Stephan Urban Department of Infectious Diseases, Molecular Virology, University Hospital Heidelberg, Germany, Germany,
1 protocol

Bingqian Qu
  • Graduate, Department of Infectious Diseases, Molecular Virology, University Hospital Heidelberg, Germany
Research focus
  • My research interests include virological aspects of two RNA viruses (Orthomyxovirus and Bunyavirus) and a DNA virus (Hepadnavirus).
  • 1 Author merit

Education

M.Sc., Nanjing University, 2011

Lab information

Stephan Urban lab
https://www.klinikum.uni-heidelberg.de/AG-Urban.104952.0.html

Publications

  1. https://scholar.google.com/citations?user=-_gN8jQAAAAJ&hl=en 
  2. https://www.researchgate.net/profile/Bingqian_Qu
  3. Qu B, Ni Y, Lempp FA, Vondran FWR, Urban S. T5 Exonuclease Hydrolysis of Hepatitis B Virus Replicative Intermediates Allows Reliable Quantification and Fast Drug Efficacy Testing of Covalently Closed Circular DNA by PCR. J Virol. 2018; 92(23). doi: 10.1128/JVI.01117-18.
  4. Mutz P, Metz P, Lempp FA, Bender S, Qu B, Schöneweis K, Seitz S, Tu T, Restuccia A, Frankish J, Dächert C, Schusser B, Koschny R, Polychronidis G, Schemmer P, Hoffmann K, Baumert TF, Binder M, Urban S, Bartenschlager R. HBV bypasses the innate immune response and does not protect HCV from antiviral activity of interferon. Gastroenterology. 2018; 154(6): 1791-1804.e22.
  5. Li X*, Qu B*, He G, Cardona CJ, Song Y, Xing Z. Critical role of HAX-1 in promoting avian influenza virus replication in lung epithelial cells. Mediators Inflamm. 2018: 3586132 doi.org/10.1155/2018/3586132.
    *: Equally contributed
  6. Lempp FA, Wiedtke E, Qu B, Roques P, Chemin I, Vondran FW, Le Grand R, Grimm D, Urban S. Sodium taurocholate cotransporting polypeptide is the limiting host factor of Hepatitis B Virus infection in macaque and pig hepatocytes. Hepatology. 2017; 66(3): 703-716.
  7. Sommer AF, Rivière L, Qu B, Schott K, Riess M, Ni Y, Shepard C, Schnellbächer E, Finkernagel M, Himmelsbach K, Welzel K, Kettern N, Donnerhak C, Münk C, Flory E, Liese J, Kim B, Urban S, König R. Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle. Sci Rep. 2016; 6: 26616.
  8. Lempp FA, Qu B, Wang YX, Urban S. Hepatitis B Virus infection of a mouse hepatic cell line reconstituted with human sodium taurocholate cotransporting polypeptide. J Virol. 2016; 90(9): 4827-4831.
  9. Wu X, Qi X, Qu B, Zhang Z, Liang M, Li C, Cardona CJ, Li D, Xing Z. Evasion of antiviral immunity through sequestering of TBK1/IKK/IRF3 into viral inclusion bodies. J Virol. 2014; 88(6): 3067-3076.
  10. Qu B*, Qi X*, Wu X, Liang M, Li C, Cardona CJ, Xu W, Tang F, Li Z, Wu B, Powell K, Wegner M, Li D, Xing Z. Suppression of the interferon and NF-kB responses by severe fever with thrombocytopenia syndrome virus. J Virol. 2012; 86(16): 8388-8401. *: Equally contributed
  11. Gao W, Sun W, Qu B, Cardona CJ, Powell K, Wegner M, Shi Y, Xing Z. Distinct regulation of host responses by ERK and JNK MAP kinases in swine macrophages infected with pandemic (H1N1) 2009 influenza virus. PLoS One. 2012; 7(1): e30328.
  12. Qu B, Li X, Gao W, Sun W, Jin Y, Cardona CJ, Xing Z. Human intestinal epithelial cells are susceptible to influenza virus subtype H9N2. Virus Res. 2012; 163(1): 151-159.
  13. Zhao W, Zhang T, Qu B, Wu X, Zhu X, Meng F, Gu Y, Shu Y, Shen Y, Sun Y, Xu Q. Sorafenib induces apoptosis in HL60 cells by inhibiting Src kinase-mediated STAT3 phosphorylation. Anticancer Drugs. 2011; 22(1): 79-88.
  14. Xing Z, Harper R, Anunciacion J, Yang Z, Gao W, Qu B, Guan Y, Cardona CJ. Host immune and apoptotic responses to avian influenza virus H9N2 in human tracheobronchial epithelial cells. Am J Respir Cell Mol Biol. 2011; 44(1): 24-33.
  15. Gu Y, Zhao W, Meng F, Qu B, Zhu X, Sun Y, Shu Y, Xu Q. Sunitinib impairs the proliferation and function of human peripheral T cell and prevents T-cell-mediated immune response in mice. Clin Immunol. 2010; 135(1): 55-62.
  16. Zhao W, Gu YH, Song R, Qu BQ, Xu Q. Sorafenib inhibits activation of human peripheral blood T cells by targeting LCK phosphorylation. Leukemia. 2008; 22(6): 1226-1233.
1 Protocol published
Quantification of Hepatitis B Virus Covalently Closed Circular DNA in Infected Cell Culture Models by Quantitative PCR
Authors:  Bingqian Qu and Stephan Urban, date: 04/05/2019, view: 1539, Q&A: 0
Persistence of the human hepatitis B virus (HBV) requires the maintenance of covalently closed circular (ccc)DNA, the episomal genome reservoir in nuclei of infected hepatocytes. cccDNA elimination is a major aim in future curative therapies ...
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