José Lemos Department of Oral Biology, University of Florida College of Dentistry, USA, USA,
3 protocols

Cristina Colomer-Winter Boehringer Ingelheim
1 protocol

Ana L. Flores-Mireles
  • Faculty, Department of Biological Sciences, University of Notre Dame, USA, USA,
Research focus
  • Microbiology
  • Catheter-associated infections
  • 1 Author merit


PhD, Cornell University, 2012

Lab information

Ana Flores-Mireles lab


  1. Westfall, C., Flores-Mireles, A. L*., Robinson, J.I., Lynch, A. J. L., Hultgren, S., Henderson, J.P., Levin. P. A. 2019. Antimicrobial Agents and Chemotherapy. 63(5). * First Co-author C. W. and A. L. F-M. equal contribution.

  2. Colomer-Winter C, Flores-Mireles AL Baker SP, Frank KL, Lynch AJL, Hultgren SJ, Kitten T and Lemos JA. 2018. Manganese acquisition is essential for virulence of Enterococcus faecalis. PLOS Pathogens. 14(9).

  3. Shen J, Walsh BJC, Flores-Mireles AL, Peng H, Zhang Y, Zhang Y, Trinidad JC, Hultgren SJ, Giedroc DP. 2018. Hydrogen Sulfide Sensing through Reactive Sulfur Species (RSS) and Nitroxyl (HNO) in Enterococcus faecalis. ACS Chem Biol. 2018 Jun 15;13(6):1610-1620. doi: 10.1021/acschembio.8b00230.

  4. Xu, W, Flores-Mireles AL, Cusumano ZT, Takagi E, Hultgren SJ, Caparon MG. 2017. Host and bacterial proteases influence biofilm formation and virulence in a murine model of enterococcal catheter-associated urinary tract infection. NPJ Biofilms and Microbiome. 2017 Nov 6;3:28. doi: 10.1038/s41522-017-0036-z.

  5. Walker JN, Flores-Mireles AL, Pinkner, CL, Schreiber HLt, Joens MS, Park AM, Potretzke AM, Bauman TM, Pinkner JS, Fitzpatrick JAJ, Desai A, Caparon MG, Hultgren SJ. 2017. Catheterization alters the bladder ecology to potentiate Staphylococcus aureus infection of the urinary tract. PNAS. Published ahead of print September 25, 2017, doi:10.1073/pnas.1707572114 (Cover article in Outlook magazine, autumn 2017; UroToday wrote a commentary on this work, Feb 2018 issue)

  6. Ruiz-Rodríguez MA, Vedani A, Flores-Mireles AL, Chairez-Ramirez MH, Gallegos-Infante JA, Gonzalez-Laredo RF. 2017. In silico prediction of the toxic potential of lupeol. Chem Res Toxicol. doi: 10.1021/acs.chemrestox.7b00070.

  7. Flores-Mireles A. L., Walker JN, Potretzke AM, Schreiber HLt, Pinkner JS, Bauman TM, Park AM, Desai A, Hultgren SJ, Caparon MG. 2016. Antibody-based therapy for enterococcal catheter-associated urinary tract infections. MBio. 7(5).

  8. Flores-Mireles A. L., Walker JN, Bauman TM, Potretzke AM, Schreiber HLt, Park AM, Pinkner JS, Caparon MG, Hultgren SJ, Desai A. 2016. Fibrinogen Release and Deposition on Urinary Catheters Placed during Urological Procedures. J Urol 196:416-421.(Highlighted in UroToday)

  9. Conover, M. S., Flores-Mireles, A. L., Hibbing, M. E. Dodson K, Hultgren SJ. 2015.Establishment and Characterization of UTI and CAUTI in a Mouse Model. J Vis Exp: e52892.

  10. Flores-Mireles A. L., Walker JN, Caparon M, Hultgren SJ. 2015. Urinary tract infections: epidemiology, mechanisms of infection and treatment options. Nat Rev Microbiol 13:269-284.

  11. Flores-Mireles, A. L., Pinkner, J. S., Caparon, M. G., and Hultgren, S. J. 2014. An EbpA adhesin vaccine prevents catheter-associated UTI by blocking Enterococcus faecalis biofilms formed by exploitation of fibrinogen. Science Translational Medicine(Nature Reviews Urology wrote a commentary on this work titled “Blocking bacterial biofilms on urinary bladder catheters” and selected as a researcher highlight in December 2014 issue;Science-Business eXchange published a perspective on this work titled “MIDAS touch vaccine”;Annals of Translational Medicine published a perspective on this work titled “Blocking the ‘MIDAS’ touch of Enterococcus faecalis”;Highlighted by Science Daily, Medical Xpress, Counsel & Heal and Business Standard;Highlighted by Record, the Washington University News Letter;Highlighted by the National Public Radio and by the German Public Radio)

  12. Nielsen, H. V., Flores-Mireles, A. L., Kau A. L., Kline, K. A., Pinkner, J. S., Neiers, F., Normark, S., Henriques-Normark, B., Caparon, M. G., Hultgren, S. J. 2013. Pilin and sortase residues critical for endocarditis- and biofilm-associated pilus biogenesis in Enterococcus faecalis. J Bacteriol. 195(19):4484-95.

  13. Flores-Mireles, A. L., Eberhard, A. and Winans, S.C. 2012. Agrobacterium tumefaciens can obtain sulfur from an opine that is synthesized by octopine synthase using S-methylmethionine as a substrate. Mol. Microbiol. 84(5):845-56.

  14. Pinto, U. M., Flores-Mireles, A. L., Costa, E. D. and Winans, S. C. 2011. RepC protein of the octopine-type Ti plasmid binds to the probable origin of replication within repC and functions only in cis. Mol. Microbiol. 81 (6): 1593-606.

  15. Wei, Y., Ryan G. T., Flores-Mireles A. L., Costa E.D., Schneider D. J., and Winans S. C. 2011. Saturation mutagenesis of a CepR binding site as a means to identify new quorum-regulated promoters in Burkholderia cenocepacia. Mol Microbiol. 79 (3): 616-32.

  16. Holguin G., Vázquez P., Sánchez J., López de Los Santos Y., Flores-Mireles A. L., Melgarejo L. M., Vanegas J., Galindo T., Dávila A., Polanía J. and Ruiz, M. 2011. Microbiología del manglar In: Los manglares de la Península de Baja California. (Eds.) Serviere-Zaragoza, E., Félix-Pico, E.F., Riosmena-Rodriguez, R., León de la Luz, J.L. Published by: CIBNOR, La Paz, México.

  17. Flores-Mireles, A. L., S.C. Winans and G. Holguin. 2007. Molecular characterization of diazotrophic and denitrifying bacteria associated with mangrove roots. Appl. Environ. Microbiol. 73(22):7308-21.

  18. Flores-Mireles, A. L. and G. Holguin. 2003. Manglares: Importancia Económica vs. Ecológica. Análisis.  Volumen II. No. 29.  28-29. (Mexican Journal).

1 Protocol published
Authors:  Cristina Colomer-Winter, José A. Lemos and Ana L. Flores-Mireles, date: 03/20/2019, view: 4277, Q&A: 0
Biofilm formation is a well-known bacterial strategy that protects cells from hostile environments. During infection, bacteria found in a biofilm community are less sensitive to antibiotics and to the immune response, often allowing them to colonize ...
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