Melinda Fitzgerald Curtin University and the Perron Institute
1 protocol

Carole A Bartlett
  • 1 Author merit

Education

Master of Science, University of Manchester, U.K.

Current position

Research Assistant, Neuroscience, Curtin Health Innovation Research Institute, Sarich Neuroscience Research Institute, 8 Verdun St, Nedlands, 6009 WA, Australia, Australia

Publications (since 2000)

  1. Mao Y, Black AMB, Milbourn HR, Krakonja S, Nesbit M, Bartlett CA, Fehily B, Takechi R, Yates NJ, Fitzgerald M. The Effects of a Combination of Ion Channel Inhibitors in Female Rats Following Repeated Mild Traumatic Brain Injury. Int J Mol Sci. 2018 Oct 31;19(11). pii: E3408. doi: 10.3390/ijms19113408. PubMed PMID: 30384417.

  2. Toomey LM, Bartlett CA, Majimbi M, Gopalasingam G, Rodger J, Fitzgerald M. Comparison of ion channel inhibitor combinations for limiting secondary degeneration following partial optic nerve transection. Exp Brain Res. 2018 Oct 26. doi: 10.1007/s00221-018-5414-0. [Epub ahead of print] PubMed PMID: 30367192.

  3. Giacci MK, Bartlett CA, Smith NM, Iyer KS, Toomey LM, Jiang H, Guagliardo P, Kilburn MR, Fitzgerald M. Oligodendroglia Are Particularly Vulnerable to Oxidative Damage after Neurotrauma In Vivo. J Neurosci. 2018 Jul 18;38(29):6491-6504. doi: 10.1523/JNEUROSCI.1898-17.2018. Epub 2018 Jun 18. PubMed PMID: 29915135.

  4. Smith NM, Giacci MK, Gough A, Bailey C, McGonigle T, Black AMB, Clarke TO, Bartlett CA, Swaminathan Iyer K, Dunlop SA, Fitzgerald M. Inflammation and blood-brain barrier breach remote from the primary injury following neurotrauma. J Neuroinflammation. 2018 Jul 7;15(1):201. doi: 10.1186/s12974-018-1227-0. PubMed PMID: 29981582; PubMed Central PMCID: PMC6035802.

  5. Chiha W, LeVaillant CJ, Bartlett CA, Hewitt AW, Melton PE, Fitzgerald M, Harvey AR. Retinal genes are differentially expressed in areas of primary versus secondary degeneration following partial optic nerve injury. PLoS One. 2018 Feb 9;13(2):e0192348. doi: 10.1371/journal.pone.0192348. eCollection 2018. PubMed PMID: 29425209; PubMed Central PMCID: PMC5806857.

  6. O'Hare Doig RL, Chiha W, Giacci MK, Yates NJ, Bartlett CA, Smith NM, Hodgetts SI, Harvey AR, Fitzgerald M. Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma. BMC Neurosci. 2017 Aug 14;18(1):62. doi: 10.1186/s12868-017-0380-1. PubMed PMID: 28806920; PubMed Central PMCID: PMC5557315.

  7. Yates NJ, Lydiard S, Fehily B, Weir G, Chin A, Bartlett CA, Alderson J, Fitzgerald M. Repeated mild traumatic brain injury in female rats increases lipid peroxidation in neurons. Exp Brain Res. 2017 Jul;235(7):2133-2149. doi: 10.1007/s00221-017-4958-8. Epub 2017 Apr 17. PubMed PMID: 28417146.

  8. Yates NJ, Giacci MK, O'Hare Doig RL, Chiha W, Ashworth BE, Kenna J, Bartlett CA, Fitzgerald M. Delayed treatment of secondary degeneration following acute optic nerve transection using a combination of ion channel inhibitors. Neural Regen Res. 2017 Feb;12(2):307-316. doi: 10.4103/1673-5374.200814. PubMed PMID: 28400815; PubMed Central PMCID: PMC5361517.

  9. O'Hare Doig RL, Bartlett CA, Smith NM, Hodgetts SI, Dunlop SA, Hool L, Fitzgerald M. Specific combinations of ion channel inhibitors reduce excessive Ca2+ influx as a consequence of oxidative stress and increase neuronal and glial cell viability in vitro. Neuroscience. 2016 Dec 17;339:450-462. doi: 10.1016/j.neuroscience.2016.10.005. Epub 2016 Oct 8. PubMed PMID: 27725216.

  10. Lozić I, Hartz RV, Bartlett CA, Shaw JA, Archer M, Naidu PSR, Smith NM, Dunlop SA, Iyer KS, Kilburn MR, Fitzgerald M. Characterization of polymeric nanoparticles for treatment of partial injury to the central nervous system. Data Brief. 2016 Feb 16;7:152-156. doi: 10.1016/j.dib.2016.02.019. eCollection 2016 Jun. PubMed PMID: 28795116; PubMed Central PMCID: PMC5540673.

  11. Ashworth BE, Stephens E, Bartlett CA, Serghiou S, Giacci MK, Williams A, Hart NS, Fitzgerald M. Comparative assessment of phototherapy protocols for reduction of oxidative stress in partially transected spinal cord slices undergoing secondary degeneration. BMC Neurosci. 2016 May 18;17(1):21. doi: 10.1186/s12868-016-0259-6. PubMed PMID: 27194427; PubMed Central PMCID: PMC4872332.

  12. Smith NM, Gachulincova I, Ho D, Bailey C, Bartlett CA, Norret M, Murphy J, Buckley A, Rigby PJ, House MJ, St Pierre T, Fitzgerald M, Iyer KS, Dunlop SA. An Unexpected Transient Breakdown of the Blood Brain Barrier Triggers Passage of Large Intravenously Administered Nanoparticles. Sci Rep. 2016 Mar 4;6:22595. doi: 10.1038/srep22595. PubMed PMID: 26940762; PubMed Central PMCID: PMC4778073.

  13. Lozić I, Hartz RV, Bartlett CA, Shaw JA, Archer M, Naidu PS, Smith NM, Dunlop SA, Iyer KS, Kilburn MR, Fitzgerald M. Enabling dual cellular destinations of polymeric nanoparticles for treatment following partial injury to the central nervous system. Biomaterials. 2016 Jan;74:200-16. doi: 10.1016/j.biomaterials.2015.10.001. Epub 2015 Oct 9. PubMed PMID: 26461115.

  14. O'Hare Doig RL, Bartlett CA, Maghzal GJ, Lam M, Archer M, Stocker R, Fitzgerald M. Reactive species and oxidative stress in optic nerve vulnerable to secondary degeneration. Exp Neurol. 2014 Nov;261:136-46. doi: 10.1016/j.expneurol.2014.06.007. Epub 2014 Jun 12. PubMed PMID: 24931225.

  15. Giacci MK, Wheeler L, Lovett S, Dishington E, Majda B, Bartlett CA, Thornton E, Harford-Wright E, Leonard A, Vink R, Harvey AR, Provis J, Dunlop SA, Hart NS, Hodgetts S, Natoli R, Van Den Heuvel C, Fitzgerald M. Differential effects of 670 and 830 nm red near infrared irradiation therapy: a comparative study of optic nerve injury, retinal degeneration, traumatic brain and spinal cord injury. PLoS One. 2014 Aug 8;9(8):e104565. doi: 10.1371/journal.pone.0104565. eCollection 2014. PubMed PMID: 25105800; PubMed Central PMCID: PMC4126771.

  16. Lozić I, Bartlett CA, Shaw JA, Iyer KS, Dunlop SA, Kilburn MR, Fitzgerald M. Changes in subtypes of Ca microdomains following partial injury to the central nervous system. Metallomics. 2014 Mar;6(3):455-64. doi: 10.1039/c3mt00336a. Epub 2014 Jan 3. PubMed PMID: 24425149.

  17. Savigni DL, O'Hare Doig RL, Szymanski CR, Bartlett CA, Lozić I, Smith NM, Fitzgerald M. Three Ca2+ channel inhibitors in combination limit chronic secondary degeneration following neurotrauma. Neuropharmacology. 2013 Dec;75:380-90. doi: 10.1016/j.neuropharm.2013.07.034. Epub 2013 Aug 16. PubMed PMID: 23958451.

  18. Cummins N, Bartlett CA, Archer M, Bartlett E, Hemmi JM, Harvey AR, Dunlop SA, Fitzgerald M. Changes to mitochondrial ultrastructure in optic nerve vulnerable to secondary degeneration in vivo are limited by irradiation at 670 nm. BMC Neurosci. 2013 Sep 8;14:98. doi: 10.1186/1471-2202-14-98. PubMed PMID: 24011177; PubMed Central PMCID: PMC3844486.

  19. Szymanski CR, Chiha W, Morellini N, Cummins N, Bartlett CA, O'Hare Doig RL, Savigni DL, Payne SC, Harvey AR, Dunlop SA, Fitzgerald M. Paranode Abnormalities and Oxidative Stress in Optic Nerve Vulnerable to Secondary Degeneration: Modulation by 670 nm Light Treatment. PLoS One. 2013 Jun 19;8(6):e66448. doi: 10.1371/journal.pone.0066448. Print 2013. PubMed PMID: 23840470; PubMed Central PMCID: PMC3686728.

  20. Payne SC, Bartlett CA, Savigni DL, Harvey AR, Dunlop SA, Fitzgerald M. Early proliferation does not prevent the loss of oligodendrocyte progenitor cells during the chronic phase of secondary degeneration in a CNS white matter tract. PLoS One. 2013 Jun 11;8(6):e65710. doi: 10.1371/journal.pone.0065710. Print 2013. PubMed PMID: 23776532; PubMed Central PMCID: PMC3679191.

  21. Payne SC, Bartlett CA, Harvey AR, Dunlop SA, Fitzgerald M. Myelin sheath decompaction, axon swelling, and functional loss during chronic secondary degeneration in rat optic nerve. Invest Ophthalmol Vis Sci. 2012 Sep 4;53(10):6093-101. doi: 10.1167/iovs.12-10080. PubMed PMID: 22879411.

  22. Harrison J, Bartlett CA, Cowin G, Nicholls PK, Evans CW, Clemons TD, Zdyrko B, Luzinov IA, Harvey AR, Iyer KS, Dunlop SA, Fitzgerald M. In vivo imaging and biodistribution of multimodal polymeric nanoparticles delivered to the optic nerve. Small. 2012 May 21;8(10):1579-89. doi: 10.1002/smll.201102648. Epub 2012 Mar 13. PubMed PMID: 22411702.

  23. Wells J, Kilburn MR, Shaw JA, Bartlett CA, Harvey AR, Dunlop SA, Fitzgerald M. Early in vivo changes in calcium ions,oxidative stress markers, and ion channel immunoreactivity following partial injury to the optic nerve. J Neurosci Res. 2012 Mar;90(3):606-18. doi: 10.1002/jnr.22784. Epub 2011 Oct 31. PubMed PMID: 22038561.

  24. Payne SC, Bartlett CA, Harvey AR, Dunlop SA, Fitzgerald M. Chronic swelling and abnormal myelination during secondary degeneration after partial injury to a central nervous system tract. J Neurotrauma. 2011 Jun;28(6):1077-88. doi: 10.1089/neu.2010.1665. Epub 2011 May 5. PubMed PMID: 21381867.

  25. Ho D, Fitzgerald M, Bartlett CA, Zdyrko B, Luzinov IA, Dunlop SA, Swaminathan Iyer K. The effects of concentration-dependent morphology of self-assembling RADA16 nanoscaffolds on mixed retinal cultures. Nanoscale. 2011 Mar;3(3):907-10. doi: 10.1039/c0nr00666a. Epub 2010 Dec 3. PubMed PMID: 21132164.

  26. Fitzgerald M, Bartlett CA, Payne SC, Hart NS, Rodger J, Harvey AR, Dunlop SA. Near infrared light reduces oxidative stress and preserves function in CNS tissue vulnerable to secondary degeneration following partial transection of the optic nerve. J Neurotrauma. 2010 Nov;27(11):2107-19. doi: 10.1089/neu.2010.1426. PubMed PMID: 20822460.

  27. Selt M, Bartlett CA, Harvey AR, Dunlop SA, Fitzgerald M. Limited restoration of visual function after partial optic nerve injury; a time course study using the calcium channel blocker lomerizine. Brain Res Bull. 2010 Mar 16;81(4-5):467-71. doi: 10.1016/j.brainresbull.2009.11.004. Epub 2009 Nov 11. PubMed PMID: 19913075.

  28. Fitzgerald M, Bartlett CA, Harvey AR, Dunlop SA. Early events of secondary degeneration after partial optic nerve transection: an immunohistochemical study. J Neurotrauma. 2010 Feb;27(2):439-52. doi: 10.1089/neu.2009.1112. PubMed PMID: 19852581.

  29. Fitzgerald M, Payne SC, Bartlett CA, Evill L, Harvey AR, Dunlop SA. Secondary retinal ganglion cell death and the neuroprotective effects of the calcium channel blocker lomerizine. Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5456-62. doi: 10.1167/iovs.09-3717. Epub 2009 May 27. PubMed PMID: 19474405.

  30. Fitzgerald M, Bartlett CA, Evill L, Rodger J, Harvey AR, Dunlop SA. Secondary degeneration of the optic nerve following partial transection: the benefits of lomerizine. Exp Neurol. 2009 Mar;216(1):219-30. doi: 10.1016/j.expneurol.2008.11.026. Epub 2008 Dec 11. PubMed PMID: 19118550.

  31. Haustead DJ, Lukehurst SS, Clutton GT, Bartlett CA, Dunlop SA, Arrese CA, Sherrard RM, Rodger J. Functional topography and integration of the contralateral and ipsilateral retinocollicular projections of ephrin-A-/- mice. J Neurosci. 2008 Jul 16;28(29):7376-86. doi: 10.1523/JNEUROSCI.1135-08.2008. PubMed PMID: 18632942.

  32. Fitzgerald M, Nairn P, Bartlett CA, Chung RS, West AK, Beazley LD. Metallothionein-IIA promotes neurite growth via the megalin receptor. Exp Brain Res. 2007 Nov;183(2):171-80. Epub 2007 Jul 19. PubMed PMID: 17634932.

  33. Symonds AC, King CE, Bartlett CA, Sauvé Y, Lund RD, Beazley LD, Dunlop SA, Rodger J. EphA5 and ephrin-A2 expression during optic nerve regeneration: a 'two-edged sword'. Eur J Neurosci. 2007 Feb;25(3):744-52. PubMed PMID: 17328773.

  34. Beazley LD, Rodger J, King CE, Bartlett CA, Taylor AL, Dunlop SA. Optic nerve regeneration: molecular pre-requisites and the role of training. Restoring vision after optic nerve injury. Adv Exp Med Biol. 2006;572:389-95. Review. PubMed PMID: 17249601.

  35. Rodger J, Symonds AC, Springbett J, Shen WY, Bartlett CA, Rakoczy PE, Beazley LD, Dunlop SA. Eph/ephrin expression in the adult rat visual system following localized retinal lesions: localized and transneuronal up-regulation in the retina and superior colliculus. Eur J Neurosci. 2005 Oct;22(8):1840-52. PubMed PMID: 16262624.

  36. Rodger J, Vitale PN, Tee LB, King CE, Bartlett CA, Fall A, Brennan C, O'Shea JE, Dunlop SA, Beazley LD. EphA/ephrin-A interactions during optic nerve regeneration: restoration of topography and regulation of ephrin-A2 expression. Mol Cell Neurosci. 2004 Jan;25(1):56-68. PubMed PMID: 14962740.

  37. Rodger J, Bartlett CA, Harman AM, Thomas C, Beazley LD, Dunlop SA. Evidence that regenerating optic axons maintain long-term growth in the lizard Ctenophorus ornatus: growth-associated protein-43 and gefiltin expression. Neuroscience. 2001;102(3):647-54. PubMed PMID: 11226701.

  38. Rodger J, Bartlett CA, Beazley LD, Dunlop SA. Transient up-regulation of the rostrocaudal gradient of ephrin A2 in the tectum coincides with reestablishment of orderly projections during optic nerve regeneration in goldfish. Exp Neurol. 2000 Nov;166(1):196-200. PubMed PMID: 11031096.

  39. Nona SN, Thomlinson AM, Bartlett CA, Scholes J. Schwann cells in the regenerating fish optic nerve: evidence that CNS axons, not the glia, determine when myelin formation begins. J Neurocytol. 2000 Apr;29(4):285-300. PubMed PMID: 11276180.

1 Protocol published
Partial Transection of Adult Rat Optic Nerve as a Model of Secondary Degeneration in the Central Nervous System
Authors:  Carole A Bartlett and Melinda Fitzgerald, date: 12/20/2018, view: 237, Q&A: 0
Injury to the central nervous system is characterized by damage that spreads from the initial point of impact into the surrounding adjacent tissue, in a phenomenon referred to as secondary degeneration. The optic nerve can be used to effectively ...
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