu Hospital, The Fourth Military Medical University, China
Research focus
  • Neuroscience
  • 1 Author merit


PhD, MD, Shiga University of Medical Sciences, Japan, 1997


(Since 2014)
· Liu MG, Chen J*. Preclinical research on pain comorbidity with affective disorders and cognitive deficits: challenges and perspectives. Prog Neurobiol 2014, 116:13-32.
· Lu YF, He Y, Wang Y, Zhang FK, He T, Wang RR, Chen XF, Yang F, Gong KR, Chen J*. Spatial and temporal plasticity of synaptic organization in anterior cingulate cortex following peripheral inflammatory pain: multi-electrode array recordings in rats. Neurosci Bull, 2014, 30:1-20.
· Wang RR, Jin JH, Womack AW, Lyu D, Kokake SS, Tang N, Zou X, Lin Q, Chen J*. Neonatal ketamine exposure causes impairment of long-term synaptic plasticity in the anterior cingulate cortex of rats. Neuroscience 2014, 268:309–317.
· Xie F, Liang P, Fu H, Zhang JC, Chen J. Effects of normal aging on myelin sheath ultrastructures in rat somatic sensorimotor system. Molecular Medicine Report 2014, 10:459-466.
· Xie F, Fu H, Zhang JC, Chen XF, Wang XL, Chen J. Gene profiling in dynamic regulation of lifespan myelin sheath structure in rats’ optic nerve. Molecular Medicine Report 2014, 10:217-222.
· Li Z, Lu YF, Li CL, Wang Y, Sun W, He T, Chen XF, Wang XL, Chen J*. Social interaction with a cagemate in pain facilitates subsequent spinal nociception via activation of the medial prefrontal cortex in rats. Pain 2014, 155: 1253-1261. (With special commentary, see Longford and Williams. Pain 2014)
· Yang F, Fu H, Lu YF, Wang XL, Yang Y, Yang F, Yu YQ, Sun W, Wang JS, Costigan M, Chen J*. Post-stroke pain hypersensitivity induced by experimental thalamic hemorrhage in rats is region-specific and demonstrates limited efficacy of gabapentin. Neurosci Bull 2014, 30:887-902.
· Yu YQ, Chen XF, Yang Y, Yang F, Chen J*. Electrophysiological identification of tonic and phasic neurons in sensory dorsal root ganglion and their distinct implications in inflammatory pain. Physiological Research 2014, 63:793-799.
· Yang F, Sun W, Yang Y, Wang Y, Li C-L, Fu H, Wang X-L, Yang F, He T, Chen J*. SDF1-CXCR4 signaling contributes to persistent pain and hypersensitivity via regulating excitability of primary nociceptive neurons: involvement of ERK-dependent Nav1.8 up-regulation. J Neuroinflam 2015,12:219.
· Yang Y, Yang F, Yang F, Li C-L, Wang Y, Li Z, Lu Y-F, Yu Y-Q, Fu H, He T, Sun W, Wang R-R, Chen J*. Gabapentinoid insensitivity after repeated administration is associated with down-regulation of 2-1 subunit in rats with central post-stroke pain hypersensitivity. Neurosci Bull 2016, 32:41-50.
· Wang Y, Lu Y-F, Li C-L, Sun W, Li Z, Wang R-R, He T, Yang F, Yang Y, Wang X-L, Guan S-M, Chen J*. Involvement of Rac1 signaling pathway in the development and maintenance of acute inflammatory pain induced by bee venom injection. Br J Pharmacol 2016, 173:937–950.
· Lu YF, Neugebauer V, Chen J, Li Z. Distinct contributions of reactive oxygen species in amygdala to bee venom-induced spontaneous pain-related behaviors. Neurosci Lett 2016, 619:68-72. doi: 10.1016/j.neulet.2016.03.015
· Chen J*, Guan SM, Sun W, Fu H. Melittin: the major pain-producing substance of bee venom. Neurosci Bull 2016, 32: 265-272. DOI 10.1007/s12264-016-0024-y
· Geng KW, He T, Wang RR, Li CL, Luo WJ, Wu FF, Wang Y, Li Z, Lu YF, Guan SM, Chen J*. Ethanol Increases Mechanical Pain Sensitivity in Rats via Activation of GABAA Receptors in Medial Prefrontal Cortex. Neurosci Bull 2016, 32:433-44. doi: 10.1007/s12264-016-0063-4.
· Sun W, Yang F, Wang Y, Fu H, Yang Y, Li CL, Wang XL, Lin Q, Chen J*. Contribution of large-sized primary sensory neuronal sensitization to mechanical allodynia by upregulation of hyperpolarization-activated cyclic nucleotide gated channels via cyclooxygenase 1 cascade. Neuropharmacology 2017, 113:217-230. doi: 10.1016/j.neuropharm.2016.10.012.
· Yang F, Sun W, Luo WJ, Yang Y, Yang F, Wang XL, Chen J*. SDF1-CXCR4 Signaling Contributes to the Transition from Acute to Chronic Pain State. Mol Neurobiol 2017, 54:2763-2775. doi: 10.1007/s12035-016-9875-5.
· Peng WW, Guo XL, Jin QQ, Wei H, Xia XL, Zhang Y, Huang PC, Wang WC, Li SL, Wang JS, Chen J*, Hu L*. Biological mechanism of post-herpetic neuralgia: Evidence from multiple patho-psychophysiological measures. Eur J Pain. 2017, 21:827-842. doi: 10.1002/ejp.985.
· Wang JL, Zhang WJ, Gao M, Zhang S, Tian DH, Chen J*. A cross-cultural adaptation and validation of the short-form McGill Pain Questionnaire-2: Chinese version in patients with chronic visceral pain. J Pain Res 2017, 10:121-128. doi: 10.2147/JPR.S116997.
· Yu F, Zhao ZY, He T, Yu YQ, Li Z, Chen J*. Temporal and spatial dynamics of peripheral afferent-evoked activity in the dorsal horn recorded in rat spinal cord slices. Brain Res Bull 2017, 131:183-191. doi: 10.1016/j.brainresbull.2017.04.012.
· Luo WJ, Yang F, Yang F, Sun W, Zheng W, Wang XL, Wu FF, Wang JL, Wang JS, Guan SM, Chen J*. Intervertebral foramen injection of ozone relieves mechanical allodynia and enhances analgesic effect of gabapentin in animal model of neuropathic pain. Pain Physician 2017, 20:E673-E685. PubMed PMID: 28727712.
· Yang F, Luo WJ, Sun W, Wang Y, Wang JL, Yang F, Li CL, Wei N, Wang XL, Guan SM, Chen J*. SDF1-CXCR4 Signaling maintains central post-stroke pain through mediation of glial-neuronal interactions. Front Mol Neurosci 2017, 10:226. doi: 10.3389/fnmol.2017.00226.
· Lü YF, Yang Y, Li C-L, Wang Y, Li Z, Chen J*. The locus coeruleus–norepinephrine system mediates empathy for pain through selective up-regulation of P2X3 receptor in dorsal root ganglia in rats. Front Neural Circuits 2017, 11:66. doi: 10.3389/fncir.2017.00066
· Chen J*. Empathy for distress in humans and rodents. Neurosci Bull 2018, 34:216–236. doi: 10.1007/s12264-017-0135-0.
· Wang RR, Wang Y, Guan SM, Li Z, Kokane S, Cao FL, Sun W, Li CL, He T, Yang Y, Lin Q*, Chen J*. Synaptic homeostasis and allostasis in the dentate gyrus caused by inflammatory and neuropathic pain conditions. Front Synaptic Neurosci 2018, 10:1. doi: 10.3389/fnsyn.2018.00001
· Li CL, Yu Y, He T, Wang RR, Geng KW, Du R, Luo WJ, Wei N, Wang XL, Wang Y, Yang Y, Yu YQ, Chen J*. Validating rat model of empathy for pain: effects of pain expressions in social partners. Front Behav Neurosci 2018, 12:242. doi:10.3389/fnbeh.2018.00242.
· Cao FL, Xu M, Gong KR, Wang Y, Wang RR, Chen XF, Chen J.* Imbalance between excitatory and inhibitory synaptic transmission in the primary somatosensory cortex caused by persistent nociception in rats. J Pain, 2019
· Chen J, Han JS, Zhao ZQ, Wei F, Hsieh JC, Bao L, Chen ACN, Dai Y, Fan BF, Gu JG., Hao SL, Hu SJ, Ji YH, Li YJ, Li YQ, Lin Q, Liu XG, Liu YQ, Lu Y, Luo F, Ma C, Qui YH, Rao ZR, Shi L, Shyu BC, Song XJ, Tang JS, Tao YX, Wan Y, Wang JS, Wang KW, Wang Y, Xu GY, Xu TL, You HJ, Yu LC, Yu SY, Zhang DY, Zhang DR, Zhang JM, Zhang X, Zhang YQ, Zhuo M. Pain, In: Pfaff DW (Ed.), Neuroscience in the 21st Century: From Basic to Clinical. New York: Springer, 2013, pp. 965–1023. DOI 10.1007/978-1-4614-1997-6
· Chen J and Guan SM. Bee venom and Pain. In: Gopalakrishnakone P. (Editor), Toxinology: Toxins and Drug Discovery. Springer,2017, pp 253-294. DOI 10.1007/978-94-007-6726-3_1-1
· Chen J and Guan SM. Myelinodegeneration and its influence on pain: Aging, diet and genetic dysregulation. In: Watson R.R. and Zibadi S. (Eds), Nutritional modulation of pain. Elsevier, 2017, pp 47-64. doi.10.1016/B978-0-12-805186-3.00004-7
1 Protocol published
Authors:  Yang Yu, Chun-Li Li, Rui Du and Jun Chen, date: 06/20/2019, view: 3468, Q&A: 0
Empathy for pain is referred to as an evolutionary behavior of social animals and humans associated with the ability to feel, recognize, understand and share the other's distressing (pain, social rejection and catastrophe) states. Impairment of ...
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