Pierre-Louis Tharaux Institut National de la Santé et de la Recherche Médicale
1 protocol

Olivia Lenoir INSERM
1 protocol

Carole Henique
  • Associate Professor, Institut Mondor de Recherche Biomédicale , Inserm U955/University Paris Est Créteil, France
Research focus
  • Cell biology
  • 1 Author merit


PhD in phathophysiology, University Pierre et Marie Curie, Paris, France, 2010


  1. Leibler C, Thiolat A*, Henique C*, Samson C, Pilon C, Tamagne M, Noizat-Pirenne F, Vingert B, Cohen JL, Grimbert P. Control of humoral response in renal transplantation by CTLA4-Ig depends on a direct effect on B cells and impaired T follicular helper (Tfh)- B cells crosstalk. J Am Soc Nephrol. 2018 Mar;29(3):1049-1062 
  2. Henique C, Bollée G, Loyer X, Grahammer F, Dhaun N, Camus M, Vernerey J, Guyonnet L, Gaillard F, Lazareth H, Meyer C, Bensaada I, Legrès L, Satoh T, Akira S, Bruneval P, Dimmeler S, Tedgui A, Karras A, Thervet E, Nochy D, Huber TB, Mesnard L, Lenoir O, Tharaux PL. Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis. Nat Commun. 2017 Nov 28;8(1):1829 
  3. Boumediene A, Vachin P, Sendeyo K, Oniszczuk J, Zhang SY, Henique C, Pawlak A, Audard V, Ollero M, Guigonis V, Sahali D. NEPHRUTIX: a randomized, double-blind, placebo vs Rituximab-controlled trial assessing T-cell subset changes in Minimal Change Nephrotic Syndrome. J Autoimmun. 2018 Mar;88:91-102 
  4. Sonneveld R, Hoenderop JG, Isidori AM, Henique C, Dijkman HB, Berden JH, Tharaux PL, van der Vlag J, Nijenhuis T. Sildenafil prevents podocyte injury via PPAR-γ mediated TRPC6 inhibition. J Am Soc Nephrol. 2017 May;28(5):1491-1505. 
  5. Joffre J, Potteaux S, Zeboudj L, Loyer X, Boufenzer A, Laurans L, Esposito B, Vandestienne M, de Jager SC, Henique C, Zlatanova I, Taleb S, Bruneval P, Tedgui A, Mallat Z, Gibot S, Ait-Oufella H. Genetic and Pharmacological Inhibition of TREM-1 Limits the Development of Experimental Atherosclerosis. J Am Coll Cardiol. 2016 Dec 27;68(25):2776-2793 
  6. Capel F, Cheraiti N, Acquaviva C, Henique C, B Bertrand-Michel J, Vianey-Saban C, Prip-Buus C, Morio B. Oleate dose-dependently regulates palmitate metabolism and insulin signaling in C2C12 myotubes. Biochim Biophys Acta. 2016 Oct 8;1861(12 Pt A):2000-2010. 
  7. Moktefi A, Zhang SY, Vachin P, Ory V, Henique C, Audard V, Rucker-Martin C, Gouadon E, Eccles M, Schedl A, Heidet L, Ollero M, Sahali D, Pawlak A. Repression of CMIP transcription by WT1 is relevant to podocyte health. Kidney Int. 2016 Dec;90(6):1298-1311. 
  8. Loyer X, Paradis V, Henique C, Vion AC, Colnot N, Guerin CL, Devue C, Scetbun J, Romain M, Paul JP, Rothenberg ME, Marcellin P, Durand F, Bedossa P, Boulanger CM, Tedgui A, Rautou PE. MicroRNA-21 contributes to Non Alcoholic Steatohepatitis: Experimental and Clinical Evidences. Gut. 2016 Nov;65(11):1882-1894. 
  9. Lenoir O, Jasiek M, Henique C, Guyonnet L, Hartleben B, Bork T, Chipont A, Flosseau K, Bensaada I, Schmitt A, Massé JM, Souyri M, Huber TB, Tharaux PL. Endothelial cell- and Podocyte Autophagy Synergistically protect from Diabetes-induced Glomerulosclerosis. Autophagy. 2015;11(7):1130-45. 
  10. Henique C, Bollee G, Lenoir O, Dhaun N, Camus M, Chipont A, Flosseau K, Mandet C, Yamamoto M, Karras A, , Thervet E, Bruneval P, Nochy D, Mesnard L, Tharaux PL. NRF2 Drives Podocyte-Specific PPARg Expression that Is Essential to Promotes Resistance to Crescentic Glomerulonephritis. Proof of Principle for Potential Therapy. J Am Soc Nephrol. 2016 Jan;27(1):172-88. 
  11. Henique C, Mansouri A, Lenoir V, Esnous C, Ferry A, Ramond E, Girard J, Prip-Buus C, Cohen I. Increasing Muscle Fatty Acid Oxidation Induces Skeletal Muscle towards an oxidative phenotype. FASEB J. 2015 Jun;29(6):2473-83. 
  12. Henique C, Papista C, Guyonnet L, Lenoir O, Tharaux PL. Update on crescentic glomerulonephritis. Semin Immunopathol. 2014 Jul;36(4):479-90. 
  13. Lenoir O, Milon M, Virsolvy A, Henique C, Schmitt A, Masse JM, Kotelevtsev Y, YanagisawaM, Webb DJ, Richard S and Tharaux PL. Direct action of endothelin-1 on podocytes promotes diabetic glomerulosclerosis. J Am Soc Nephrol, 2014, May;25(5):1050-62. 
  14. Henique C, Fligny C, Tharaux PL. Crescent formation: unraveling local mediators that break glomerular epithelial cell tolerance to immune injury. Press Med, 2013. 16th International Vasculitis and ANCA Workshop, Paris, France. 
  15. Henique C, Tharaux PL. Targeting signaling pathways in glomerular diseases. Curr Opin Nephrol Hypertens, 2012 Jul;21(4):417-27. 
  16. Flamant M, Bollee G, Henique C, Tharaux PL. Epidermal growth factor: a new therapeutic target in glomerular disease. Nephrol Dial Transplant, 2012 Apr;27(4):1297-304. 
  17. Henique C, Mansouri A, Fumey G, Lenoir V, Girard J, Bouillaud F, Prip-Buus C, Cohen I. Increased mitochondrial fatty acid oxidation is sufficient to protect muscle cells against palmitate-induced apoptosis. J Biol Chem. 2010 Nov 19;285(47):36818-27. 
  18. Perilhou A, Tourrel-Cuzin C, Kharroubi I, Henique C, Fauveau V, Kitamura T, Magnan C, Postic C, Prip-Buus C, Vasseur-Cognet M. The transcription factor COUP-TFII is negatively regulated by insulin and glucose via Foxo1- and ChREBP-controlled pathways. Mol Cell Biol. 2008 Nov;28(21):6568-79.
1 Protocol published
Immunofluorescence Staining of WT-1/Podocalyxin on Mouse Kidney Sections
Authors:  Carole Henique, Olivia Lenoir and Pierre-Louis Tharaux, date: 04/20/2019, view: 3755, Q&A: 0
In glomerular diseases, podocytes are one type of cells involved in dysfunction of glomerular filtration. In these conditions, podocyte proteins expression change. Therefore, immunofluorescent staining of podocytes can be performed to visualize ...
We use cookies on this site to enhance your user experience. By using our website, you are agreeing to allow the storage of cookies on your computer.